Reactome: A Curated Pathway Database

Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes

Stable Identifier
R-HSA-170070
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

WEE1, a nuclear kinase, phosphorylates cyclin B1:Cdc2 (CCNB1:CDK1) on tyrosine 15 (Y15), inactivating the complex (Parker and Piwnica-Worms 1992, McGowan and Russell 1993). The complex of cyclin B2 and Cdc2 (CCNB2:CDK1) is also phosphorylated on Y15 (Galaktionov and Beach 1991).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
kinase activity of WEE1 [nucleoplasm] WEE1 [nucleoplasm] kinase activity (0016301)
Orthologous Events