CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes

Stable Identifier
R-HSA-170087
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Full activity of most CDKs is dependent on CAK mediated phosphorylation at a conserved residue (Thr 161 in Cdc2). This modification is thought to improve substrate binding. High affinity binding of Cyclin A within the Cyclin A:Cdc2 complex requires this phosphorylation (Desai et al 1995).
Literature References
PubMed ID Title Journal Year
7799941 Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2.

Wessling, HC, Desai, D, Fisher, RP, Morgan, DO

Mol Cell Biol 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of CAK [nucleoplasm]

Physical Entity
CAK [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Bos taurus)
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Canis familiaris)
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Drosophila melanogaster)
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Gallus gallus)
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Mus musculus)
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Rattus norvegicus)
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Sus scrofa)
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Xenopus tropicalis)
Created
Matthews, L  (2005-12-23)
Cite Us!