Reactome | Translocation of active Cdc25C to the nucleus

Translocation of active Cdc25C to the nucleus

Stable Identifier

R-HSA-170149

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nuclear envelope

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Translocation of active Cdc25C to the nucleus

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During interphase, CDC25C, phosphorylated on serine residue 216, is associated with 14-3-3 proteins, preventing nuclear import. At the onset of mitosis, dephosphorylation of S216 of Cdc25C and dissociation of 14-3-3, with phosphorylation of CDC25C on S198 by activated PLK1 promotes nuclear import (Takizawa and Morgan 2000, Toyoshima-Morimoto et al. 2002, Bonnet et al. 2008). Activating CDC25C phosphorylation and nuclear translocation may further be enhanced by activated CCNB:CDK1 complexes (Bonnet et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18384749	Differential phosphorylation of Cdc25C phosphatase in mitosis Bonnet, J, Mayonove, P, Morris, MC	Biochem. Biophys. Res. Commun.	2008
11063929	Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C Takizawa, CG, Morgan, DO	Curr Opin Cell Biol	2000
11897663	Plk1 promotes nuclear translocation of human Cdc25C during prophase Toyoshima-Morimoto, F, Taniguchi, E, Nishida, E	EMBO Rep	2002