APC/C:Cdc20 mediated degradation of Cyclin B

Stable Identifier
R-HSA-174048
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Pathway
Species
Homo sapiens
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The degradation of cyclin B1, which appears to occur at the mitotic spindle, is delayed until the metaphase /anaphase transition by the spindle assembly checkpoint and is required in order for sister chromatids to separate (Geley et al. 2001;Hagting et al, 2002).

Literature References
PubMed ID Title Journal Year
11285280 Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint

Geley, S, Kramer, E, Gieffers, C, Gannon, J, Peters, JM, Hunt, T

J Cell Biol 2001
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Orthologous Events
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