Phosphorylation of Cyclin B1 in the CRS domain

Stable Identifier
R-HSA-170126
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

At the onset of mitosis, cyclin B is phosphorylated in the CRS sequence which creates a nuclear import signal in the amino terminus. The kinase(s) responsible for this phosphorylation are not yet known (Hagting et al., 1999).

Literature References
PubMed ID Title Journal Year
10395539 Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal

Hagting, A, Jackman, M, Simpson, K, Pines, J

Curr Biol 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
kinase activity of CRS kinase [cytosol]
Physical Entity
Activity
Orthologous Events