Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus

Stable Identifier
R-HSA-170044
Type
Reaction
Species
Homo sapiens
Compartment
nuclear envelope
Locations in the PathwayBrowser
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Summation

During interphase, cyclin B1:Cdc2 shuttles continuously in and out of the nucleus. Cyclin B1:Cdc2 is transported into the nucleus by an unusual mechanism that requires importin b but not importin a or Ran. Dissociation of the cyclin-B1:Cdc2:importin complex in the nucleus requires ATP and involves other yet unidentified nuclear factors (Takizawa et al.,1991).

Literature References
PubMed ID Title Journal Year
10393926 Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta

Takizawa, CG, Weis, K, Morgan, DO

Proc Natl Acad Sci U S A 1999
9670027 MPF localization is controlled by nuclear export

Hagting, A, Karlsson, C, Clute, P, Jackman, M, Pines, J

EMBO J 1998
9679058 Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1

Yang, J, Bardes, ES, Moore, JD, Brennan, J, Powers, MA, Kornbluth, S

Genes Dev 1998
Participants
Input
Output
Participant Of
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Orthologous Events
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Bos taurus)
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Canis familiaris)
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Danio rerio)
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Drosophila melanogaster)
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Mus musculus)
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Rattus norvegicus)
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Saccharomyces cerevisiae)
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Schizosaccharomyces pombe)
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Sus scrofa)
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Xenopus tropicalis)