Reactome | TGFB1 [extracellular region]

TGFB1 [extracellular region]

Stable Identifier

R-HSA-170838

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

TGF-beta-1, Transforming Growth Factor beta 1

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Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
    - Platelet degranulation (Homo sapiens)
      - Exocytosis of platelet alpha granule contents (Homo sapiens)
        
        Platelet alpha granule contents [extracellular region] (Homo sapiens)
        
        TGF beta [extracellular region] (Homo sapiens)
        
        TGFB1 [extracellular region] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - UCH proteinases (Homo sapiens)
      - UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
        
        TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
        
        TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
        
        TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
        
        TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
        
        Dimeric TGFB1 [extracellular region] (Homo sapiens)
        
        TGFB1 [extracellular region] (Homo sapiens)
        
        TGFB1:TGFBR2:p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
        
        TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
        
        TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
        
        Dimeric TGFB1 [extracellular region] (Homo sapiens)
        
        TGFB1 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01137 TGFB1

Gene Names

TGFB1, TGFB

Chain

signal peptide:1-29, chain:30-278, chain:279-390

Reference Genes

BioGPS Gene:7040 TGFB1

COSMIC (genes):TGFB1 TGFB1

CTD Gene:7040 TGFB1

dbSNP Gene:7040 TGFB1

ENSEMBL:ENSG00000105329 TGFB1

HGNC:11766 TGFB1

KEGG:hsa:7040 TGFB1

Monarch:7040 TGFB1

NCBI Gene:7040 TGFB1

OMIM:190180 TGFB1

UCSC:P01137 TGFB1

Reference Transcript

RefSeq:NM_000660.6 TGFB1

Other Identifiers

11716385_at

11723396_at

1634_s_at

16872551

1830_s_at

203084_PM_at

203084_at

203085_PM_s_at

203085_s_at

219766_PM_at

219766_at

3863022

3863024

3863028

3863029

3863030

3863031

3863032

3863033

3863034

3863035

3863036

3863037

3863038

3863039

3863040

3863047

3863048

41445_at

7040

76345_r_at

8037005

A_23_P218476

A_24_P79054

A_24_P96171

GE59644

GO:0000122

GO:0000902

GO:0001570

GO:0001657

GO:0001666

GO:0001763

GO:0001775

GO:0001837

GO:0001843

GO:0001933

GO:0002028

GO:0002040

GO:0002062

GO:0002069

GO:0002244

GO:0002248

GO:0002376

GO:0002460

GO:0002513

GO:0002859

GO:0003013

GO:0003179

GO:0003180

GO:0005114

GO:0005125

GO:0005160

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005796

GO:0005886

GO:0005902

GO:0006355

GO:0006611

GO:0006754

GO:0006796

GO:0006874

GO:0006886

GO:0006913

GO:0006954

GO:0007165

GO:0007179

GO:0007219

GO:0007406

GO:0007435

GO:0007492

GO:0007507

GO:0007565

GO:0008083

GO:0008283

GO:0008284

GO:0008285

GO:0008354

GO:0009410

GO:0009611

GO:0009749

GO:0009986

GO:0010467

GO:0010468

GO:0010575

GO:0010628

GO:0010629

GO:0010716

GO:0010718

GO:0010742

GO:0010763

GO:0010936

GO:0012501

GO:0014003

GO:0014008

GO:0014070

GO:0016202

GO:0019899

GO:0021915

GO:0022408

GO:0022414

GO:0030141

GO:0030154

GO:0030198

