Phosphorylation of Cdh1 by Cyclin A:Cdk2

Stable Identifier
R-HSA-174079
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the G1/S transition, the Cdh1 subunit of the APC:Cdh1 complex is phosphorylated by Cyclin A:Cdk2 and dissociates from APC/C. This inactivates APC/C and permits the accumulation of cell cycle proteins required for DNA synthesis and entry into mitosis.

Literature References
PubMed ID Title Journal Year
10548110 Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex

Lukas, C, Sorensen, CS, Kramer, E, Santoni-Rugiu, E, Lindeneg, C, Peters, JM, Lukas, J

Nature 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created