Regulation of Apoptosis

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R-HSA-169911
Type
Pathway
Species
Homo sapiens
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A regulated balance between cell survival and apoptosis is essential for normal development and homeostasis of multicellular organisms (see Matsuzawa, 2001). Defects in control of this balance may contribute to autoimmune disease, neurodegeneration and cancer. Protein ubiquitination and degradation is one of the major mechanisms that regulate apoptotic cell death (reviewed in Yang and Yu 2003).

Literature References
PubMed ID Title Journal Year
11432772 Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1

Matsuzawa, A, Ichijo, H

J Biochem 2001
12724336 Regulation of apoptosis: the ubiquitous way

Yang, Y, Yu, X

FASEB J 2003
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