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LDLR [endosome membrane]
Stable Identifier
R-HSA-171127
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
LDL receptor, low-density lipoprotein receptor
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein clearance (Homo sapiens)
Chylomicron clearance (Homo sapiens)
chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR (Homo sapiens)
LDLR [endosome membrane] (Homo sapiens)
chylomicron remnant:apoE:LDLR complex [endosome membrane] (Homo sapiens)
LDLR [endosome membrane] (Homo sapiens)
chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane] (Homo sapiens)
chylomicron remnant:apoE:LDLR complex [endosome membrane] (Homo sapiens)
LDLR [endosome membrane] (Homo sapiens)
LDL clearance (Homo sapiens)
LDLR [endosome membrane] => LDLR [plasma membrane] (Homo sapiens)
LDLR [endosome membrane] (Homo sapiens)
LDLR:LDL complex => LDLR + LDL (Homo sapiens)
LDL:LDLR complex [endosome membrane] (Homo sapiens)
LDLR [endosome membrane] (Homo sapiens)
LDLR [endosome membrane] (Homo sapiens)
LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Homo sapiens)
LDL:LDLR complex [endosome membrane] (Homo sapiens)
LDLR [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01130 LDLR
Gene Names
LDLR
Chain
signal peptide:1-21, chain:22-860
Reference Genes
BioGPS Gene:3949 LDLR
COSMIC (genes):LDLR LDLR
CTD Gene:3949 LDLR
dbSNP Gene:3949 LDLR
ENSEMBL:ENSG00000130164 LDLR
ENSEMBL_homo_sapiens_GENE:ENSG00000130164.15 LDLR
HGNC:6547 LDLR
KEGG Gene (Homo sapiens):3949 LDLR
Monarch:3949 LDLR
NCBI Gene:3949 LDLR
OMIM:606945 LDLR
UCSC:P01130 LDLR
Reference Transcript
RefSeq:NM_000527.4 LDLR
RefSeq:NM_001195800.1 LDLR
RefSeq:NM_001195799.1 LDLR
RefSeq:NM_001195798.1 LDLR
RefSeq:NM_001195803.1 LDLR
Other Identifiers
11720028_x_at
11720029_a_at
11746974_a_at
11748045_x_at
16858386
202067_PM_s_at
202067_s_at
202068_PM_s_at
202068_s_at
217173_PM_s_at
217173_s_at
32855_at
3821016
3821017
3821021
3821022
3821023
3821026
3821029
3821031
3821034
3821035
3821036
3821037
3821041
3821042
3821044
3821045
3821046
3821048
3821052
3821054
3821055
3949
8025828
A_14_P117693
A_23_P208595
A_24_P117029
GE61153
GO:0001540
GO:0001618
GO:0001920
GO:0002020
GO:0002376
GO:0005041
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005768
GO:0005769
GO:0005770
GO:0005773
GO:0005794
GO:0005886
GO:0005905
GO:0006629
GO:0006869
GO:0006897
GO:0006898
GO:0006909
GO:0006954
GO:0007616
GO:0008202
GO:0008203
GO:0009897
GO:0009986
GO:0010008
GO:0010628
GO:0010629
GO:0010867
GO:0010899
GO:0010989
GO:0015914
GO:0016020
GO:0016192
GO:0016323
GO:0022600
GO:0023052
GO:0030154
GO:0030163
GO:0030169
GO:0030229
GO:0030299
GO:0030301
GO:0030669
GO:0031410
GO:0032050
GO:0034362
GO:0034381
GO:0034383
GO:0034384
GO:0036020
GO:0036477
GO:0038024
GO:0042157
GO:0042159
GO:0042632
GO:0042802
GO:0043226
GO:0043235
GO:0045177
GO:0046718
GO:0048844
GO:0048856
GO:0050729
GO:0050877
GO:0051246
GO:0051248
GO:0051649
GO:0060090
GO:0061771
GO:0061889
GO:0070508
GO:0071398
GO:0071404
GO:0071813
GO:0090118
GO:0090181
GO:0097242
GO:0097443
GO:0150094
GO:1903979
GO:1905167
GO:1905907
GO:1990666
HMNXSV003057635
Hs.213289.0.S1_3p_a_at
Hs.213289.1.S1_3p_a_at
ILMN_2053415
L00352_at
PH_hs_0012331
TC19000191.hg
g8051613_3p_a_at
Participates
as an output of
chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR (Homo sapiens)
LDLR:LDL complex => LDLR + LDL (Homo sapiens)
as a component of
chylomicron remnant:apoE:LDLR complex [endosome membrane] (Homo sapiens)
LDL:LDLR complex [endosome membrane] (Homo sapiens)
as an input of
LDLR [endosome membrane] => LDLR [plasma membrane] (Homo sapiens)
Other forms of this molecule
LDLR [endolysosome membrane]
LDLR [clathrin-coated endocytic vesicle membrane]
LDLR [plasma membrane]
Inferred To
LpR2 [endosome membrane]
(Drosophila melanogaster)
Homologues of LDLR [endosome membrane]
(Drosophila melanogaster)
gldi-2 [endosome membrane]
(Caenorhabditis elegans)
LpR1 [endosome membrane]
(Drosophila melanogaster)
ldlr [endosome membrane]
(Danio rerio)
ldlr [endosome membrane]
