Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes

Stable Identifier
R-HSA-170131
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The rapid translocation of cyclin B1:Cdc2 from the cytoplasm to the nucleus at the onset of mitosis is a result of an increase in the rate of import and, likely, a decreased rate of export. The increased rate of nuclear import is dependent upon phosphorylation of the CRS which creates a nuclear import signal in the amino terminus of cyclin B1 (Hagting et al, 1999).

Literature References
Participants
Participant Of
Orthologous Events