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UBE2E1 [nucleoplasm]
Stable Identifier
R-HSA-174063
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
E1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1 polyubiquitinates SKP2 (Homo sapiens)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
RB1 recruits APC/C:Cdh1 complex to SKP2 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
Phosphorylation of the APC/C (Homo sapiens)
Free APC/C phosphorylated by Cyclin B:Cdc2 (Homo sapiens)
anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Free APC/C phosphorylated by Plk1 (Homo sapiens)
anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Multiubiquitination of APC/C-associated Cdh1 (Homo sapiens)
multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
Association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Dissociation of phospho-Cdh1 from the APC/C complex (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Cdh1:APC/C complex binds EHMT1:EHMT2 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Homo sapiens)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Stimulation of IL8 transcription in senescent cells (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of mitotic cell cycle (Homo sapiens)
Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by VENTX (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
UBE2E1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51965 UBE2E1
Gene Names
UBE2E1, UBCH6
Chain
initiator methionine:1, chain:2-193
Reference Genes
BioGPS Gene:7324 UBE2E1
COSMIC (genes):UBE2E1 UBE2E1
CTD Gene:7324 UBE2E1
dbSNP Gene:7324 UBE2E1
ENSEMBL:ENSG00000170142 UBE2E1
HGNC:12477 UBE2E1
KEGG Gene (Homo sapiens):7324 UBE2E1
Monarch:7324 UBE2E1
NCBI Gene:7324 UBE2E1
OMIM:602916 UBE2E1
UCSC:P51965 UBE2E1
Reference Transcript
RefSeq:NM_001202476.1 UBE2E1
RefSeq:NM_003341.4 UBE2E1
RefSeq:NM_182666.2 UBE2E1
Other Identifiers
0002570368
11757878_s_at
212519_at
2614062
2614063
2614064
2614066
2614067
2614071
2614073
2614100
2614101
2614103
2614104
2614105
2614106
37358_at
7324
8078262
A_14_P125715
A_23_P6963
GE60159
GO:0000151
GO:0000166
GO:0000209
GO:0000278
GO:0003674
GO:0004842
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006511
GO:0007049
GO:0008150
GO:0009056
GO:0010390
GO:0016567
GO:0016740
GO:0018215
GO:0031145
GO:0032020
GO:0032991
GO:0033523
GO:0042296
GO:0043167
GO:0043226
GO:0051276
GO:0061631
GO:0070936
GO:1901990
HMNXSV003041722
HMNXSV003056849
Hs.7766.0.A2_3p_at
ILMN_1806778
ILMN_2371685
PH_hs_0009892
TC03000125.hg
Participates
as a component of
anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
Ub-C131-UBE2E1 [nucleoplasm]
UBE2E1 [nucleoplasm]
Ub-C131-UBE2E1 [cytosol]
UBE2E1 [cytosol]
Inferred To
Ghost homologue of UBE2E1 [nucleoplasm]
(Danio rerio)
UBE2E1 [nucleoplasm]
(Canis familiaris)
UBE2E1 [nucleoplasm]
(Dictyostelium discoideum)
UBE2E1 [nucleoplasm]
(Gallus gallus)
UBE2E1 [nucleoplasm]
(Sus scrofa)
Ube2e1 [nucleoplasm]
(Mus musculus)
Ube2e1 [nucleoplasm]
(Rattus norvegicus)
Ubc2 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_003332.1
,
NP_872607.1
,
NP_001189405.1
OpenTargets
ENSG00000170142
HPA
ENSG00000170142-UBE2E1
GeneCards
P51965
Ensembl
ENSP00000329113
,
ENSG00000170142
,
ENSP00000303709
,
ENST00000424381
,
ENST00000346855
,
ENSP00000411351
,
ENST00000306627
PRO
P51965
HMDB Protein
HMDBP00620
PDB
5LBN
,
3BZH
,
6FGA
,
1XR9
,
4JJQ
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6ZNA4 RNF111
2
RNF111 [cytosol]
(R-HSA-975981)
RNF111 [nucleoplasm]
(R-HSA-2186765)
0.553
2
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