Reactome | Ubiquitination of Securin by phospho-APC/C:Cdc20 complex

Ubiquitination of Securin by phospho-APC/C:Cdc20 complex

Stable Identifier

R-HSA-174144

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of Securin (Homo sapiens)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Homo sapiens)

General

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Ubiquitination of Securin by phospho-APC/C:Cdc20 complex

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Securin is ubiquitinated by APC/C:Cdc20 (Hagting et al., 2002; Jin et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18485873	Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex Jin, L, Williamson, A, Banerjee, S, Philipp, I, Rape, M	Cell	2008
12070128	Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1 Hagting, A, Den Elzen, N, Vodermaier, HC, Waizenegger, IC, Peters, JM, Pines, J	J Cell Biol	2002