Reactome | CPSF4 [nucleoplasm]

CPSF4 [nucleoplasm]

Stable Identifier

R-HSA-169104

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CPSF30, Cleavage and polyadenylation specificity factor subunit 4, Cleavage and polyadenylation specificity factor 30 kDa subunit, NEB1, NAR

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF4 [nucleoplasm] (Homo sapiens)
      - upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF4 [nucleoplasm] (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF4 [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95639 CPSF4

Gene Names

CPSF4, CPSF30, NAR, NEB1

Chain

chain:1-269

Reference Genes

BioGPS Gene:10898 CPSF4

COSMIC (genes):CPSF4 CPSF4

CTD Gene:10898 CPSF4

dbSNP Gene:10898 CPSF4

ENSEMBL:ENSG00000160917 CPSF4

HGNC:2327 CPSF4

KEGG:hsa:10898 CPSF4

Monarch:10898 CPSF4

NCBI Gene:10898 CPSF4

OMIM:603052 CPSF4

UCSC:O95639 CPSF4

Reference Transcript

Other Identifiers

10898

11734082_a_at

11739169_a_at

11747753_a_at

17048923

206688_PM_s_at

206688_s_at

3014765

3014766

3014767

3014770

3014771

3014773

3014774

3014776

3014777

3014778

3014779

3014780

3014781

3014782

3014783

3014784

3014785

3014786

3014787

3014788

3014789

3014790

3014793

3014794

3014795

3014796

3014797

3014798

35743_at

8134599

A_14_P100742

A_23_P42997

GE59454

GO:0003676

GO:0003677

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005847

GO:0006397

GO:0008270

GO:0016071

GO:0031124

GO:0043226

GO:0043231

GO:0046872

GO:1990837

HMNXSV003004124

ILMN_1660426

ILMN_2357260

PH_hs_0025371

TC07000594.hg

g5729938_3p_a_at

Participates

as a component of

as an input of

Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF) (Homo sapiens)

Inferred To

Clp [nucleoplasm] (Drosophila melanogaster)

YTH1 [nucleoplasm] (Saccharomyces cerevisiae)

Cpsf4 [nucleoplasm] (Mus musculus)

Cpsf4 [nucleoplasm] (Rattus norvegicus)

cpsf-4 [nucleoplasm] (Caenorhabditis elegans)

CPSF4 [nucleoplasm] (Bos taurus)

CPSF4 [nucleoplasm] (Canis familiaris)

CPSF4 [nucleoplasm] (Gallus gallus)

CPSF4 [nucleoplasm] (Sus scrofa)

cpsf4 [nucleoplasm] (Danio rerio)

cpsf4 [nucleoplasm] (Dictyostelium discoideum)

cpsf4 [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of CPSF4 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001305089.1, NP_006684.1, NP_001305090.1, NP_001305091.1, NP_001075028.1

OpenTargets

ENSG00000160917

ENSEMBL

ENST00000292476, ENST00000436336, ENSP00000395311, ENSP00000292476

HPA

ENSG00000160917-CPSF4

PRO

O95639

Pharos - Targets

O95639

GlyGen

O95639

PDB

6URO, 8E3Q, 6URG, 6DNH, 2D9N, 8E3I, 6FUW, 7ZYH, 7K95, 8R8R, 2RHK

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6UN15 FIP1L1	9	FIP1L1 [nucleoplasm] (R-HSA-6805150) FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9672499) FIP1L1(1-272)-PDGFRA(567-1089) fusion [cytosol] (R-HSA-9672496) FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol] (R-HSA-9672502) FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol] (R-HSA-9672506) p-11Y-FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673872) p-11Y-FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol] (R-HSA-9673621) p-11Y-FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol] (R-HSA-9673879) p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol] (R-HSA-9673867)	0.659	5
UniProt:Q9UKF6 CPSF3	1	CPSF3 [nucleoplasm] (R-HSA-71993)	0.643	4
UniProt:Q10570 CPSF1	1	CPSF1 [nucleoplasm] (R-HSA-71989)	0.564	2
UniProt:P50222 MEOX2			0.556	3
IntAct:EBI-10185891 81608			0.556	3
UniProt:Q9C0J8 WDR33	1	WDR33 [nucleoplasm] (R-HSA-8938784)	0.527	5
UniProt:Q92797 SYMPK	1	SYMPK [nucleoplasm] (R-HSA-4615988)	0.527	3
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.499	3
UniProt:I6T1Z2 I6T1Z2			0.499	5
UniProt:Q194T2 Q194T2			0.499	5
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	2
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.483	2
UniProt:Q16630 CPSF6	2	CPSF6(1-490)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614368) CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838987)	0.483	2