Reactome | SKP1 [cytosol]

SKP1 [cytosol]

Stable Identifier

R-HSA-174150

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Skp1

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Locations in the PathwayBrowser for interactor UniProt:Q06587 RING1

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External Reference Information

External Reference

UniProt:P63208 SKP1

Gene Names

SKP1, EMC19, OCP2, SKP1A, TCEB1L

Chain

initiator methionine:, chain:2-163

Reference Genes

COSMIC (genes):SKP1 SKP1

dbSNP Gene:6500 SKP1

ENSEMBL:ENSG00000113558 SKP1

Participates

as a component of

as an input of

Other forms of this molecule

SKP1 [nucleoplasm]

Inferred To

SkpA [cytosol] (Drosophila melanogaster)

fpaB-1 [cytosol] (Dictyostelium discoideum)

skp1 [cytosol] (Danio rerio)

skp1 [cytosol] (Schizosaccharomyces pombe)

skp1 [cytosol] (Xenopus tropicalis)

SKP1 [cytosol] (Bos taurus)

SKP1 [cytosol] (Canis familiaris)

SKP1 [cytosol] (Gallus gallus)

SKP1 [cytosol] (Plasmodium falciparum)

SKP1 [cytosol] (Saccharomyces cerevisiae)

SKP1 [cytosol] (Sus scrofa)

Skp1 [cytosol] (Mus musculus)

Skp1 [cytosol] (Rattus norvegicus)

Homologues of SKP1 [cytosol] (Dictyostelium discoideum)

fpaA [cytosol] (Dictyostelium discoideum)

skr-1 [cytosol] (Caenorhabditis elegans)

