IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol

Stable Identifier
R-HSA-169683
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Release of calcium from intracellular stores by IP3 receptor activation
ReviewStatus
5/5
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IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol
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IP3 promotes the release of intracellular calcium.
Participants
Input
Output
Participates
as an event of
Catalyst Activity

monoatomic cation channel activity of ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]

Physical Entity
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monoatomic cation channel activity (GO:0005261)
This event is regulated
Negatively by
Regulator
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
Active Unit
AHCYL1:NAD+ [endoplasmic reticulum membrane]
Positively by
Regulator
I(1,4,5)P3 [cytosol]
Inferred From
Calcium release from intracellular stores by IP3 receptor activation (Rattus norvegicus)
Cross References
Rhea
Authored
Jassal, B  (2004-03-31)
Le Novere, N  (2004-03-31)
Reviewed
Gillespie, ME  (2009-06-02)
Created
Jassal, B  (2005-11-30)
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