CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes

Stable Identifier
R-HSA-170087
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Full activity of most CDKs is dependent on CAK mediated phosphorylation at a conserved residue (Thr 161 in Cdc2). This modification is thought to improve substrate binding. High affinity binding of Cyclin A within the Cyclin A:Cdc2 complex requires this phosphorylation (Desai et al 1995).

Literature References
PubMed ID Title Journal Year
7799941 Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2. Mol Cell Biol 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
kinase activity of CAK [nucleoplasm]
Physical Entity
Activity
Orthologous Events