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ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-169696
Type
Complex
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
FCGR3A-mediated IL10 synthesis (Homo sapiens)
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
STIM1 oligomerizes (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Role of phospholipids in phagocytosis (Homo sapiens)
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Homo sapiens)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated cell proliferation (Homo sapiens)
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
Participants
components
x 4
I(1,4,5)P3 [cytosol]
ITPR tetramers [endoplasmic reticulum membrane]
(Homo sapiens)
Participates
as an input of
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Homo sapiens)
as an output of
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
as a component of
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
(Bos taurus)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
(Canis familiaris)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
(Drosophila melanogaster)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
(Gallus gallus)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
(Mus musculus)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
(Rattus norvegicus)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
(Sus scrofa)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
(Xenopus tropicalis)
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