Reactome | Association of Securin with Cdc20:APC/C complex

Association of Securin with Cdc20:APC/C complex

Stable Identifier

R-HSA-174121

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        Association of Securin with Cdc20:APC/C complex (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of Securin (Homo sapiens)
        
        Association of Securin with Cdc20:APC/C complex (Homo sapiens)

General

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SVG | | PPTX | SBGN

Association of Securin with Cdc20:APC/C complex

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Securin is thought to be recognized by the APC/C:Cdc20 complex through its conserved D-box sequence.

Literature References

PubMed ID	Title	Journal	Year
12070128	Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1 Hagting, A, Den Elzen, N, Vodermaier, HC, Waizenegger, IC, Peters, JM, Pines, J	J Cell Biol	2002