Reactome | Formation of RTC (Reverse Transcription Complex)

Formation of RTC (Reverse Transcription Complex)

Stable Identifier

R-HSA-173771

Type

Reaction [dissociation]

Species

Homo sapiens

Related Species

Human immunodeficiency virus 1

Compartment

cytosol

ReviewStatus

5/5

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Early Phase of HIV Life Cycle (Homo sapiens)
        
        Formation of RTC (Reverse Transcription Complex) (Homo sapiens)

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Formation of RTC (Reverse Transcription Complex)

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Reverse transcription complex is a transitory structure where reverse transcription takes place. Initially, it is likely identical to the RNA-protein complex found inside the virion core. Upon maturation, it may shed some HIV proteins (such as MA or Vpr) and incorporate cellular proteins (such as INI1 or PML).

Literature References

PubMed ID	Title	Journal	Year
16409631	Intracytoplasmic maturation of the human immunodeficiency virus type 1 reverse transcription complexes determines their capacity to integrate into chromatin Iordanskiy, S, Berro, R, Altieri, M, Kashanchi, F, Bukrinsky, M	Retrovirology	2006
10881997	Morphologic changes in human immunodeficiency virus type 1 virions secondary to intravirion reverse transcription: evidence indicating that reverse transcription may not take place within the intact viral core Zhang, H, Dornadula, G, Orenstein, J, Pomerantz, RJ	J Hum Virol	2000
7687060	Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection Bukrinsky, M, Sharova, N, McDonald, TL, Pushkarskaya, T, Tarpley, WG, Stevenson, M	Proc Natl Acad Sci U S A	1993
11264352	Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1 Fassati, A, Goff, SP	J Virol	2001

Participants

Input

uncoated viral complex [cytosol] (Homo sapiens)

Output

Participates

as an event of

Early Phase of HIV Life Cycle (Homo sapiens)

Event Information

Go Biological Process

uncoating of virus (0019061)

Disease

Name	Identifier	Synonyms
Human immunodeficiency virus infectious disease	DOID:526	HIV infection

Cross References

Mondo

0005109

Authored

Iordanskiy, S (2006-04-03)

Bukrinsky, M (2006-04-03)

Reviewed

Aiken, C (2006-10-31)

Created

Gopinathrao, G (2006-02-17)

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