Reactome | C1R N-terminal fragment [extracellular region]

C1R N-terminal fragment [extracellular region]

Stable Identifier

R-HSA-173606

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

C1R(18-446)

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Initial triggering of complement (Homo sapiens)
      - Conversion of C2 into C2a and C2b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        Activated C1R [extracellular region] (Homo sapiens)
        
        C1R N-terminal fragment [extracellular region] (Homo sapiens)
      - Conversion of C4 into C4a and C4b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        Activated C1R [extracellular region] (Homo sapiens)
        
        C1R N-terminal fragment [extracellular region] (Homo sapiens)
      - Creation of C4 and C2 activators (Homo sapiens)
        
        Classical antibody-mediated complement activation (Homo sapiens)
        
        Activation of C1r (Homo sapiens)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Homo sapiens)
        
        C1Q:2x Activated C1R:2xC1S [extracellular region] (Homo sapiens)
        
        2x Activated C1R:2xC1S [extracellular region] (Homo sapiens)
        
        Activated C1R [extracellular region] (Homo sapiens)
        
        C1R N-terminal fragment [extracellular region] (Homo sapiens)
        
        Activation of C1s (Homo sapiens)
        
        Activated C1R [extracellular region] (Homo sapiens)
        
        C1R N-terminal fragment [extracellular region] (Homo sapiens)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        Activated C1R [extracellular region] (Homo sapiens)
        
        C1R N-terminal fragment [extracellular region] (Homo sapiens)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Homo sapiens)
        
        C1Q:2x Activated C1R:2xC1S [extracellular region] (Homo sapiens)
        
        2x Activated C1R:2xC1S [extracellular region] (Homo sapiens)
        
        Activated C1R [extracellular region] (Homo sapiens)
        
        C1R N-terminal fragment [extracellular region] (Homo sapiens)
    - Regulation of Complement cascade (Homo sapiens)
      - Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Homo sapiens)
        
        Activated C1R:SERPING1 [extracellular region] (Homo sapiens)
        
        Activated C1R [extracellular region] (Homo sapiens)
        
        C1R N-terminal fragment [extracellular region] (Homo sapiens)
        
        Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Homo sapiens)
        
        2x Activated C1R:SERPING1:2x Activated C1S:SERPING1 [extracellular region] (Homo sapiens)
        
        Activated C1R:SERPING1 [extracellular region] (Homo sapiens)
        
        Activated C1R [extracellular region] (Homo sapiens)
        
        C1R N-terminal fragment [extracellular region] (Homo sapiens)
      - C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Homo sapiens)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        Activated C1R [extracellular region] (Homo sapiens)
        
        C1R N-terminal fragment [extracellular region] (Homo sapiens)
        
        Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Homo sapiens)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        Activated C1R [extracellular region] (Homo sapiens)
        
        C1R N-terminal fragment [extracellular region] (Homo sapiens)
      - C1-Inh binds and inactivates C1r, C1s (Homo sapiens)
        
        Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Homo sapiens)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        Activated C1R [extracellular region] (Homo sapiens)
        
        C1R N-terminal fragment [extracellular region] (Homo sapiens)
        
        Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Homo sapiens)
        
        2x Activated C1R:SERPING1:2x Activated C1S:SERPING1 [extracellular region] (Homo sapiens)
        
        Activated C1R:SERPING1 [extracellular region] (Homo sapiens)
        
        Activated C1R [extracellular region] (Homo sapiens)
        
        C1R N-terminal fragment [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P00736 C1R

Gene Names

C1R

Chain

signal peptide:1-17, chain:18-705, chain:18-463, chain:464-705

Reference Genes

BioGPS Gene:715 C1R

COSMIC (genes):C1R C1R

CTD Gene:715 C1R

dbSNP Gene:715 C1R

ENSEMBL:ENSG00000159403 C1R

HGNC:1246 C1R

KEGG:hsa:715 C1R

Monarch:715 C1R

NCBI Gene:715 C1R

OMIM:613785 C1R

UCSC:P00736 C1R

Reference Transcript

RefSeq:NM_001733.4 C1R

Participates

as a component of

Activated C1R [extracellular region] (Homo sapiens)

Other forms of this molecule

C1R(18-705) [extracellular region]

C1R C-terminal fragment [extracellular region]

Inferred To

C1R N-terminal fragment [extracellular region] (Bos taurus)

C1R N-terminal fragment [extracellular region] (Canis familiaris)

C1R N-terminal fragment [extracellular region] (Gallus gallus)

C1R N-terminal fragment [extracellular region] (Rattus norvegicus)

C1R N-terminal fragment [extracellular region] (Sus scrofa)

C1ra [extracellular region] (Mus musculus)

Cross References

RefSeq

NP_001724.3

ZINC - World Drugs

C1R_HUMAN

Guide to Pharmacology - Targets

2334

OpenTargets

ENSG00000159403

ZINC - Substances

C1R_HUMAN

ZINC target

P00736

PRO

P00736

Pharos - Targets

P00736

Orphanet

C1R

ZINC - Predictions - Purchasable

C1R_HUMAN

HMDB Protein

HMDBP07480

PDB

1MD7, 1MD8, 1APQ, 1GPZ, 2QY0, 6F39, 6F1H, 6F1D, 6F1C

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05155 SERPING1	20	SERPING1 [platelet alpha granule lumen] (R-HSA-139868) SERPING1 L177P [endoplasmic reticulum lumen] (R-HSA-9650574) SERPING1 R400C [endoplasmic reticulum lumen] (R-HSA-9650511) SERPING1 V288E [endoplasmic reticulum lumen] (R-HSA-9650415) SERPING1 G184_P228del [endoplasmic reticulum lumen] (R-HSA-9650472) SERPING1 F236S [endoplasmic reticulum lumen] (R-HSA-9650538) SERPING1 T189N [endoplasmic reticulum lumen] (R-HSA-9650346) SERPING1 P476L [endoplasmic reticulum lumen] (R-HSA-9650563) SERPING1 G184R [endoplasmic reticulum lumen] (R-HSA-9650424) SERPING1 P489R [endoplasmic reticulum lumen] (R-HSA-9650330) SERPING1 S170P [endoplasmic reticulum lumen] (R-HSA-9650362) SERPING1 S280_P282del [endoplasmic reticulum lumen] (R-HSA-9650522) SERPING1 V473M [endoplasmic reticulum lumen] (R-HSA-9650331) SERPING1 N291H [endoplasmic reticulum lumen] (R-HSA-9650545) SERPING1 Q484* [endoplasmic reticulum lumen] (R-HSA-9650410) SERPING1 A2_M53del [endoplasmic reticulum lumen] (R-HSA-9651435) SERPING1 W482* [endoplasmic reticulum lumen] (R-HSA-9650502) SERPING1 Q338* [endoplasmic reticulum lumen] (R-HSA-9651424) SERPING1 I196N [endoplasmic reticulum lumen] (R-HSA-9651390) SERPING1 S36Ffs*21 [endoplasmic reticulum lumen] (R-HSA-9651423)	0.544	2
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.527	3