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CDC16 [nucleoplasm]
Stable Identifier
R-HSA-174049
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Apc6/Cdc16
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1 polyubiquitinates SKP2 (Homo sapiens)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
RB1 recruits APC/C:Cdh1 complex to SKP2 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
Phosphorylation of the APC/C (Homo sapiens)
Free APC/C phosphorylated by Cyclin B:Cdc2 (Homo sapiens)
anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Free APC/C phosphorylated by Plk1 (Homo sapiens)
anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Multiubiquitination of APC/C-associated Cdh1 (Homo sapiens)
multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
Association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Dissociation of phospho-Cdh1 from the APC/C complex (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Cdh1:APC/C complex binds EHMT1:EHMT2 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Homo sapiens)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Stimulation of IL8 transcription in senescent cells (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of mitotic cell cycle (Homo sapiens)
Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by VENTX (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC16 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13042 CDC16
Gene Names
CDC16, ANAPC6
Chain
chain:1-620
Reference Genes
BioGPS Gene:8881 CDC16
COSMIC (genes):CDC16 CDC16
CTD Gene:8881 CDC16
dbSNP Gene:8881 CDC16
ENSEMBL:ENSG00000130177 CDC16
HGNC:1720 CDC16
KEGG:hsa:8881 CDC16
Monarch:8881 CDC16
NCBI Gene:8881 CDC16
OMIM:603461 CDC16
UCSC:Q13042 CDC16
Reference Transcript
RefSeq:NM_003903.4 CDC16
RefSeq:NM_001078645.2 CDC16
RefSeq:NM_001330104.1 CDC16
RefSeq:NM_001318517.2 CDC16
RefSeq:NM_001330101.1 CDC16
RefSeq:NM_001318518.2 CDC16
RefSeq:NM_001330105.1 CDC16
RefSeq:XM_017020833.1 CDC16
Other Identifiers
11716809_a_at
11719625_a_at
11746106_a_at
11746107_a_at
11754804_x_at
11760270_at
16776989
202717_PM_s_at
202717_s_at
209658_PM_at
209658_at
209659_PM_s_at
209659_s_at
3503165
3503166
3503167
3503168
3503173
3503175
3503176
3503177
3503178
3503179
3503180
3503181
3503182
3503183
3503184
3503185
3503186
3503187
3503188
3503189
3503190
3503193
3503195
3503197
3503199
3503200
3503201
3503202
3503203
3503204
3503205
3503206
3503207
3503208
3503209
3503210
3503211
40404_s_at
7970347
8881
A_14_P115284
A_23_P88083
A_33_P3392325
GE58978
GO:0005515
GO:0005634
GO:0005654
GO:0005680
GO:0005737
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0007346
GO:0016567
GO:0030163
GO:0031145
GO:0043226
GO:0045842
GO:0051301
GO:0051445
GO:0070936
GO:0070979
GO:0072686
GO:0141198
HMNXSV003003296
HMNXSV003007455
HMNXSV003010194
ILMN_1727389
ILMN_2256765
ILMN_2339796
PH_hs_0000215
TC13000435.hg
U18291_at
g4502700_3p_a_at
Participates
as a component of
anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
CDC16 [cytosol]
Inferred To
cdc16 [nucleoplasm]
(Xenopus tropicalis)
Cdc16 [nucleoplasm]
(Drosophila melanogaster)
Cdc16 [nucleoplasm]
(Mus musculus)
Cdc16 [nucleoplasm]
(Rattus norvegicus)
anapc6 [nucleoplasm]
(Dictyostelium discoideum)
CDC16 [nucleoplasm]
(Bos taurus)
CDC16 [nucleoplasm]
(Canis familiaris)
CDC16 [nucleoplasm]
(Gallus gallus)
CDC16 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001305447.1
,
NP_001305446.1
,
NP_001317034.1
,
NP_001317030.1
,
NP_001317033.1
,
NP_003894.3
,
XP_016876322.1
,
NP_001072113.1
OpenTargets
ENSG00000130177
ENSEMBL
ENST00000375308
,
ENST00000356221
,
ENST00000375310
,
ENSP00000353549
,
ENSP00000364459
,
ENST00000252457
,
ENST00000360383
,
ENSP00000348554
,
ENSP00000364457
,
ENSP00000252457
HPA
ENSG00000130177-CDC16
PRO
Q13042
Pharos - Targets
Q13042
PDB
5G05
,
5G04
,
8PKP
,
6TNT
,
5L9U
,
5L9T
,
6Q6H
,
7QE7
,
8TAR
,
6TM5
,
6Q6G
,
6TLJ
,
8S4G
,
5KHR
,
8TAU
,
5KHU
,
4UI9
,
5LCW
,
5A31
,
3HYM
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60566 BUB1B
1
BUB1B [cytosol]
(R-HSA-141436)
0.788
5
UniProt:Q12834 CDC20
3
CDC20 [cytosol]
(R-HSA-141412)
CDC20 [nucleoplasm]
(R-HSA-174112)
PolyUb-CDC20 [nucleoplasm]
(R-HSA-6783069)
0.708
5
UniProt:Q9UM11 FZR1
4
FZR1 [cytosol]
(R-HSA-174249)
FZR1 [nucleoplasm]
(R-HSA-174099)
p-FZR1 [nucleoplasm]
(R-HSA-174257)
p-FZR1 [cytosol]
(R-HSA-174193)
0.643
5
UniProt:P51955 NEK2
1
NEK2 [cytosol]
(R-HSA-177329)
0.643
3
UniProt:Q9UKT4 FBXO5
6
p-S182-FBXO5 [cytosol]
(R-HSA-177324)
p-S145,S149-FBXO5 [cytosol]
(R-HSA-174207)
FBXO5 [nucleoplasm]
(R-HSA-174060)
p-S182-FBXO5 [nucleoplasm]
(R-HSA-176447)
p-S145,S149-FBXO5 [nucleoplasm]
(R-HSA-174220)
p-FBXO5 [nucleoplasm]
(R-HSA-163049)
0.643
3
UniProt:Q9JJ66
3
Cdc20 [nucleoplasm]
(R-MMU-6783069)
Cdc20 [nucleoplasm]
(R-MMU-174112)
Cdc20 [cytosol]
(R-MMU-141412)
0.564
2
UniProt:Q13257 MAD2L1
2
Activated MAD2L1 [cytosol]
(R-HSA-141447)
MAD2L1 [cytosol]
(R-HSA-141400)
0.527
3
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