Reactome | CDK1 [cytosol]

CDK1 [cytosol]

Stable Identifier

R-HSA-170075

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cdc2

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)
        
        SFN dimer binds CDK1 and CCNB1 (Homo sapiens)
        
        CCNB1:CDK1 [cytosol] (Homo sapiens)
        
        CDK1 [cytosol] (Homo sapiens)
        
        SFN Dimer:CCNB1:CDK1 [cytosol] (Homo sapiens)
        
        CCNB1:CDK1 [cytosol] (Homo sapiens)
        
        CDK1 [cytosol] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CDK1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CDK1 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        CDK1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CDK1 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CDK1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CDK1 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CDK1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CDK1 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CDK1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CDK1 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CDK1 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CDK1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CDK1 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CDK1 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CDK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P06493 CDK1

Gene Names

CDK1, CDC2, CDC28A, CDKN1, P34CDC2

Chain

chain:1-297

Reference Genes

BioGPS Gene:983 CDK1

COSMIC (genes):CDK1 CDK1

CTD Gene:983 CDK1

dbSNP Gene:983 CDK1

ENSEMBL:ENSG00000170312 CDK1

HGNC:1722 CDK1

KEGG:hsa:983 CDK1

Monarch:983 CDK1

NCBI Gene:983 CDK1

OMIM:116940 CDK1

UCSC:P06493 CDK1

Reference Transcript

Other Identifiers

11726617_s_at

11745843_a_at

11760142_at

16705159

1803_at

203213_PM_at

203213_at

203214_PM_x_at

203214_x_at

210559_PM_s_at

210559_s_at

3248301

3248302

3248303

3248304

3248306

3248307

3248308

3248309

3248310

3248311

3248312

3248313

3248314

3248315

3248316

3248318

3248319

3248320

3248322

33324_s_at

40915_r_at

7927710

91194_at

983

A_14_P116805

A_21_P0000076

A_23_P138507

GE63002

GO:0000082

GO:0000086

GO:0000226

GO:0000307

GO:0000781

GO:0001618

GO:0003682

GO:0003824

GO:0004672

GO:0004674

GO:0004693

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005759

GO:0005789

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005876

GO:0006260

GO:0006281

GO:0006325

GO:0006338

GO:0006355

GO:0006357

GO:0006468

GO:0006915

GO:0006974

GO:0007010

GO:0007077

GO:0007095

GO:0007098

GO:0007344

GO:0008353

GO:0009410

GO:0009636

GO:0010628

GO:0010629

GO:0010971

GO:0012501

GO:0014038

GO:0014070

GO:0014075

GO:0014823

GO:0016020

GO:0016301

GO:0016477

GO:0016579

GO:0016740

GO:0018105

GO:0018107

GO:0030154

GO:0030261

GO:0030332

GO:0030496

GO:0030544

GO:0030855

GO:0031100

GO:0034501

GO:0035173

GO:0042307

GO:0042542

GO:0042752

GO:0043066

GO:0043226

GO:0044772

GO:0045471

GO:0045740

GO:0045931

GO:0045995

GO:0046686

GO:0046688

GO:0046718

GO:0048144

GO:0048511

GO:0048678

GO:0048856

GO:0048870

GO:0051301

GO:0055015

GO:0060045

GO:0061024

GO:0062033

GO:0065003

GO:0070062

GO:0070301

GO:0070371

GO:0071407

GO:0072686

GO:0090166

GO:0097121

GO:0097122

GO:0097125

GO:0097472

GO:0106310

GO:0140096

GO:1900182

GO:1902423

GO:1902850

GO:1905448

HMNXSV003002530

HMNXSV003023507

Hs.184572.0.S2_3p_at

ILMN_1710428

ILMN_1747911

PH_hs_0016443

TC10000373.hg

X05360_at

g3126638_3p_a_at

Participates

as a component of

as an input of

Other forms of this molecule

p-T161-CDK1 [nucleoplasm]

p-T14,Y15,T161-CDK1 [nucleoplasm]

p-T161-CDK1 [cytosol]

p-T14,Y15,T161-CDK1 [cytosol]

CDK1 [nucleoplasm]

p-T14-CDK1 [cytosol]

p-T14-CDK1 [nucleoplasm]

p-T14,T161-CDK1 [nucleoplasm]

p-Y4-CDK1 [cytosol]

CDK1 [endoplasmic reticulum membrane]

Inferred To

CDK1 [cytosol] (Bos taurus)

CDK1 [cytosol] (Caenorhabditis elegans)

CDK1 [cytosol] (Canis familiaris)

CDK1 [cytosol] (Danio rerio)

CDK1 [cytosol] (Drosophila melanogaster)

CDK1 [cytosol] (Gallus gallus)

CDK1 [cytosol] (Mus musculus)

CDK1 [cytosol] (Rattus norvegicus)

CDK1 [cytosol] (Sus scrofa)

CDK1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001307847.1, NP_203698.1, NP_001777.1, XP_005270360.1

