Degradation of multiubiquitinated Cdh1

Stable Identifier
R-HSA-174058
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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At the beginning of this reaction, 1 molecule of 'multiubiquitinated Cdh1 associated with APC/C' is present. At the end of this reaction, 1 molecule of 'phosphorylated anaphase promoting complex (APC/C)', and 3 molecules of 'ubiquitin' are present.

This reaction takes place in the 'nucleoplasm' and is mediated by the 'endopeptidase activity' of '26S proteasome'.

Literature References
PubMed ID Title Journal Year
15029244 Mammalian Cdh1/Fzr mediates its own degradation

Listovsky, T, Oren, YS, Yudkovsky, Y, Mahbubani, HM, Weiss, AM, Lebendiker, M, Brandeis, M

EMBO J 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created