Interactors (108)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.962	27
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.957	20
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.952	18
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.934	14
UniProt:Q86XK2 FBXO11	1	FBXO11 [cytosol] (R-HSA-8955092)	0.92	11
UniProt:Q9NVF7 FBX28			0.909	14
UniProt:Q9UKA1 FBXL5	1	FBXL5 [cytosol] (R-HSA-391295)	0.905	15
UniProt:Q96CD0 FBXL8	1	FBXL8 [cytosol] (R-HSA-8850912)	0.905	17
UniProt:Q9UKT5 FBXO4	1	FBXO4 [cytosol] (R-HSA-391298)	0.904	19
UniProt:Q96EF6 FBXO17	1	FBXO17 [cytosol] (R-HSA-976036)	0.895	19
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.891	11
UniProt:Q9UK99 FBX3			0.888	12
UniProt:Q9UK22 FBXO2	1	FBXO2 [cytosol] (R-HSA-976044)	0.851	14
UniProt:Q9UKC9 FBXL2			0.847	9
UniProt:Q8NHM5 KDM2B	1	KDM2B [nucleoplasm] (R-HSA-3214398)	0.839	8
UniProt:Q8N5M4 TTC9C			0.832	13
UniProt:Q969H0 FBXW7	1	FBXW7 [cytosol] (R-HSA-391304)	0.821	11
UniProt:Q9UKT8 FBXW2	1	FBXW2 [cytosol] (R-HSA-391300)	0.818	7
UniProt:Q969U6 FBXW5	1	FBXW5 [cytosol] (R-HSA-391286)	0.818	7
UniProt:Q9H4M3 FBXO44	1	FBXO44 [cytosol] (R-HSA-976031)	0.801	8
UniProt:Q9UKT4 FBXO5	6	p-S182-FBXO5 [cytosol] (R-HSA-177324) p-S145,S149-FBXO5 [cytosol] (R-HSA-174207) FBXO5 [nucleoplasm] (R-HSA-174060) p-S182-FBXO5 [nucleoplasm] (R-HSA-176447) p-S145,S149-FBXO5 [nucleoplasm] (R-HSA-174220) p-FBXO5 [nucleoplasm] (R-HSA-163049)	0.801	8
UniProt:Q9NRD1 FBXO6	1	FBXO6 [cytosol] (R-HSA-391296)	0.8	9
UniProt:Q9NXK8 FBXL12	1	FBXL12 [cytosol] (R-HSA-8862611)	0.8	10
UniProt:Q8NEZ5 FBXO22	1	FBXO22 [cytosol] (R-HSA-8862600)	0.8	10
UniProt:Q8N1E6 FBXL14	1	FBXL14 [cytosol] (R-HSA-8862603)	0.8	6
UniProt:Q6PJ61 FBX46			0.788	7
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.784	7
UniProt:Q6P050 FBXL22	1	FBXL22 [cytosol] (R-HSA-8862597)	0.765	7
UniProt:Q9Y2K7 KDM2A	1	KDM2A [nucleoplasm] (R-HSA-3214392)	0.744	6
UniProt:Q96IG2 FBXL20	1	FBXL20 [cytosol] (R-HSA-8862591)	0.742	7
UniProt:Q9UF56 FBXL17	1	FBXL17 [nucleoplasm] (R-HSA-9708570)	0.737	16
UniProt:Q6W2J9 BCOR			0.725	5
UniProt:Q9H469 FBXL15	1	FBXL15 [cytosol] (R-HSA-8862625)	0.725	6
UniProt:Q9BSM1 PCGF1			0.725	6
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.725	6
UniProt:Q5XUX1 FBXW9	1	FBXW9 [cytosol] (R-HSA-391290)	0.716	7
UniProt:O94952 FBXO21	1	FBXO21 [cytosol] (R-HSA-8862592)	0.708	10
UniProt:P54253 ATX1			0.696	6
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.692	3
UniProt:Q8N3Y1 FBXW8	1	FBXW8 [cytosol] (R-HSA-976017)	0.669	5
UniProt:Q7Z6M2 FBX33			0.669	5
UniProt:P57775 FBXW4	1	FBXW4 [cytosol] (R-HSA-391305)	0.669	3
UniProt:Q9UK97 FBXO9	1	FBXO9 [cytosol] (R-HSA-8862608)	0.669	5
UniProt:Q9H4M3-2 FBXO44			0.666	6
UniProt:Q8TCJ0-3 FBXO25			0.666	4
UniProt:P41002 CCNF	1	CCNF [cytosol] (R-HSA-8862602)	0.662	9
UniProt:Q8N531 FBXL6			0.659	3
UniProt:Q6P3S6 FBX42			0.643	5
UniProt:Q99496 RNF2	1	RNF2 [nucleoplasm] (R-HSA-389119)	0.643	5
UniProt:P20248 CCNA2	3	CCNA2 [nucleoplasm] (R-HSA-68905) CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099)	0.643	4
UniProt:P62877 RBX1	2	RBX1 [cytosol] (R-HSA-180582) RBX1 [nucleoplasm] (R-HSA-1234142)	0.643	3
UniProt:Q6PCT2 FBXL19	1	FBXL19 [cytosol] (R-HSA-8862607)	0.643	5
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.643	5
UniProt:Q8TB52 FBXO30	1	FBXO30 [cytosol] (R-HSA-8862619)	0.643	5
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.641	4
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.638	3
UniProt:P11440 Cdk1	11	phospho-p-T161-CDK1 [nucleoplasm] (R-MMU-170066) phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (R-MMU-170074) phospho-p-T161-CDK1 [cytosol] (R-MMU-157415) phospho-p-T14,Y15,T161-CDK1 [cytosol] (R-MMU-170071) CDK1 [cytosol] (R-MMU-170075) phospho-p-T14,T161-CDK1 [nucleoplasm] (R-MMU-170078) phospho-p-T14-CDK1 [nucleoplasm] (R-MMU-170045) phospho-p-T14-CDK1 [cytosol] (R-MMU-170064) Cdk1 [nucleoplasm] (R-MMU-1362302) phospho-p-Y4-CDK1 [cytosol] (R-MMU-9836187) CDK1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.623	3
UniProt:Q5XUX0 FBXO31	1	FBXO31 [cytosol] (R-HSA-8850911)	0.564	4
