Properdin stabilizes C3b:Bb bound to cell surfaces

Stable Identifier
R-HSA-173754
Type
Reaction [binding]
Species
Homo sapiens
Compartment
external side of plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Properdin stabilizes C3b:Bb bound to cell surfaces
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
C3b:Bb is naturally labile with a half-life of ~90 s; association of the complex with properdin extends the half-life to ~30 min. (Medicus et al. 1976). Properdin is found in the blood as a mixture of multivalent oligomers: 30% dimers, 45% trimers, 10% tetramers, and 15% higher oligomers. Monomers associate with one another in a head-to-tail arrangement, producing closed circular structures (Smith et al. 1984; Alcorlo M et al. 2013). These features suggest that the properdin oligomer associated with a C3b:Bb complex on a surface such as a cell membrane can facilitate recruitment of additional C3b:Bb complexes to the site (Farries et al. 1988; Hourcade 2006).
Literature References
Participants
Input
Output
Participates
as an event of
Orthologous Events
Properdin stabilizes C3b:Bb bound to cell surfaces (Bos taurus)
Properdin stabilizes C3b:Bb bound to cell surfaces (Canis familiaris)
Properdin stabilizes C3b:Bb bound to cell surfaces (Mus musculus)
Properdin stabilizes C3b:Bb bound to cell surfaces (Sus scrofa)
Properdin stabilizes C3b:Bb bound to cell surfaces (Xenopus tropicalis)
Authored
de Bono, B  (2004-08-04)
Reviewed
D'Eustachio, P  (2006-07-04)
Created
de Bono, B  (2006-02-16)
Cite Us!