Degradation of multiubiquitinated cell cycle proteins

Stable Identifier
R-HSA-174105
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
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Degradation of multiubiquitinated cell cycle proteins
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Cell cycle proteins mulitubiquitinated by the APC/C are targeted for degradation by the 26S proteasome.

Literature References
PubMed ID Title Journal Year
16413484 The processivity of multiubiquitination by the APC determines the order of substrate degradation

Rape, M, Reddy, SK, Kirschner, MW

Cell 2006
15678131 The anaphase-promoting complex: a key factor in the regulation of cell cycle

Castro, A, Bernis, C, Vigneron, S, Labbe, JC, Lorca, T

Oncogene 2005
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
26S proteasome [cytosol]
Activity
endopeptidase activity (0004175)
Orthologous Events
Degradation of multiubiquitinated cell cycle proteins (Bos taurus)
Degradation of multiubiquitinated cell cycle proteins (Canis familiaris)
Degradation of multiubiquitinated cell cycle proteins (Danio rerio)
Degradation of multiubiquitinated cell cycle proteins (Dictyostelium discoideum)
Degradation of multiubiquitinated cell cycle proteins (Drosophila melanogaster)
Degradation of multiubiquitinated cell cycle proteins (Mus musculus)
Degradation of multiubiquitinated cell cycle proteins (Rattus norvegicus)
Degradation of multiubiquitinated cell cycle proteins (Sus scrofa)
Degradation of multiubiquitinated cell cycle proteins (Xenopus tropicalis)
Authored
Lorca, T  (2006-01-26)
Castro, A  (2006-01-26)
Reviewed
Peters, JM  (2006-03-28)
Created
Matthews, L  (2006-02-17)
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