Reactome | Ubiquitination of Securin by phospho-APC/C:Cdc20 complex

Ubiquitination of Securin by phospho-APC/C:Cdc20 complex

Stable Identifier

R-HSA-174144

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of Securin (Homo sapiens)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Ubiquitination of Securin by phospho-APC/C:Cdc20 complex

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Securin is ubiquitinated by APC/C:Cdc20 (Hagting et al., 2002; Jin et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18485873	Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex Jin, L, Williamson, A, Banerjee, S, Philipp, I, Rape, M	Cell	2008
12070128	Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1 Hagting, A, Den Elzen, N, Vodermaier, HC, Waizenegger, IC, Peters, JM, Pines, J	J Cell Biol	2002