(Xenopus tropicalis)
Ldlr [endosome membrane]
(Mus musculus)
Ldlr [endosome membrane]
(Rattus norvegicus)
LDLR [endosome membrane]
(Bos taurus)
LDLR [endosome membrane]
(Canis familiaris)
LDLR [endosome membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001182728.1
,
NP_000518.1
,
NP_001182732.1
,
NP_001182729.1
,
NP_001182727.1
OpenTargets
ENSG00000130164
ZINC - Substances
LDLR_HUMAN
ZINC target
P01130
PRO
P01130
PDB
2LGP
,
5OYL
,
3P5C
,
2KRI
,
3P5B
,
1D2J
,
2MG9
,
2FCW
,
3SO6
,
1HJ7
,
5OY9
,
3GCX
,
1HZ8
,
2W2Q
,
1I0U
,
3GCW
,
1XFE
,
1F5Y
,
3BPS
,
2W2P
,
1LDR
,
2W2N
,
1F8Z
,
2W2M
,
1AJJ
,
1N7D
,
2W2O
,
1LDL
,
2M7P
,
4NE9
,
1IJQ
,
3M0C
GeneCards
P01130
HPA
ENSG00000130164-LDLR
Ensembl
ENST00000558518
,
ENSP00000440520
,
ENST00000558013
,
ENSP00000397829
,
ENSG00000130164
,
ENST00000535915
,
ENSP00000453346
,
ENST00000545707
,
ENSP00000454071
,
ENST00000455727
,
ENSP00000437639
Pharos - Targets
P01130
Orphanet
16347
ZINC - Predictions - Purchasable
LDLR_HUMAN
HMDB Protein
HMDBP02065
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NBP7-1 PCSK9
0.719
4
UniProt:P02649 APOE
10
APOE [early endosome]
(R-HSA-2429687)
APOE [endosome lumen]
(R-HSA-174804)
APOE [endosome membrane]
(R-HSA-174766)
APOE [clathrin-coated endocytic vesicle membrane]
(R-HSA-174651)
APOE [plasma membrane]
(R-HSA-174615)
APOE [endocytic vesicle lumen]
(R-HSA-3221641)
APOE [extracellular region]
(R-HSA-174646)
APOE-4 [extracellular region]
(R-HSA-9711070)
p-APOE [endoplasmic reticulum lumen]
(R-HSA-8956980)
APOE [endoplasmic reticulum lumen]
(R-HSA-6784908)
0.71
4
UniProt:Q8NBP7 PCSK9
5
PCSK9 [endolysosome membrane]
(R-HSA-6784823)
PCSK9 [lysosomal membrane]
(R-HSA-8855128)
PCSK9 [extracellular region]
(R-HSA-6784727)
p-PCSK9 [endoplasmic reticulum lumen]
(R-HSA-8956943)
PCSK9 [endoplasmic reticulum lumen]
(R-HSA-8956745)
0.676
10
UniProt:P30533 AMRP
0.667
3
UniProt:P02749 APOH
2
APOH [extracellular region]
(R-HSA-8848905)
APOH [platelet dense granule lumen]
(R-HSA-8848901)
0.618
3
UniProt:D3ZAR1
2
Ldlrap1 [clathrin-coated endocytic vesicle membrane]
(R-RNO-8869097)
Ldlrap1 [plasma membrane]
(R-RNO-171143)
0.558
3
UniProt:P04114 APOB
20
APOB(28-2179) [cytosol]
(R-HSA-2395786)
APOB(28-2179) [early endosome]
(R-HSA-2429651)
APOB(28-4563) [lysosomal lumen]
(R-HSA-8876369)
APOB(28-2179) [endosome lumen]
(R-HSA-174716)
APOB(28-2179) [endosome membrane]
(R-HSA-174762)
APOB(28-4563) [plasma membrane]
(R-HSA-171089)
APOB(28-4563) [clathrin-coated endocytic vesicle membrane]
(R-HSA-171155)
APOB(28-4563) [endosome lumen]
(R-HSA-171119)
APOB(28-4563) [endosome membrane]
(R-HSA-171121)
APOB(28-2179) [clathrin-coated endocytic vesicle membrane]
(R-HSA-174788)
APOB(28-2179) [plasma membrane]
(R-HSA-174625)
APOB(28-2179) [endoplasmic reticulum lumen]
(R-HSA-174620)
APOB(28-2179) [extracellular region]
(R-HSA-174770)
APOB(28-2179) [endoplasmic reticulum membrane]
(R-HSA-174637)
APOB(28-4563) [smooth endoplasmic reticulum]
(R-HSA-8866317)
APOB(28-4563) [endocytic vesicle lumen]
(R-HSA-2512789)
10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [endocytic vesicle lumen]
(R-HSA-2239461)
AcK-APOB(28-4563) [endocytic vesicle lumen]
(R-HSA-2239446)
AcK-APOB(28-4563) [extracellular region]
(R-HSA-2173751)
p-APOB(28-4563) [endoplasmic reticulum lumen]
(R-HSA-8957068)
0.558
4
UniProt:Q08117-2 TLE5
0.556
3
UniProt:Q9H2K0 MTIF3
1
MTIF3 [mitochondrial matrix]
(R-HSA-5368284)
0.556
3
UniProt:P0DTC2 S
20
S(686-815) [plasma membrane]
(R-COV-9770188)
Spike S2' Fragment [plasma membrane]
(R-COV-9770189)
S1 [plasma membrane]
(R-COV-9769950)
fully glycosylated Spike [plasma membrane]
(R-COV-9733472)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9766369)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9697006)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
(R-COV-9769952)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
0.537
4
UniProt:P17948 FLT1
1
VEGFR1 [plasma membrane]
(R-HSA-3004464)
0.463
2
UniProt:P04578 env
7
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
0.462
2
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