UniProt:Q4G163 FBX43			0.556	3
UniProt:Q8NI29 FBXO27	1	FBXO27 [cytosol] (R-HSA-976039)	0.556	3
UniProt:Q96IX9 A26L1			0.556	3
UniProt:A0A0B4J1Y2 A0A0B4J1Y2			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q7L273 KCTD9			0.556	3
IntAct:EBI-22514577 CCSB ORF ID			0.556	3
UniProt:Q13309-2 SKP2			0.556	5
UniProt:P25791 LMO2	1	LMO2 [nucleoplasm] (R-HSA-8956513)	0.556	3
IntAct:EBI-10220632 119369			0.556	3
UniProt:Q9UK97-2 FBXO9			0.556	3
UniProt:Q5FWF7 FBX48			0.556	5
UniProt:Q9ULD2-3 MTUS1			0.556	3
UniProt:Q96GX9 APIP	1	APIP [cytosol] (R-HSA-1237171)	0.556	3
UniProt:Q8BFZ4	1	Fbxl21 [cytosol] (R-MMU-8862606)	0.547	3
UniProt:Q8C4V4 Fbxl3	2	Fbxl3 [nucleoplasm] (R-MMU-508623) Fbxl3 [cytosol] (R-MMU-391289)	0.547	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.547	2
UniProt:Q9Y2Z0-2 SUGT1			0.544	2
UniProt:P38936 CDKN1A	5	p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) CDKN1A [nucleoplasm] (R-HSA-182585) CDKN1A [cytosol] (R-HSA-182512) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.536	3
UniProt:Q15052 ARHGEF6	1	ARHGEF6 [cytosol] (R-HSA-195017)	0.527	3
UniProt:Q9UH90 FBXO40	1	FBXO40 [cytosol] (R-HSA-8862612)	0.527	3
UniProt:Q8WUF8 ARB2A			0.527	4
UniProt:Q96ME1 FBXL18	1	FBXL18 [cytosol] (R-HSA-8854063)	0.527	4
UniProt:P63167 DYNLL1	6	DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.527	2
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.527	2
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.527	3
UniProt:Q008S8 ECT2L			0.527	2
UniProt:Q9ULD2 MTUS1			0.527	4
UniProt:Q8NFZ0 FBH1			0.527	4
UniProt:Q8TCJ0 FBX25			0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.527	13
UniProt:P0C2W1 FBSP1			0.527	4
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.527	3
UniProt:O75592 MYCB2			0.527	4
UniProt:Q6PIJ6 FBX38			0.527	4
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [cytosol] (R-HSA-400305) p-S-CRY2 [nucleoplasm] (R-HSA-400328) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.527	4
UniProt:Q9UK96 FBXO10	1	FBXO10 [cytosol] (R-HSA-8862618)	0.527	3
UniProt:Q9UKA2 FBXL4	1	FBXL4 [cytosol] (R-HSA-8850899)	0.527	4
UniProt:Q5H9F3 BCORL			0.527	2
UniProt:Q14999 CUL7	1	CUL7 [cytosol] (R-HSA-535534)	0.527	4
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.527	3
UniProt:Q16526 CRY1	4	Ub-p-S-CRY1 [nucleoplasm] (R-HSA-517931) CRY1 [cytosol] (R-HSA-400247) p-S-CRY1 [nucleoplasm] (R-HSA-400340) p-S-CRY1 [cytosol] (R-HSA-400270)	0.527	4
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.527	3
UniProt:Q9HC35 EML4	12	EML4 [cytosol] (R-HSA-9647741) p-S,T-EML4 [cytosol] (R-HSA-9648096) EML4(1-496)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699812) EML4(1-223)-ALK(1059-1620) fusion [cytosol] (R-HSA-9699862) EML4(1-223)insKMSTREKNSQV-ALK(1059-1620) fusion [cytosol] (R-HSA-9699813) EML4(1-780)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9716113) EML4(1-569)-p-7Y-ALK(1078-1620) fusion [cytosol] (R-HSA-9716116) EML4(1-223)-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9699903) EML4(1-223)insKMSTREKNSQV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9699885) EML4(1-486)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699918) EML4(1-569)-ALK(1078-1620) fusion [cytosol] (R-HSA-9716112) EML4(1-780)-ALK(1058-1620) fusion [cytosol] (R-HSA-9716119)	0.527	3
UniProt:Q92530 PSMF1	1	PSMF1 [cytosol] (R-HSA-68818)	0.527	4
UniProt:P46527 CDKN1B	8	p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.524	2
UniProt:P61962 DCAF7	2	Unfolded DCAF7 [cytosol] (R-HSA-6813821) DCAF7 [nucleoplasm] (R-HSA-8863312)	0.508	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	2
UniProt:P49768 PSEN1	6	PSEN1(1-467) [plasma membrane] (R-HSA-201606) PSEN1(299-467) [azurophil granule membrane] (R-HSA-6799234) PSEN1(1-467) [azurophil granule membrane] (R-HSA-6799235) PSEN1(1-298) [azurophil granule membrane] (R-HSA-6799209) PSEN1(1-298) [plasma membrane] (R-HSA-2534298) PSEN1(299-467) [plasma membrane] (R-HSA-2534245)	0.462	3
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	4

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