Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2

Stable Identifier
R-HSA-174122
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2
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Emi1 is also believed to be phosphorylated by Cyclin B:Cdc2 on a CDK consensus site at Ser 182. While Plk1 mediated phosphorylation of Emi1 at the DSGxxS (ßTrCP recognition) motif is essential for Emi1 destruction in mitosis, Cdk phosphorylation has been shown to play an important regulatory role.

Literature References
PubMed ID Title Journal Year
12791267 Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

Margottin-Goguet, F, Hsu, JY, Loktev, A, Hsieh, HM, Reimann, JD, Jackson, PK

Dev Cell 2003
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of CCNB1:p-T161-CDK1 [nucleoplasm]
Physical Entity
CCNB1:p-T161-CDK1 [nucleoplasm]
Activity
cyclin-dependent protein serine/threonine kinase activity (0004693)
Orthologous Events
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Bos taurus)
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Canis familiaris)
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Danio rerio)
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Drosophila melanogaster)
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Mus musculus)
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Rattus norvegicus)
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Sus scrofa)
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Xenopus tropicalis)
Authored
Lorca, T  (2006-01-26)
Castro, A  (2006-01-26)
Reviewed
Peters, JM  (2006-03-28)
Created
Matthews, L  (2006-02-17)