Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2

Stable Identifier
R-HSA-174122
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Emi1 is also believed to be phosphorylated by Cyclin B:Cdc2 on a CDK consensus site at Ser 182. While Plk1 mediated phosphorylation of Emi1 at the DSGxxS (ßTrCP recognition) motif is essential for Emi1 destruction in mitosis, Cdk phosphorylation has been shown to play an important regulatory role.

Literature References
PubMed ID Title Journal Year
12791267 Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

Margottin-Goguet, F, Hsu, JY, Loktev, A, Hsieh, HM, Reimann, JD, Jackson, PK

Dev Cell 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of CCNB1:p-T161-CDK1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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