Reactome | Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2

Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2

Stable Identifier

R-HSA-174122

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
        
        Phosphorylation of Emi1 (Homo sapiens)
        
        Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Homo sapiens)

General

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Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2

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Emi1 is also believed to be phosphorylated by Cyclin B:Cdc2 on a CDK consensus site at Ser 182. While Plk1 mediated phosphorylation of Emi1 at the DSGxxS (ßTrCP recognition) motif is essential for Emi1 destruction in mitosis, Cdk phosphorylation has been shown to play an important regulatory role.

Literature References

PubMed ID	Title	Journal	Year
12791267	Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase Margottin-Goguet, F, Hsu, JY, Loktev, A, Hsieh, HM, Reimann, JD, Jackson, PK	Dev Cell	2003