Degradation of multiubiquitinated cell cycle proteins

Stable Identifier
R-HSA-174105
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Degradation of multiubiquitinated cell cycle proteins
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Cell cycle proteins mulitubiquitinated by the APC/C are targeted for degradation by the 26S proteasome.
Literature References
PubMed ID Title Journal Year
15678131 The anaphase-promoting complex: a key factor in the regulation of cell cycle

Lorca, T, Bernis, C, Vigneron, S, Castro, A, Labbe, JC

Oncogene 2005
16413484 The processivity of multiubiquitination by the APC determines the order of substrate degradation

Kirschner, MW, Rape, M, Reddy, SK

Cell 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Degradation of multiubiquitinated cell cycle proteins (Bos taurus)
Degradation of multiubiquitinated cell cycle proteins (Canis familiaris)
Degradation of multiubiquitinated cell cycle proteins (Dictyostelium discoideum)
Degradation of multiubiquitinated cell cycle proteins (Drosophila melanogaster)
Degradation of multiubiquitinated cell cycle proteins (Mus musculus)
Degradation of multiubiquitinated cell cycle proteins (Rattus norvegicus)
Degradation of multiubiquitinated cell cycle proteins (Sus scrofa)
Authored
Castro, A  (2006-01-26)
Lorca, T  (2006-01-26)
Reviewed
Peters, JM  (2006-03-28)
Created
Matthews, L  (2006-02-17)
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