Reactome | PPIA [cytosol]

PPIA [cytosol]

Stable Identifier

R-HSA-173123

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CypA protein

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Signaling by the B Cell Receptor (BCR) (Homo sapiens)
    - Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
      - Calcineurin activates NFAT (Homo sapiens)
        
        Calcineurin dephosphorylates NFATC1,2,3 (Homo sapiens)
        
        Cyclophilin A:Cyclosporin A [cytosol] (Homo sapiens)
        
        PPIA [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62937 PPIA

Gene Names

PPIA, CYPA

Chain

chain:1-165, initiator methionine:, chain:2-165

Reference Genes

BioGPS Gene:5478 P629372

COSMIC (genes):PPIA PPIA

CTD Gene:5478 P629372

dbSNP Gene:5478 P629372

ENSEMBL:ENSG00000196262 PPIA

HGNC:9253 P629372

KEGG:hsa:5478 P629372

Monarch:5478 P629372

NCBI Gene:5478 P629372

OMIM:123840 P629372

UCSC:P62937 P629372

Reference Transcript

Participates

as a member of

as a component of

as an input of

Packaging of HIV virion on the host cell plasma membrane (Homo sapiens)

as an output of

Formation of Pre-Integration Complex (PIC) (Homo sapiens)

Other forms of this molecule

PPIA [ficolin-1-rich granule lumen]

PPIA [extracellular region]

PPIA [secretory granule lumen]

PPIA [extracellular exosome]

Cross References

Guide to Pharmacology - Targets

2751

ENSEMBL

ENSP00000503804, ENST00000678789, ENST00000489459, ENSP00000502945, ENST00000677107, ENSP00000419425, ENST00000355968, ENST00000678805, ENST00000468812, ENSP00000430817, ENSP00000427976, ENSG00000196262, ENSP00000504216, ENST00000677022, ENSP00000504735

OpenTargets

ENSG00000196262

ZINC - Substances

PPIA_HUMAN

ZINC target

P62937

PRO

P62937

GlyGen

P62937

PDB

7PCJ, 4N1Q, 6GJL, 5FJB, 1M9F, 6X4M, 5NOS, 1VBT, 6GJY, 5KV0, 8TBL, 6ZDJ, 8G9Q, 4YUH, 7N9X, 8TBI, 2MZU, 5KV1, 6Y9X, 7UXM, 1AWS, 5NOV, 2ALF, 1CWI, 1AWU, 3K0M, 3K0Q, 1CWL, 9BG1, 1CWO, 1M9D, 1OCA, 6U5D, 2X2D, 7TA8, 6X4Q, 5T9W, 6X4O, 4N1N, 2X2C, 1W8M, 6U5C, 5NOT, 9BFY, 6GS6, 1W8L, 4YUG, 4YUI, 5NOQ, 5KV5, 5NOR, 6GJI, 2X25, 8TBJ, 5KUW, 4N1O, 6X3Y, 8TBG, 2RMA, 7UPN, 5T9Z, 6GJJ, 1RMH, 1M9C, 3K0O, 1CWB, 1AK4, 5NOZ, 6Y9V, 1AWR, 1CWH, 1CWK, 3K0N, 3K0R, 3RDD, 1M63, 1CWM, 5TA4, 1ZKF, 5KUV, 3ODI, 4YUO, 7QBW, 8TBF, 1MIK, 5KUU, 2MS4, 5KUS, 4YUM, 6BTA, 5KUQ, 1M9E, 4N1R, 1VBS, 4YUK, 1M9X, 6U5G, 1W8V, 2RMB, 8G9P, 5KUZ, 5KUR, 7UXN, 1NMK, 2XGY, 7UXJ, 5WC7, 6Y9Y, 3CYH, 6Y9Z, 9AX6, 5NOW, 5LUD, 1CWF, 1AWT, 1CWJ, 5NOY, 1AWV, 7ABT, 1MF8, 6X4P, 8TBH, 5T9U, 5KV7, 5KUN, 5KV6, 1BCK, 3ODL, 6GJN, 5KV4, 5NOU, 8HZ8, 5F66, 6X4N, 4CYH, 4YUJ, 5KV2, 4N1S, 4N1M, 1M9Y, 6X3R, 6GJR, 5KUO, 8TBM, 5KV3, 4N1P, 2CYH, 8TBK, 6I42, 1CWA, 5NOX, 1CWC, 3CYS, 2CPL, 3K0P, 6Y9W, 1AWQ, 2N0T, 6U5E, 1FGL, 6GJP, 1YND, 4YUP, 5CYH, 8TBN, 5TA2, 4YUL, 5KUL, 4IPZ, 6GJM, 4YUN, 2X2A

HPA

ENSG00000196262-PPIA

GeneCards

PPIA

Pharos - Targets

P62937

ZINC - Predictions - Purchasable

PPIA_HUMAN

HMDB Protein

HMDBP10691

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.713	3
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.676	4
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.666	4
UniProt:Q72497 Q72497			0.623	7
UniProt:P46108-1 CRK			0.595	4
UniProt:Q99IB8-PRO_0000045602			0.59	2
UniProt:P35613 BSG	2	BSG [plasma membrane] (R-HSA-197673) BSG [Golgi membrane] (R-HSA-204478)	0.589	2
UniProt:O14686 KMT2D	1	KMT2D [nucleoplasm] (R-HSA-1183219)	0.558	2
UniProt:Q00535 CDK5	4	CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [nucleoplasm] (R-HSA-8863586)	0.556	3
UniProt:O75376 NCOR1	2	NCOR1 [nucleoplasm] (R-HSA-442501) NCOR1 [cytosol] (R-HSA-1253310)	0.556	3
UniProt:O43614 HCRTR2	1	HCRTR2 [plasma membrane] (R-HSA-389421)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:P62841 RPS15	2	RPS15 [cytosol] (R-HSA-72335) RPS15 [nucleoplasm] (R-HSA-6798706)	0.556	3
UniProt:O00429 DNM1L	2	DNM1L [cytosol] (R-HSA-351943) DNM1L [mitochondrial outer membrane] (R-HSA-351942)	0.527	5
UniProt:Q13618 CUL3	3	CUL3 [cytosol] (R-HSA-975979) CUL3 [nucleoplasm] (R-HSA-5635033) G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516)	0.527	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.508	2
UniProt:P0C6X7-PRO_0000037309 REP			0.508	4
UniProt:Q16849 PTPRN			0.508	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12
UniProt:O95831 AIFM1			0.463	2

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