Activated type I receptor phosphorylates SMAD2/3 directly

Stable Identifier
R-HSA-170868
Type
Reaction [transition]
Species
Homo sapiens
Compartment
early endosome membrane
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Activated type I receptor phosphorylates SMAD2/3 directly
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Activated type I receptor kinase directly phosphorylates two of the C-terminal serine residues of SMAD1, SMAD5 or SMAD8. Binding of these R-SMADs to the L45 loop of the type I receptor is critical for this event.

Literature References
PubMed ID Title Journal Year
11100470 Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases

Souchelnytskyi, S, Rönnstrand, L, Heldin, CH, ten Dijke, P

Methods Mol Biol 2001
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein serine/threonine kinase activity of TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane]
Physical Entity
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane]
Activity
transmembrane receptor protein serine/threonine kinase activity (0004675)
Orthologous Events
Activated type I receptor phosphorylates SMAD2/3 directly (Bos taurus)
Activated type I receptor phosphorylates SMAD2/3 directly (Caenorhabditis elegans)
Activated type I receptor phosphorylates SMAD2/3 directly (Canis familiaris)
Activated type I receptor phosphorylates SMAD2/3 directly (Danio rerio)
Activated type I receptor phosphorylates SMAD2/3 directly (Drosophila melanogaster)
Activated type I receptor phosphorylates SMAD2/3 directly (Gallus gallus)
Activated type I receptor phosphorylates SMAD2/3 directly (Mus musculus)
Activated type I receptor phosphorylates SMAD2/3 directly (Rattus norvegicus)
Activated type I receptor phosphorylates SMAD2/3 directly (Xenopus tropicalis)
Authored
Heldin, CH  (2006-02-02)
Moustakas, A  (2006-02-02)
Huminiecki, L  (2006-02-02)
Jassal, B  (2006-02-02)
Reviewed
Heldin, CH  (2006-04-18)
Huang, T  (2012-05-14)
Created
Jassal, B  (2006-01-18)