Adenylate cyclase increases the GTPase activity of Gi alpha

Stable Identifier
R-HSA-170686
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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G proteins can deactivate themselves via their intrinsic GTPase activity, which hydrolyzes GTP to GDP. Effectors such as adenylate cyclase can increase the G protein GTPase rate, acting like GTPase-activating proteins (GAPs).
Literature References
PubMed ID Title Journal Year
7937899 Mechanism of GTP hydrolysis by G-protein alpha subunits

Kleuss, C, Gilman, AG, Sprang, SR, Raw, AS, Lee, E

Proc Natl Acad Sci U S A 1994
Participants
Participates
Catalyst Activity

GTPase activity of (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane]

Orthologous Events
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