Reactome | ANAPC4 [nucleoplasm]

ANAPC4 [nucleoplasm]

Stable Identifier

R-HSA-174115

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Apc4

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
      - Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        ANAPC4 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by VENTX (Homo sapiens)
      - Regulation of IL6 transcription (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        ANAPC4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UJX5 ANAPC4

Gene Names

ANAPC4, APC4

Chain

chain:1-808

Reference Genes

BioGPS Gene:29945 ANAPC4

COSMIC (genes):ANAPC4 ANAPC4

CTD Gene:29945 ANAPC4

dbSNP Gene:29945 ANAPC4

ENSEMBL:ENSG00000053900 ANAPC4

HGNC:19990 ANAPC4

KEGG Gene (Homo sapiens):29945 ANAPC4

Monarch:29945 ANAPC4

NCBI Gene:29945 ANAPC4

OMIM:606947 ANAPC4

UCSC:Q9UJX5 ANAPC4

Reference Transcript

Other Identifiers

0006510064

11720137_a_at

16965559

226917_s_at

232524_x_at

2721849

2721851

2721852

2721853

2721854

2721855

2721856

2721858

2721860

2721861

2721864

2721867

2721868

2721869

2721870

2721871

2721873

2721875

2721876

2721877

2721878

2721879

2721882

2721885

2721887

2721888

2721889

2721891

2721895

2721897

2721899

2721900

29945

44071_at

8094408

A_14_P201349

A_23_P317800

GE80321

GO:0000278

GO:0003674

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005680

GO:0005737

GO:0005829

GO:0006464

GO:0006511

GO:0007049

GO:0007059

GO:0008150

GO:0009056

GO:0016567

GO:0019899

GO:0019903

GO:0030071

GO:0031145

GO:0032991

GO:0034399

GO:0043226

GO:0045842

GO:0051276

GO:0051301

GO:0070979

GO:0140014

GO:1901990

Hs.273391.0.S1_3p_s_at

Hs.306420.0.S1_3p_s_at

ILMN_1802973

PH_hs_0025519

TC04000176.hg

Participant Of

hasComponent

Other forms of this molecule

ANAPC4 [cytosol]

Inferred To

anapc4 [nucleoplasm] (Danio rerio)

anapc4 [nucleoplasm] (Dictyostelium discoideum)

ANAPC4 [nucleoplasm] (Canis familiaris)

ANAPC4 [nucleoplasm] (Gallus gallus)

ANAPC4 [nucleoplasm] (Sus scrofa)

ANAPC4 [nucleoplasm] (Xenopus tropicalis)

Anapc4 [nucleoplasm] (Mus musculus)

Anapc4 [nucleoplasm] (Rattus norvegicus)

APC4 [nucleoplasm] (Drosophila melanogaster)

Homologues of ANAPC4 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_037499.2, NP_001273685.1

