APC/C:Cdc20 mediated degradation of Cyclin B

Stable Identifier
R-HSA-174048
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
APC/C:Cdc20 mediated degradation of Cyclin B
Click the image above or here to open this pathway in the Pathway Browser

The degradation of cyclin B1, which appears to occur at the mitotic spindle, is delayed until the metaphase /anaphase transition by the spindle assembly checkpoint and is required in order for sister chromatids to separate (Geley et al. 2001;Hagting et al, 2002).

Literature References
PubMed ID Title Journal Year
11285280 Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint

Geley, S, Kramer, E, Gieffers, C, Gannon, J, Peters, JM, Hunt, T

J Cell Biol 2001
Participants
Events
Participant Of
hasEvent
Event Information
Go Biological Process
anaphase-promoting complex-dependent catabolic process (0031145)
Orthologous Events
APC/C:Cdc20 mediated degradation of Cyclin B (Canis familiaris)
APC/C:Cdc20 mediated degradation of Cyclin B (Danio rerio)
APC/C:Cdc20 mediated degradation of Cyclin B (Dictyostelium discoideum)
APC/C:Cdc20 mediated degradation of Cyclin B (Drosophila melanogaster)
APC/C:Cdc20 mediated degradation of Cyclin B (Gallus gallus)
APC/C:Cdc20 mediated degradation of Cyclin B (Mus musculus)
APC/C:Cdc20 mediated degradation of Cyclin B (Rattus norvegicus)
APC/C:Cdc20 mediated degradation of Cyclin B (Sus scrofa)
APC/C:Cdc20 mediated degradation of Cyclin B (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Lorca, T  (2006-01-26)
Castro, A  (2006-01-26)
Reviewed
Peters, JM  (2006-03-28)
Created
Matthews, L  (2006-02-17)
Cite Us!