Reactome: A Curated Pathway Database

CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes

Stable Identifier
R-HSA-170076
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Full activity of most CDKs is dependent on CAK mediated phosphorylation at a conserved residue (Thr161 in Cdc2). This modification is thought to improve substrate binding. Cyclin B:Cdc2 complexes have considerably low activity in the absence of CAK mediated phosphorylation (Desai et al 1995).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
kinase activity of CAK [nucleoplasm] CAK [nucleoplasm] kinase activity (0016301)
Orthologous Events