Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes

Stable Identifier
R-HSA-170158
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes
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Activation of the cyclin A:Cdc2 complexes at mitosis requires the removal of the inhibitory phosphate groups on Cdc2 (CDK1). This dephosphorylation is achieved by the activity of the CDC25A phosphatase (Timofeev et al. 2009). CDC25A, CDC25B, and CDC25C are kept inactive during interphase and are activated at the G2/M transition (see Wolfe and Gould 2004).
Literature References
PubMed ID Title Journal Year
19192479 Human Cdc25A phosphatase has a non-redundant function in G2 phase by activating Cyclin A-dependent kinases

Hoffmann, I, Orlik, T, Cizmecioglu, O, Timofeev, O, Hu, E

FEBS Lett. 2009
Participants
Input
Output
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as an event of
Catalyst Activity

phosphoprotein phosphatase activity of CDC25A [nucleoplasm]

Physical Entity
CDC25A [nucleoplasm] (Homo sapiens)
Activity
phosphoprotein phosphatase activity (GO:0004721)
Orthologous Events
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Bos taurus)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Caenorhabditis elegans)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Canis familiaris)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Drosophila melanogaster)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Gallus gallus)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Mus musculus)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Rattus norvegicus)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Sus scrofa)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Xenopus tropicalis)
Created
Matthews, L  (2005-12-23)
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