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Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes

Stable Identifier
R-HSA-170070
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

WEE1, a nuclear kinase, phosphorylates cyclin B1:Cdc2 (CCNB1:CDK1) on tyrosine 15 (Y15), inactivating the complex (Parker and Piwnica-Worms 1992, McGowan and Russell 1993). The complex of cyclin B2 and Cdc2 (CCNB2:CDK1) is also phosphorylated on Y15 (Galaktionov and Beach 1991).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
kinase activity of WEE1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events