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p-4S-CCNB1 [cytosol]
Stable Identifier
R-HSA-170058
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S126,S128,S133,S144-CCNB1, phospho-Cyclin B1 (CRS)
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Cyclin A/B1/B2 associated events during G2/M transition (Homo sapiens)
Phosphorylation of Cyclin B1 in the CRS domain (Homo sapiens)
Phospho-Cyclin B1 (CRS):phospho-Cdc2(Thr 161) [cytosol] (Homo sapiens)
p-4S-CCNB1 [cytosol] (Homo sapiens)
Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Homo sapiens)
phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) [cytosol] (Homo sapiens)
p-4S-CCNB1 [cytosol] (Homo sapiens)
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Homo sapiens)
cytoplasmic Cyclin B1:Cdc2 complexes [cytosol] (Homo sapiens)
phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) [cytosol] (Homo sapiens)
p-4S-CCNB1 [cytosol] (Homo sapiens)
General
At the onset of mitosis, Cyclin B1 is phosphorylated in the CRS region. The identity of the kinase(s) responsible for this phosphorylation have not yet been determined with certainty.
External Reference Information
External Reference
UniProt:P14635 CCNB1
Gene Names
CCNB1, CCNB
Chain
chain:1-433
Reference Genes
BioGPS Gene:891 CCNB1
COSMIC (genes):CCNB1 CCNB1
CTD Gene:891 CCNB1
dbSNP Gene:891 CCNB1
ENSEMBL:ENSG00000134057 CCNB1
ENSEMBL_homo_sapiens_GENE:ENSG00000134057.15 CCNB1
HGNC:1579 CCNB1
KEGG Gene (Homo sapiens):891 CCNB1
Monarch:891 CCNB1
NCBI Gene:891 CCNB1
OMIM:123836 CCNB1
UCSC:P14635 CCNB1
Reference Transcript
RefSeq:NM_031966.3 CCNB1
Other Identifiers
11723939_a_at
16985599
1945_at
214710_PM_s_at
214710_s_at
228729_PM_at
228729_at
2813416
2813417
2813418
2813419
2813421
2813422
2813423
2813424
2813425
2813427
2813429
2813432
2813434
2813435
2813436
2813437
34736_at
63638_at
8105828
891
A_33_P3401621
GE57886
GO:0000086
GO:0000278
GO:0000922
GO:0000940
GO:0001701
GO:0005113
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005759
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006091
GO:0007010
GO:0007049
GO:0007052
GO:0007059
GO:0007080
GO:0010971
GO:0016020
GO:0016538
GO:0019901
GO:0023052
GO:0043226
GO:0044389
GO:0044772
GO:0045787
GO:0045931
GO:0048146
GO:0048856
GO:0051301
GO:0051987
GO:0061575
GO:0090266
GO:0097125
GO:0098772
GO:0140014
GO:1905448
HMNXSV003039343
Hs.23960.0.S1_3p_at
Hs.23960.2.S1_3p_a_at
ILMN_1712803
M25753_at
PH_hs_0002110
TC05000298.hg
TC05002418.hg
Participates
as a component of
Phospho-Cyclin B1 (CRS):phospho-Cdc2(Thr 161) [cytosol] (Homo sapiens)
phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) [cytosol] (Homo sapiens)
Other forms of this molecule
CCNB1 [nucleoplasm]
p-4S-CCNB1 [nucleoplasm]
CCNB1 [cytosol]
Inferred To
phospho-CycB [cytosol]
(Drosophila melanogaster)
phospho-cyb-2.1 [cytosol]
(Caenorhabditis elegans)
phospho-ccnb1 [cytosol]
(Danio rerio)
phospho-cyb-2.2 [cytosol]
(Caenorhabditis elegans)
Homologues of p-4S-CCNB1 [cytosol]
(Caenorhabditis elegans)
phospho-Ccnb1 [cytosol]
(Mus musculus)
phospho-Ccnb1 [cytosol]
(Rattus norvegicus)
phospho-CCNB1 [cytosol]
(Bos taurus)
phospho-CCNB1 [cytosol]
(Canis familiaris)
phospho-CCNB1 [cytosol]
(Sus scrofa)
phospho-cyb-1 [cytosol]
(Caenorhabditis elegans)
phospho-ccnb1.2 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 126
Coordinate
126
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 128
Coordinate
128
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 133
Coordinate
133
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 147
Coordinate
147
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_114172.1
OpenTargets
ENSG00000134057
