Ubiquitination of Securin by phospho-APC/C:Cdc20 complex

Stable Identifier
R-HSA-174144
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Securin is ubiquitinated by APC/C:Cdc20 (Hagting et al., 2002; Jin et al. 2008).

Literature References
PubMed ID Title Journal Year
18485873 Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex

Jin, L, Williamson, A, Banerjee, S, Philipp, I, Rape, M

Cell 2008
12070128 Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1

Hagting, A, Den Elzen, N, Vodermaier, HC, Waizenegger, IC, Peters, JM, Pines, J

J Cell Biol 2002
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of CDC20:p-APC/C [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created