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MAPK11 [cytosol]
Stable Identifier
R-HSA-170989
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MAP kinase p38 beta
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Myogenesis (Homo sapiens)
Activation of p38 alpha/beta MAPK (Homo sapiens)
p38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
p38 MAPK alpha/beta/gamma [cytosol] (Homo sapiens)
MAPK11 [cytosol] (Homo sapiens)
Interaction of p38 MAPK with JLP (Homo sapiens)
p38 MAPK alpha/beta/gamma [cytosol] (Homo sapiens)
MAPK11 [cytosol] (Homo sapiens)
p38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
p38 MAPK alpha/beta/gamma [cytosol] (Homo sapiens)
MAPK11 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
NOD1/2 Signaling Pathway (Homo sapiens)
Activation of p38 MAPK (Homo sapiens)
p38 MAPK [cytosol] (Homo sapiens)
MAPK11 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Signalling to RAS (Homo sapiens)
p38MAPK events (Homo sapiens)
Binding and activation of MAP Kinase (Homo sapiens)
MAP kinase p38 (Mg2+ cofactor) [cytosol] (Homo sapiens)
MAP kinase p38 [cytosol] (Homo sapiens)
MAPK11 [cytosol] (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
p38 MAPK activation by VEGFR (Homo sapiens)
MAP kinase p38 (Mg2+ cofactor) [cytosol] (Homo sapiens)
MAP kinase p38 [cytosol] (Homo sapiens)
MAPK11 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15759 MAPK11
Gene Names
MAPK11, PRKM11, SAPK2, SAPK2B
Chain
chain:1-364
Reference Genes
BioGPS Gene:5600 MAPK11
COSMIC (genes):MAPK11 MAPK11
CTD Gene:5600 MAPK11
dbSNP Gene:5600 MAPK11
ENSEMBL:ENSG00000185386 MAPK11
ENSEMBL_homo_sapiens_GENE:ENSG00000185386.15 MAPK11
HGNC:6873 MAPK11
KEGG Gene (Homo sapiens):5600 MAPK11
Monarch:5600 MAPK11
NCBI Gene:5600 MAPK11
OMIM:602898 MAPK11
UCSC:Q15759 MAPK11
Reference Transcript
RefSeq:NM_002751.6 MAPK11
Other Identifiers
1010_at
11730965_a_at
11730966_at
16936432
206040_PM_s_at
206040_s_at
211499_PM_s_at
211499_s_at
211500_PM_at
211500_at
3965783
3965785
3965786
3965787
3965788
3965789
3965790
3965791
3965793
3965795
3965797
3965798
3965800
3965801
3965802
3965803
3965804
3965805
3965806
3965807
3965808
40033_at
5600
8076978
A_23_P502274
A_33_P3409508
A_33_P3409513
GE88364
GO:0000165
GO:0000166
GO:0001649
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006468
GO:0010628
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0031098
GO:0032735
GO:0035556
GO:0036211
GO:0038066
GO:0043226
GO:0048856
GO:0051149
GO:0051403
GO:0060038
GO:0060043
GO:0060044
GO:0060348
GO:0071347
GO:0071493
GO:0090398
GO:0098586
GO:0106310
GO:0140096
HMNXSV003058003
ILMN_1724715
ILMN_1735361
PH_hs_0003700
TC22000910.hg
U53442_at
g1469305_3p_at
g1469305_3p_x_at
g2316011_3p_a_at
g4506082_3p_a_at
Participates
as a member of
p38 MAPK alpha/beta/gamma [cytosol] (Homo sapiens)
MAP kinase p38 [cytosol] (Homo sapiens)
as a candidate of
p38 MAPK [cytosol] (Homo sapiens)
Other forms of this molecule
p-T180,Y182-MAPK11 [cytosol]
MAPK11 [nucleoplasm]
p-T180,Y182-MAPK11 [nucleoplasm]
Inferred To
MAPK11 [cytosol]
(Bos taurus)
MAPK11 [cytosol]
(Caenorhabditis elegans)
MAPK11 [cytosol]
(Canis familiaris)
MAPK11 [cytosol]
(Danio rerio)
MAPK11 [cytosol]
(Dictyostelium discoideum)
MAPK11 [cytosol]
(Drosophila melanogaster)
MAPK11 [cytosol]
(Saccharomyces cerevisiae)
MAPK11 [cytosol]
(Schizosaccharomyces pombe)
MAPK11 [cytosol]
(Sus scrofa)
MAPK11 [cytosol]
(Xenopus tropicalis)
Mapk11 [cytosol]
(Rattus norvegicus)
MAP kinase p38 beta [cytosol]
(Mus musculus)
Cross References
RefSeq
NP_002742.3
ZINC - World Drugs
MK11_HUMAN
Guide to Pharmacology - Targets
1500
OpenTargets
ENSG00000185386
ZINC - FDA approved
MK11_HUMAN
ZINC - Substances
MK11_HUMAN
ZINC target
Q15759
PRO
Q15759
PDB
3GC8
,
3GP0
,
3GC9
ZINC - Investigational
MK11_HUMAN
IntEnz
2.7.11.24
HPA
ENSG00000185386-MAPK11
GeneCards
Q15759
Ensembl
ENSP00000333685
,
ENSG00000185386
,
ENST00000395764
,
ENST00000330651
,
ENSP00000379113
Pharos - Targets
Q15759
ZINC - Predictions - Purchasable
MK11_HUMAN
HMDB Protein
HMDBP01336
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P17252 PRKCA
8
PRKCA [cytosol]
(R-HSA-58196)
pT497,T638,S657-PRKCA [plasma membrane]
(R-HSA-4332340)
p-T497,T638,S657-PRKCA [cytosol]
(R-HSA-4332337)
PRKCA [plasma membrane]
(R-HSA-156469)
p-T497-PRKCA [cytosol]
(R-HSA-5218731)
p-T497,T638,S657-PRKCA [nucleoplasm]
(R-HSA-5223292)
PRKCA [photoreceptor disc membrane]
(R-HSA-2648987)
PRKCA [nucleoplasm]
(R-HSA-450530)
0.556
3
UniProt:Q13153 PAK1
5
PAK1 [plasma membrane]
(R-HSA-3928409)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
Active PAK1 [cytosol]
(R-HSA-8964622)
PAK1 [cytosol]
(R-HSA-162629)
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
0.556
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
UniProt:Q16539 MAPK14
7
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [nucleoplasm]
(R-HSA-446223)
MAPK14 [cytosol]
(R-HSA-428933)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
0.547
2
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