ZINC - Substances
CCNB1_HUMAN
GeneCards
P14635
HPA
ENSG00000134057-CCNB1
Ensembl
ENST00000505500
,
ENSG00000134057
,
ENSP00000424588
,
ENSP00000256442
,
ENST00000256442
ZINC target
P14635
PRO
P14635
Pharos - Targets
P14635
ZINC - Predictions - Purchasable
CCNB1_HUMAN
PDB
5HQ0
,
4Y72
,
8TAU
,
5LQF
,
2JGZ
,
6GU3
,
7NJ0
,
6GU4
,
6GU2
,
8TAR
,
4YC3
,
2B9R
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06493 CDK1
11
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [cytosol]
(R-HSA-170075)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
0.976
28
UniProt:Q00535 CDK5
4
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
0.886
8
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.877
11
UniProt:Q99640 PKMYT1
3
PKMYT1 [cytosol]
(R-HSA-157457)
p-PKMYT1 [nucleoplasm]
(R-HSA-162650)
PKMYT1 [nucleoplasm]
(R-HSA-74386)
0.867
8
UniProt:P46527 CDKN1B
8
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
CDKN1B [cytosol]
(R-HSA-198622)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
0.744
6
UniProt:P38936 CDKN1A
5
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
CDKN1A [cytosol]
(R-HSA-182512)
CDKN1A [nucleoplasm]
(R-HSA-182585)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
0.731
5
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.643
4
UniProt:P33552 CKS2
0.643
4
UniProt:P11440 Cdk1
11
phospho-p-T161-CDK1 [nucleoplasm]
(R-MMU-170066)
phospho-p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-MMU-170074)
phospho-p-T161-CDK1 [cytosol]
(R-MMU-157415)
phospho-p-T14,Y15,T161-CDK1 [cytosol]
(R-MMU-170071)
CDK1 [cytosol]
(R-MMU-170075)
phospho-p-T14-CDK1 [cytosol]
(R-MMU-170064)
phospho-p-T14-CDK1 [nucleoplasm]
(R-MMU-170045)
Cdk1 [nucleoplasm]
(R-MMU-1362302)
phospho-p-T14,T161-CDK1 [nucleoplasm]
(R-MMU-170078)
phospho-p-Y4-CDK1 [cytosol]
(R-MMU-9836187)
CDK1 [endoplasmic reticulum membrane]
(R-MMU-264424)
0.623
4
UniProt:P0DTC2 S
20
S(686-815) [plasma membrane]
(R-COV-9770188)
Spike S2' Fragment [plasma membrane]
(R-COV-9770189)
S1 [plasma membrane]
(R-COV-9769950)
fully glycosylated Spike [plasma membrane]
(R-COV-9733472)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9766369)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9697006)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
(R-COV-9769952)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
0.59
2
UniProt:O75618-1 DEDD
0.576
3
UniProt:Q12778 FOXO1
5
p-S218-FOXO1 [nucleoplasm]
(R-HSA-5692651)
Ac-K245,K248,K265-FOXO1 [nucleoplasm]
(R-HSA-9626942)
FOXO1 [nucleoplasm]
(R-HSA-199300)
p-T24,S256,S319-FOXO1 [nucleoplasm]
(R-HSA-199306)
p-T24,S256,S319-FOXO1 [cytosol]
(R-HSA-211158)
0.571
2
UniProt:Q9NPG2 NGB
1
NGB [cytosol]
(R-HSA-5216004)
0.527
2
UniProt:P12004 PCNA
5
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
PCNA [nucleoplasm]
(R-HSA-68439)
0.527
3
UniProt:Q9NPC3 CIP1
0.527
2
UniProt:Q8N4Q0 PTGR3
0.527
2
UniProt:Q9H5V7 IKZF5
0.527
2
UniProt:P50613 CDK7
1
CDK7 [nucleoplasm]
(R-HSA-69218)
0.527
2
UniProt:O60256 KPRB
0.527
2
UniProt:Q9NVD7 PARVA
1
PARVA [cytosol]
(R-HSA-432848)
0.527
2
UniProt:Q13635 PTCH1
4
PTCH1 [plasma membrane]
(R-HSA-445133)
ub-PTCH1 [endocytic vesicle membrane]
(R-HSA-5632520)
ub-PTCH1 [ciliary membrane]
(R-HSA-5632517)
PTCH1 [ciliary membrane]
(R-HSA-5610415)
0.499
2
UniProt:Q9UM11 FZR1
4
FZR1 [cytosol]
(R-HSA-174249)
FZR1 [nucleoplasm]
(R-HSA-174099)
p-FZR1 [nucleoplasm]
(R-HSA-174257)
p-FZR1 [cytosol]
(R-HSA-174193)
0.483
3
UniProt:Q14674 ESPL1
4
ESPL1(1-1506) [cytosol]
(R-HSA-2467768)
ESPL1(1507-1535) [cytosol]
(R-HSA-2500272)
ESPL1(1536-2120) [cytosol]
(R-HSA-2467767)
ESPL1 [cytosol]
(R-HSA-1638167)
0.462
2
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