ZINC - World Drugs

CDK1_HUMAN

Guide to Pharmacology - Targets

1961

OpenTargets

ENSG00000170312

ENSEMBL

ENST00000373809, ENSP00000378699, ENST00000316629, ENSP00000362915, ENST00000395284, ENSP00000325970

ZINC - Substances

CDK1_HUMAN

ZINC - Biogenic

CDK1_HUMAN

ZINC target

P06493

PRO

P06493

GlyGen

P06493

PDB

6GU4, 4Y72, 4YC6, 6GU7, 5HQ0, 6GU6, 5LQF, 4YC3, 6TWN, 7NJ0, 6GU3, 6GU2

ZINC - Investigational

CDK1_HUMAN

ZINC - Metabolites

CDK1_HUMAN

HPA

ENSG00000170312-CDK1

Pharos - Targets

P06493

ZINC - Predictions - Purchasable

CDK1_HUMAN

HMDB Protein

HMDBP01364

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14635 CCNB1	4	CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049) CCNB1 [cytosol] (R-HSA-157451)	0.976	28
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.924	13
UniProt:P38936 CDKN1A	5	p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) CDKN1A [nucleoplasm] (R-HSA-182585) CDKN1A [cytosol] (R-HSA-182512) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.903	10
UniProt:Q99640 PKMYT1	3	PKMYT1 [cytosol] (R-HSA-157457) p-PKMYT1 [nucleoplasm] (R-HSA-162650) PKMYT1 [nucleoplasm] (R-HSA-74386)	0.893	9
UniProt:P46527 CDKN1B	8	p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.886	9
UniProt:P33552 CKS2			0.837	9
UniProt:P20248 CCNA2	3	CCNA2 [nucleoplasm] (R-HSA-68905) CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099)	0.837	9
UniProt:O95067 CCNB2	1	CCNB2 [cytosol] (R-HSA-68897)	0.837	10
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.725	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.667	3
UniProt:Q12778 FOXO1	5	FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651)	0.645	5
UniProt:P30281 CCND3	2	CCND3 [nucleoplasm] (R-HSA-113835) CCND3 [cytosol] (R-HSA-68333)	0.643	4
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811)	0.643	3
UniProt:O95835 LATS1	2	LATS1 [cytosol] (R-HSA-2028562) p-S909,T1079-LATS1 [cytosol] (R-HSA-2028551)	0.632	3
UniProt:P30307 CDC25C	8	p-S198-CDC25C [nucleoplasm] (R-HSA-156668) p-S198-CDC25C [cytosol] (R-HSA-8981697) CDC25C [cytosol] (R-HSA-157879) CDC25C [nucleoplasm] (R-HSA-69741) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) p-S216-CDC25C [cytosol] (R-HSA-75003) p-S191-CDC25C [nucleoplasm] (R-HSA-6802968) p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654)	0.623	3
UniProt:P27986-2 PIK3R1			0.556	3
UniProt:O43508 TNFSF12	2	TNFSF12 [plasma membrane] (R-HSA-5667154) sTNFSF12 [extracellular region] (R-HSA-5675974)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q16667 CDKN3			0.553	2
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.527	2
UniProt:Q00537 CDK17			0.527	3
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.527	2
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.527	2
UniProt:O75496 GMNN	2	GMNN [nucleoplasm] (R-HSA-113554) PolyUb-GMNN [nucleoplasm] (R-HSA-68585)	0.527	2
UniProt:Q9H211 CDT1	1	CDT1 [nucleoplasm] (R-HSA-68536)	0.527	2
UniProt:Q00526 CDK3			0.527	3
UniProt:Q99741 CDC6	4	CDC6 [cytosol] (R-HSA-113566) p-CDC6 [cytosol] (R-HSA-68583) p-CDC6 [nucleoplasm] (R-HSA-5661317) CDC6 [nucleoplasm] (R-HSA-68542)	0.524	2
UniProt:Q86V81 ALYREF	2	ALYREF [cytosol] (R-HSA-158482) ALYREF [nucleoplasm] (R-HSA-156649)	0.499	4
UniProt:P21796 VDAC1	7	p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-HSA-9834991) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-9834037) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) Ub-VDAC1 [mitochondrial outer membrane] (R-HSA-9834989) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079)	0.499	3
UniProt:O75618-1 DEDD			0.499	2
UniProt:P36957 DLST	5	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) DLST [mitochondrial matrix] (R-HSA-6792574) GlutaryllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9858581)	0.499	3
UniProt:P01732 CD8A	1	CD8A [plasma membrane] (R-HSA-197601)	0.488	2
UniProt:P11362 FGFR1	9	FGFR1 [plasma membrane] (R-HSA-9756433) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) FGFR1 R576W [plasma membrane] (R-HSA-2011844) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241)	0.483	3
UniProt:Q96GD4 AURKB	3	AURKB [cytosol] (R-HSA-174231) AURKB [nucleoplasm] (R-HSA-4655360) polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414)	0.463	5
UniProt:O15392 BIRC5	3	BIRC5 [cytosol] (R-HSA-50851) BIRC5 [nucleoplasm] (R-HSA-4655344) ub-BIRC5 [cytosol] (R-HSA-8955933)	0.463	6
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.463	2
UniProt:A0A096LP01 SIM26			0.462	2

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