Reactome | Association of Cyclin B:Cdc2 with Cdc20:APC/C complex

Association of Cyclin B:Cdc2 with Cdc20:APC/C complex

Stable Identifier

R-HSA-174120

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of Cyclin B (Homo sapiens)
        
        Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Homo sapiens)

General

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SVG | | PPTX | SBGN

Association of Cyclin B:Cdc2 with Cdc20:APC/C complex

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Cyclin B is believed to be recognized by the APC/C:Cdc20 complex through its D-box sequence.

Literature References

PubMed ID	Title	Journal	Year
11285280	Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint Geley, S, Kramer, E, Gieffers, C, Gannon, J, Peters, JM, Hunt, T	J Cell Biol	2001