GO:0030214

GO:0030217

GO:0030279

GO:0030308

GO:0030312

GO:0030316

GO:0030334

GO:0030335

GO:0030424

GO:0030879

GO:0031012

GO:0031093

GO:0031100

GO:0031293

GO:0031334

GO:0031410

GO:0031536

GO:0032355

GO:0032570

GO:0032667

GO:0032700

GO:0032740

GO:0032755

GO:0032760

GO:0032801

GO:0032930

GO:0032943

GO:0032956

GO:0032967

GO:0033280

GO:0034330

GO:0034616

GO:0034713

GO:0034714

GO:0035307

GO:0035800

GO:0035902

GO:0036446

GO:0042098

GO:0042110

GO:0042127

GO:0042130

GO:0042306

GO:0042307

GO:0042475

GO:0042482

GO:0042552

GO:0042802

GO:0043025

GO:0043029

GO:0043065

GO:0043117

GO:0043123

GO:0043129

GO:0043226

GO:0043410

GO:0043536

GO:0043537

GO:0043539

GO:0044877

GO:0045066

GO:0045216

GO:0045589

GO:0045591

GO:0045596

GO:0045599

GO:0045662

GO:0045742

GO:0045786

GO:0045892

GO:0045893

GO:0045944

GO:0046716

GO:0048018

GO:0048146

GO:0048286

GO:0048298

GO:0048535

GO:0048565

GO:0048642

GO:0048661

GO:0048839

GO:0048856

GO:0048870

GO:0050673

GO:0050679

GO:0050680

GO:0050714

GO:0050729

GO:0050731

GO:0050765

GO:0050832

GO:0050868

GO:0050921

GO:0051152

GO:0051247

GO:0051280

GO:0051402

GO:0051726

GO:0051781

GO:0051897

GO:0055010

GO:0055086

GO:0055091

GO:0060070

GO:0060312

GO:0060325

GO:0060364

GO:0060391

GO:0060435

GO:0060744

GO:0060751

GO:0060762

GO:0061035

GO:0061298

GO:0061448

GO:0061520

GO:0062023

GO:0070168

GO:0070173

GO:0070306

GO:0070374

GO:0070723

GO:0071260

GO:0071333

GO:0071363

GO:0071404

GO:0071456

GO:0071479

GO:0071549

GO:0071560

GO:0071677

GO:0071895

GO:0072089

GO:0072562

GO:0085029

GO:0090190

GO:0090263

GO:0097191

GO:0097421

GO:0098542

GO:0098586

GO:0098772

GO:1900126

GO:1900182

GO:1901135

GO:1901203

GO:1902074

GO:1902462

GO:1902894

GO:1902895

GO:1903077

GO:1904018

GO:1904894

GO:1905641

GO:1990314

GO:1990402

GO:2000343

GO:2000353

GO:2000636

GO:2000648

GO:2000727

HMNXSV003021647

HMNXSV003021863

ILMN_1806999

ILMN_2129668

M38449_s_at

TC19001553.hg

TC19002485.hg

X05839_rna1_s_at

g10863872_3p_at

g12652748_3p_a_at

g13385567_3p_at

Participates

as a member of

as a component of

as an input of

Syndecans 2, (4) bind TGFB1 (Homo sapiens)

This entity regulates

Negatively

Other forms of this molecule

TGFB1(30-278) [extracellular region]

TGFB1(30-278) [Golgi lumen]

TGFB1 [Golgi lumen]

TGFB1(30-390) [Golgi lumen]

TGFB1 [plasma membrane]

TGFB1(30-278) [platelet alpha granule lumen]

Inferred To

B9D2 [extracellular region] (Canis familiaris)

TGFB1 [extracellular region] (Bos taurus)

TGFB1 [extracellular region] (Gallus gallus)

TGFB1 [extracellular region] (Sus scrofa)

tgfb1a [extracellular region] (Danio rerio)

mav [extracellular region] (Drosophila melanogaster)

dbl-1 [extracellular region] (Caenorhabditis elegans)

Tgfb1 [extracellular region] (Mus musculus)

Tgfb1 [extracellular region] (Rattus norvegicus)

daf-7 [extracellular region] (Caenorhabditis elegans)

Ghost homologue of TGFB1 [extracellular region] (Xenopus tropicalis)

Homologues of TGFB1 [extracellular region] (Caenorhabditis elegans)

Homologues of TGFB1 [extracellular region] (Drosophila melanogaster)

dpp [extracellular region] (Drosophila melanogaster)

unc-129 [extracellular region] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000651.3

