Reactome | ANAPC4 [nucleoplasm]

ANAPC4 [nucleoplasm]

Stable Identifier

R-HSA-174115

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Apc4

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
      - Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        ANAPC4 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by VENTX (Homo sapiens)
      - Regulation of IL6 transcription (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        ANAPC4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UJX5 ANAPC4

Gene Names

ANAPC4, APC4

Chain

chain:1-808

Reference Genes

BioGPS Gene:29945 ANAPC4

COSMIC (genes):ANAPC4 ANAPC4

CTD Gene:29945 ANAPC4

dbSNP Gene:29945 ANAPC4

ENSEMBL:ENSG00000053900 ANAPC4

HGNC:19990 ANAPC4

KEGG:hsa:29945 ANAPC4

Monarch:29945 ANAPC4

NCBI Gene:29945 ANAPC4

OMIM:606947 ANAPC4

UCSC:Q9UJX5 ANAPC4

Reference Transcript

Other Identifiers

11720137_a_at

16965559

226917_PM_s_at

226917_s_at

232524_PM_x_at

232524_x_at

2721849

2721851

2721852

2721853

2721854

2721855

2721856

2721857

2721858

2721860

2721861

2721864

2721867

2721868

2721869

2721870

2721871

2721873

2721875

2721876

2721877

2721878

2721879

2721880

2721881

2721882

2721883

2721884

2721885

2721886

2721887

2721888

2721889

2721890

2721891

2721892

2721893

2721894

2721895

2721896

2721897

2721898

2721899

2721900

29945

44071_at

8094408

A_14_P100075

A_14_P121281

A_14_P201349

A_23_P317800

GE80321

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005680

GO:0005829

GO:0007346

GO:0016567

GO:0016740

GO:0019903

GO:0030071

GO:0030163

GO:0031145

GO:0034399

GO:0043226

GO:0051301

GO:0051445

GO:0070936

GO:0070979

GO:0140096

GO:0141198

HMNXSV003015003

Hs.273391.0.S1_3p_s_at

Hs.306420.0.S1_3p_s_at

ILMN_1802973

PH_hs_0025519

TC04000176.hg

Participates

as a component of

Other forms of this molecule

ANAPC4 [cytosol]

Inferred To

anapc4 [nucleoplasm] (Dictyostelium discoideum)

anapc4 [nucleoplasm] (Xenopus tropicalis)

ANAPC4 [nucleoplasm] (Bos taurus)

ANAPC4 [nucleoplasm] (Canis familiaris)

ANAPC4 [nucleoplasm] (Gallus gallus)

ANAPC4 [nucleoplasm] (Sus scrofa)

Anapc4 [nucleoplasm] (Mus musculus)

Anapc4 [nucleoplasm] (Rattus norvegicus)

APC4 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_037499.2, NP_001273685.1

OpenTargets

ENSG00000053900

ENSEMBL

ENSG00000053900, ENSP00000318775, ENSP00000426654, ENST00000510092, ENST00000315368

HPA

ENSG00000053900-ANAPC4

GeneCards

ANAPC4

PRO

Q9UJX5

Pharos - Targets

Q9UJX5

PDB

5A31, 5LCW, 6TM5, 5BPW, 6Q6G, 6Q6H, 5KHU, 4UI9, 5L9T, 5L9U, 6TNT, 8TAU, 6TLJ, 8PKP, 8TAR, 5G04, 5G05, 9GAW, 5KHR

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.823	12
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.794	10
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.725	7
UniProt:Q9UM11 FZR1	5	FZR1 [cytosol] (R-HSA-174249) FZR1 [nucleoplasm] (R-HSA-174099) p-FZR1 [nucleoplasm] (R-HSA-174257) p-FZR1 [cytosol] (R-HSA-174193) p-S151-FZR1 [nucleoplasm] (R-HSA-9929805)	0.643	5
UniProt:Q8NI77 KIF18A	1	KIF18A [cytosol] (R-HSA-376239)	0.623	3
UniProt:P51955 NEK2	1	NEK2 [cytosol] (R-HSA-177329)	0.623	7
UniProt:O43684 BUB3	1	BUB3 [cytosol] (R-HSA-141416)	0.527	2
UniProt:P31350 RRM2	1	RRM2 [cytosol] (R-HSA-73639)	0.527	2
UniProt:Q9UKT4 FBXO5	6	p-S182-FBXO5 [cytosol] (R-HSA-177324) p-S145,S149-FBXO5 [cytosol] (R-HSA-174207) FBXO5 [nucleoplasm] (R-HSA-174060) p-S182-FBXO5 [nucleoplasm] (R-HSA-176447) p-S145,S149-FBXO5 [nucleoplasm] (R-HSA-174220) p-FBXO5 [nucleoplasm] (R-HSA-163049)	0.527	2
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.462	2

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