Reactome: A Curated Pathway Database

Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus

Stable Identifier
R-HSA-170044
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

During interphase, cyclin B1:Cdc2 shuttles continuously in and out of the nucleus. Cyclin B1:Cdc2 is transported into the nucleus by an unusual mechanism that requires importin b but not importin a or Ran. Dissociation of the cyclin-B1:Cdc2:importin complex in the nucleus requires ATP and involves other yet unidentified nuclear factors (Takizawa et al.,1991).

Literature References
Participants
Participant Of
Orthologous Events