Reactome | CDC20 [nucleoplasm]

CDC20 [nucleoplasm]

Stable Identifier

R-HSA-174112

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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Locations in the PathwayBrowser for interactor UniProt:P24941

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
        
        Association of Emi1 with Cdc20 (Homo sapiens)
        
        CDC20 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q12834 CDC20

Gene Names

CDC20

Chain

chain:1-499

Reference Genes

BioGPS Gene:991 CDC20

COSMIC (genes):CDC20 CDC20

CTD Gene:991 CDC20

dbSNP Gene:991 CDC20

ENSEMBL:ENSG00000117399 CDC20

HGNC:1723 CDC20

KEGG Gene (Homo sapiens):991 CDC20

Monarch:991 CDC20

NCBI Gene:991 CDC20

OMIM:603618 CDC20

UCSC:Q12834 CDC20

Reference Transcript

RefSeq:NM_001255.2 CDC20

Other Identifiers

0003610079

11717163_s_at

11748314_a_at

16663514

202870_s_at

2333137

2333138

2333139

2333140

2333142

2333144

2333147

2333148

2333149

2333150

2333151

2333152

2333155

2333156

2333158

2333159

2333160

3177818

3177820

38414_at

7900699

991

A_23_P149200

GE58880

GO:0000003

GO:0000278

GO:0000922

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005680

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0006464

GO:0006511

GO:0007010

GO:0007049

GO:0007059

GO:0007064

GO:0007094

GO:0007267

GO:0007399

GO:0008022

GO:0008150

GO:0008283

GO:0008284

GO:0009056

GO:0010997

GO:0016567

GO:0016579

GO:0019899

GO:0021700

GO:0022607

GO:0030154

GO:0030234

GO:0031145

GO:0031915

GO:0032991

GO:0034330

GO:0040020

GO:0042826

GO:0043226

GO:0048471

GO:0048856

GO:0050773

GO:0051276

GO:0051301

GO:0090129

GO:0090307

GO:0097027

GO:0140014

GO:1901990

GO:1904668

GO:1905786

GO:1990757

HMNXSV003046343

ILMN_1663390

TC01000545.hg

U05340_at

g4557436_3p_s_at

Participates

as a component of

as an input of

Association of Emi1 with Cdc20 (Homo sapiens)

as a member of

Cdc20/Cdh1 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

CDC20 [cytosol]

PolyUb-CDC20 [nucleoplasm]

Inferred To

CDC20 [nucleoplasm] (Bos taurus)

CDC20 [nucleoplasm] (Canis familiaris)

CDC20 [nucleoplasm] (Gallus gallus)

CDC20 [nucleoplasm] (Saccharomyces cerevisiae)

CDC20 [nucleoplasm] (Sus scrofa)

fzy [nucleoplasm] (Drosophila melanogaster)

slp1 [nucleoplasm] (Schizosaccharomyces pombe)

fzy-1 [nucleoplasm] (Caenorhabditis elegans)

Cdc20 [nucleoplasm] (Mus musculus)

Cdc20 [nucleoplasm] (Rattus norvegicus)

cdc20 [nucleoplasm] (Danio rerio)

cdc20 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001246.2

OpenTargets

ENSG00000117399

HPA

ENSG00000117399-CDC20

GeneCards

Q12834

Ensembl

ENST00000372462, ENSP00000361540, ENST00000310955, ENSP00000308450, ENSG00000117399

PRO

Q12834

PDB

4N14, 6F0X, 6Q6H, 4GGA, 5KHR, 6Q6G, 5G04, 4GGD, 4GGC, 5LCW, 5KHU

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13257 MAD2L1	2	Activated MAD2L1 [cytosol] (R-HSA-141447) MAD2L1 [cytosol] (R-HSA-141400)	0.98	34
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.972	32
UniProt:P30260 CDC27	2	CDC27 [nucleoplasm] (R-HSA-174175) CDC27 [cytosol] (R-HSA-174073)	0.932	12
UniProt:Q9UJX5 ANAPC4	2	ANAPC4 [cytosol] (R-HSA-174168) ANAPC4 [nucleoplasm] (R-HSA-174115)	0.737	9
UniProt:Q13042 CDC16	2	CDC16 [cytosol] (R-HSA-174156) CDC16 [nucleoplasm] (R-HSA-174049)	0.623	4
UniProt:Q9UM13 ANAPC10	2	ANAPC10 [cytosol] (R-HSA-174142) ANAPC10 [nucleoplasm] (R-HSA-174047)	0.621	7
UniProt:Q9Y2Z4 YARS2	1	YARS2 [mitochondrial matrix] (R-HSA-379634)	0.564	2
UniProt:Q9Z1S0	1	Bub1b [cytosol] (R-MMU-141436)	0.564	2
UniProt:Q9CPV2	2	Anapc16 [cytosol] (R-MMU-6805138) Anapc16 [nucleoplasm] (R-MMU-6805137)	0.564	3
UniProt:Q8BGZ4	2	Cdc23 [cytosol] (R-MMU-174137) Cdc23 [nucleoplasm] (R-MMU-174228)	0.564	4
UniProt:Q99JP4	2	Cdc26 [cytosol] (R-MMU-174052) Cdc26 [nucleoplasm] (R-MMU-174216)	0.564	3
UniProt:Q9Z1B5	1	Mad2l1 [cytosol] (R-MMU-141400)	0.564	2
UniProt:Q8R349	2	Cdc16 [cytosol] (R-MMU-174156) Cdc16 [nucleoplasm] (R-MMU-174049)	0.564	3
UniProt:Q8IXJ6-2 SIRT2			0.544	2
UniProt:Q9UJX6 ANAPC2	2	ANAPC2 [cytosol] (R-HSA-174229) ANAPC2 [nucleoplasm] (R-HSA-174141)	0.528	2
UniProt:Q9UJX2 CDC23	2	CDC23 [nucleoplasm] (R-HSA-174228) CDC23 [cytosol] (R-HSA-174137)	0.527	3
UniProt:Q96DE5 ANAPC16	2	ANAPC16 [cytosol] (R-HSA-6805138) ANAPC16 [nucleoplasm] (R-HSA-6805137)	0.527	3
UniProt:O43683 BUB1	1	BUB1 [cytosol] (R-HSA-377888)	0.527	2
UniProt:P20248 CCNA2	3	CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [nucleoplasm] (R-HSA-68905)	0.527	2
UniProt:P24941 CDK2	5	CDK2 [cytosol] (R-HSA-157440) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.527	2
UniProt:Q9UI95 MAD2L2	1	MAD2L2 [nucleoplasm] (R-HSA-59092)	0.524	2
UniProt:Q8VDQ8	1	Sirt2 [cytosol] (R-MMU-2161118)	0.499	3
UniProt:Q15645-1 TRIP13			0.488	4
UniProt:Q15013-1 MAD2L1BP			0.488	12
UniProt:Q13257-1 MAD2L1			0.488	14

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