OpenTargets

ENSG00000105329

ENSEMBL

ENSP00000221930, ENST00000221930

ZINC - Substances

TGFB1_HUMAN

ZINC target

P01137

PRO

P01137

Pharos - Targets

P01137

Orphanet

TGFB1

ZINC - Predictions - Purchasable

TGFB1_HUMAN

HMDB Protein

HMDBP14566

PDB

4KV5, 7Y1T, 6OM2, 6P7J, 3KFD, 7Y1R, 1KLD, 1KLA, 1KLC, 5FFO, 5VQP

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.886	11
UniProt:Q14392 LRC32			0.669	4
UniProt:Q14766-1 LTBP1			0.637	4
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.604	3
UniProt:P11464 PSG1	1	PSG1 [extracellular region] (R-HSA-8870766)	0.558	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
IntAct:EBI-10171584 80125			0.556	3
UniProt:Q12837 POU4F2	1	POU4F2 [nucleoplasm] (R-HSA-6804414)	0.556	3
UniProt:Q5TA77 LCE3B	1	LCE3B [cytosol] (R-HSA-6814269)	0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:Q9BYQ6 KRTAP4-11	1	KRTAP4-11 [cytosol] (R-HSA-6809960)	0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:A0A0C3SFZ9 A0A0C3SFZ9			0.556	3
UniProt:Q5TA76 LCE3A	1	LCE3A [cytosol] (R-HSA-6814296)	0.556	3
UniProt:Q5T7P2 LCE1A	1	LCE1A [cytosol] (R-HSA-6814305)	0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:Q5T752 LCE1D	1	LCE1D [cytosol] (R-HSA-6814283)	0.556	3
UniProt:Q5T751 LCE1C	1	LCE1C [cytosol] (R-HSA-6814267)	0.556	3
UniProt:Q9BYE3 LCE3D	1	LCE3D [cytosol] (R-HSA-6814297)	0.556	3
UniProt:Q8NEC5 CATSPER1	1	CATSPER1 [plasma membrane] (R-HSA-2534335)	0.556	3
IntAct:EBI-22335676 CCSB ORF ID			0.556	3
UniProt:O14633 LCE2B	1	LCE2B [cytosol] (R-HSA-6814295)	0.556	3
UniProt:Q5TA81 LCE2C	1	LCE2C [cytosol] (R-HSA-6814284)	0.556	3
UniProt:O60711 LPXN			0.556	3
UniProt:Q8IUG1 KRTAP1-3	1	KRTAP1-3 [cytosol] (R-HSA-6809866)	0.556	3
UniProt:Q12841 FSTL1	3	FSTL1 [extracellular region] (R-HSA-201832) p-FSTL1 [endoplasmic reticulum lumen] (R-HSA-8957089) FSTL1 [endoplasmic reticulum lumen] (R-HSA-8956749)	0.544	2
UniProt:P22105 TNXB	1	TNXB [extracellular region] (R-HSA-2672026)	0.544	3
UniProt:O60551 NMT2	1	NMT2 [cytosol] (R-HSA-184377)	0.527	3
UniProt:P59665 DEFA1	9	DEFA1(20-94) [Golgi lumen] (R-HSA-1467282) DEFA1(66-94) [Golgi lumen] (R-HSA-975663) DEFA1(20-65) [Golgi lumen] (R-HSA-8864970) DEFA1(1-94) [Golgi lumen] (R-HSA-1467215) DEFA1(66-94) [extracellular region] (R-HSA-1461998) DEFA1(66-94) [azurophil granule lumen] (R-HSA-1470038) DEFA1(65-94) [extracellular region] (R-HSA-1462022) omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region] (R-HSA-1972397) DEFA1(65-94) [azurophil granule lumen] (R-HSA-1470053)	0.527	2
UniProt:Q9BS26 ERP44	2	ERP44 [extracellular region] (R-HSA-6806302) ERP44 [specific granule lumen] (R-HSA-6799567)	0.527	3
UniProt:O15496 PLA2G10	1	PLA2G10 [extracellular region] (R-HSA-1498793)	0.527	2
UniProt:P11047 LAMC1	3	LAMC1 [extracellular region] (R-HSA-215962) p-LAMC1 [endoplasmic reticulum lumen] (R-HSA-8956921) LAMC1 [endoplasmic reticulum lumen] (R-HSA-8956712)	0.527	4
UniProt:Q8IWV7 UBR1	1	UBR1 [cytosol] (R-HSA-976040)	0.527	4
UniProt:Q86YC3 LRC33			0.527	2
UniProt:P07996 THBS1	5	THBS1 [endoplasmic reticulum lumen] (R-HSA-5173263) glc-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5172997) O-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5173278) THBS1 [platelet alpha granule lumen] (R-HSA-114701) THBS1 [extracellular region] (R-HSA-66518)	0.525	2
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.522	2
UniProt:P06756 ITGAV	3	ITGAV(31-1048) [plasma membrane] (R-HSA-210013) ITGAV(31-1048) [specific granule membrane] (R-HSA-6806145) ITGAV(31-1048) [phagocytic vesicle] (R-HSA-1236773)	0.488	2

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