Reactome | Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus

Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus

Stable Identifier

R-HSA-170044

Type

Reaction

Species

Homo sapiens

Compartment

nuclear envelope

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Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus

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During interphase, cyclin B1:Cdc2 shuttles continuously in and out of the nucleus. Cyclin B1:Cdc2 is transported into the nucleus by an unusual mechanism that requires importin b but not importin a or Ran. Dissociation of the cyclin-B1:Cdc2:importin complex in the nucleus requires ATP and involves other yet unidentified nuclear factors (Takizawa et al.,1991).

Literature References

PubMed ID	Title	Journal	Year
10393926	Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta Takizawa, CG, Weis, K, Morgan, DO	Proc Natl Acad Sci U S A	1999
9670027	MPF localization is controlled by nuclear export Hagting, A, Karlsson, C, Clute, P, Jackman, M, Pines, J	EMBO J	1998
9679058	Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1 Yang, J, Bardes, ES, Moore, JD, Brennan, J, Powers, MA, Kornbluth, S	Genes Dev	1998