Degradation of multiubiquitinated Cdh1

Stable Identifier
R-HSA-174058
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
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Degradation of multiubiquitinated Cdh1
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At the beginning of this reaction, 1 molecule of 'multiubiquitinated Cdh1 associated with APC/C' is present. At the end of this reaction, 1 molecule of 'phosphorylated anaphase promoting complex (APC/C)', and 3 molecules of 'ubiquitin' are present.

This reaction takes place in the 'nucleoplasm' and is mediated by the 'endopeptidase activity' of '26S proteasome'.

Literature References
PubMed ID Title Journal Year
15029244 Mammalian Cdh1/Fzr mediates its own degradation

Listovsky, T, Oren, YS, Yudkovsky, Y, Mahbubani, HM, Weiss, AM, Lebendiker, M, Brandeis, M

EMBO J 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [nucleoplasm]
Physical Entity
26S proteasome [nucleoplasm]
Activity
endopeptidase activity (0004175)
Orthologous Events
Degradation of multiubiquitinated Cdh1 (Bos taurus)
Degradation of multiubiquitinated Cdh1 (Canis familiaris)
Degradation of multiubiquitinated Cdh1 (Danio rerio)
Degradation of multiubiquitinated Cdh1 (Dictyostelium discoideum)
Degradation of multiubiquitinated Cdh1 (Drosophila melanogaster)
Degradation of multiubiquitinated Cdh1 (Mus musculus)
Degradation of multiubiquitinated Cdh1 (Rattus norvegicus)
Degradation of multiubiquitinated Cdh1 (Sus scrofa)
Degradation of multiubiquitinated Cdh1 (Xenopus tropicalis)
Authored
Matthews, L  (2006-01-30)
Reviewed
Peters, JM  (2006-03-28)
Created
Matthews, L  (2006-02-17)