OpenTargets

ENSG00000053900

GeneCards

Q9UJX5

HPA

ENSG00000053900-ANAPC4

Ensembl

ENSP00000318775, ENSG00000053900, ENSP00000426654, ENST00000315368, ENST00000510092

PRO

Q9UJX5

PDB

5G05, 4UI9, 5LCW, 6TLJ, 5BPW, 6Q6H, 5A31, 5L9T, 5KHU, 6Q6G, 5G04, 5L9U, 5KHR, 6TM5

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12834 CDC20	3	CDC20 [nucleoplasm] (R-HSA-174112) CDC20 [cytosol] (R-HSA-141412) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.737	9
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.708	10
UniProt:Q13257 MAD2L1	2	Activated MAD2L1 [cytosol] (R-HSA-141447) MAD2L1 [cytosol] (R-HSA-141400)	0.527	5
UniProt:P51955 NEK2	1	NEK2 [cytosol] (R-HSA-177329)	0.499	6
UniProt:Q8NI77 KIF18A	1	KIF18A [cytosol] (R-HSA-376239)	0.499	2
UniProt:P60484 PTEN	122	PTEN [nucleoplasm] (R-HSA-5690148) K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379) PTEN C124Y [cytosol] (R-HSA-2317464) PTEN R130P [cytosol] (R-HSA-2317432) PTEN C124F [cytosol] (R-HSA-2317461) PTEN G129V [cytosol] (R-HSA-2318503) PTEN S170I [cytosol] (R-HSA-2318455) PTEN S170G [cytosol] (R-HSA-2318465) PTEN E99* [cytosol] (R-HSA-9659052) PTEN G165* [cytosol] (R-HSA-9659117) PTEN E157* [cytosol] (R-HSA-9658926) PTEN E150* [cytosol] (R-HSA-9658920) PTEN E43* [cytosol] (R-HSA-9659049) PTEN Q17* [cytosol] (R-HSA-9659305) PTEN E91* [cytosol] (R-HSA-9659050) PTEN S59* [cytosol] (R-HSA-9659360) PTEN E114* [cytosol] (R-HSA-9658915) PTEN L139* [cytosol] (R-HSA-9659196) PTEN Y176* [cytosol] (R-HSA-9659389) PTEN Y177* [cytosol] (R-HSA-9659390) PTEN Q149* [cytosol] (R-HSA-9659320) PTEN L146* [cytosol] (R-HSA-9659193) PTEN G20* [cytosol] (R-HSA-9659129) PTEN G127* [cytosol] (R-HSA-9659130) PTEN Y46* [cytosol] (R-HSA-9659387) PTEN L182* [cytosol] (R-HSA-9659189) PTEN Q97* [cytosol] (R-HSA-9659318) PTEN Q171* [cytosol] (R-HSA-9659312) PTEN G129* [cytosol] (R-HSA-9659120) PTEN E18* [cytosol] (R-HSA-9658931) PTEN Y180* [cytosol] (R-HSA-9659404) PTEN K163* [cytosol] (R-HSA-9659148) PTEN Y27* [cytosol] (R-HSA-9659405) PTEN Y65* [cytosol] (R-HSA-9659406) PTEN Y68* [cytosol] (R-HSA-9659400) PTEN K128* [cytosol] (R-HSA-9659145) PTEN Y138* [cytosol] (R-HSA-9659402) PTEN K125* [cytosol] (R-HSA-9659147) PTEN Y88* [cytosol] (R-HSA-9659399) PTEN Q110* [cytosol] (R-HSA-9659328) PTEN L23* [cytosol] (R-HSA-9659201) PTEN E7* [cytosol] (R-HSA-9659036) PTEN C105* [cytosol] (R-HSA-9658911) PTEN E73* [cytosol] (R-HSA-9659039) PTEN K62* [cytosol] (R-HSA-9659160) PTEN E40* [cytosol] (R-HSA-9659032) PTEN Y178* [cytosol] (R-HSA-9659417) PTEN R130* [cytosol] (R-HSA-2318571) PTEN W111* [cytosol] (R-HSA-9659414) PTEN R11* [cytosol] (R-HSA-9659350) PTEN K13* [cytosol] (R-HSA-9659152) PTEN Y174* [cytosol] (R-HSA-9659409) PTEN K147* [cytosol] (R-HSA-9659153) PTEN R84* [cytosol] (R-HSA-9659347) PTEN G293* [cytosol] (R-HSA-9659113) PTEN S287* [cytosol] (R-HSA-9659371) PTEN Q214* [cytosol] (R-HSA-9659307) PTEN S229* [cytosol] (R-HSA-9659366) PTEN Q219* [cytosol] (R-HSA-9659302) PTEN Q261* [cytosol] (R-HSA-9659303) PTEN E299* [cytosol] (R-HSA-9659040) PTEN Y336* [cytosol] (R-HSA-9659388) PTEN Q245* [cytosol] (R-HSA-9659326) PTEN Y225* [cytosol] (R-HSA-9659391) PTEN Y240* [cytosol] (R-HSA-9659385) PTEN C218* [cytosol] (R-HSA-9659065) PTEN C250* [cytosol] (R-HSA-9659066) PTEN L247* [cytosol] (R-HSA-9659195) PTEN G209* [cytosol] (R-HSA-9659124) PTEN C211* [cytosol] (R-HSA-9659062) PTEN G230* [cytosol] (R-HSA-9659121) PTEN Q298* [cytosol] (R-HSA-9659314) PTEN L320* [cytosol] (R-HSA-9659187) PTEN E242* [cytosol] (R-HSA-9659084) PTEN K332* [cytosol] (R-HSA-9659151) PTEN E284* [cytosol] (R-HSA-9659087) PTEN E291* [cytosol] (R-HSA-9659081) PTEN K330* [cytosol] (R-HSA-9659146) PTEN E314* [cytosol] (R-HSA-9659078) PTEN Y346* [cytosol] (R-HSA-9659392) PTEN C296* [cytosol] (R-HSA-9659072) PTEN W274* [cytosol] (R-HSA-9659393) PTEN R233* [cytosol] (R-HSA-2318573) PTEN R335* [cytosol] (R-HSA-2318568) PTEN E256* [cytosol] (R-HSA-9659098) PTEN R189* [cytosol] (R-HSA-9659354) PTEN E307* [cytosol] (R-HSA-9659099) PTEN K263* [cytosol] (R-HSA-9659156) PTEN E235* [cytosol] (R-HSA-9659029) PTEN E288* [cytosol] (R-HSA-9659094) PTEN K221* [cytosol] (R-HSA-9659158) PTEN K344* [cytosol] (R-HSA-9659159) p-Y336-PTEN [cytosol] (R-HSA-8847980) K27polyUb-PTEN [cytosol] (R-HSA-8851009) PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (R-HSA-8948841) RibC-E40,E150,D326-PTEN [cytosol] (R-HSA-8948798) PolyUb-PTEN [cytosol] (R-HSA-6807280) K48polyUb-K289-PTEN [cytosol] (R-HSA-8948777) PTEN [cytosol] (R-HSA-199420) MonoUb-K13,K289-PTEN [cytosol] (R-HSA-6807247) MonoUb-K13,K289-PTEN [nucleoplasm] (R-HSA-6807264) PTEN [nucleoplasm] (R-HSA-6807273) p-3S,2T-PTEN [cytosol] (R-HSA-8850936)	0.462	2