SCF-beta-TrCP mediated degradation of Emi1

Stable Identifier
R-HSA-174113
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Pathway
Species
Homo sapiens
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Emi1 destruction in early mitosis requires the SCF beta-TrCP ubiquitin ligase complex. Binding of beta-TrCP to Emi1 occurs in late prophase and requires phosphorylation at the DSGxxS consensus motif as well as Cdk mediated phosphorylation. A two-step mechanism has been proposed in which the phosphorylation of Emi1 by Cdc2 occurs after the G2-M transition followed soon after by binding of beta-TrCP to the DSGxxS phosphorylation sites. Emi1 is then poly-ubiquitinated and degraded by the 26S proteasome.

Literature References
PubMed ID Title Journal Year
12791267 Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

Margottin-Goguet, F, Hsu, JY, Loktev, A, Hsieh, HM, Reimann, JD, Jackson, PK

Dev Cell 2003
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Orthologous Events
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BioModels Database
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