Reactome | SKP1 [cytosol]

SKP1 [cytosol]

Stable Identifier

R-HSA-174150

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Skp1

Locations in the PathwayBrowser for interactor UniProt:Q9UKB1 FBXW11

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External Reference Information

External Reference

UniProt:P63208 SKP1

Gene Names

SKP1, EMC19, OCP2, SKP1A, TCEB1L

Chain

initiator methionine:1, chain:2-163

Reference Genes

BioGPS Gene:6500 SKP1

COSMIC (genes):SKP1 SKP1

CTD Gene:6500 SKP1

dbSNP Gene:6500 SKP1

ENSEMBL:ENSG00000113558 SKP1

HGNC:10899 SKP1

KEGG Gene (Homo sapiens):6500 SKP1

Monarch:6500 SKP1

NCBI Gene:6500 SKP1

OMIM:601434 SKP1

UCSC:P63208 SKP1

Reference Transcript

Other Identifiers

0001940128

0001940577

11715417_s_at

11715418_x_at

11722822_a_at

11722823_a_at

17124738

200711_s_at

200718_s_at

200719_at

2010_at

207974_s_at

2876004

2876006

2876008

2876010

2876012

2876013

2876014

2876015

2876016

2876017

2876018

2876019

2876020

2876021

2876022

2876023

2876024

2876027

2876033

2876035

2876040

2876041

2876042

3053874

3406766

41759_at

6500

77520_at

79190_at

8114152

8180312

A_23_P133424

A_23_P133432

GE580771

GE79084

GE85116

GE85893

GO:0000086

GO:0000209

GO:0000278

GO:0002223

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006464

GO:0006511

GO:0006879

GO:0006950

GO:0007049

GO:0007165

GO:0007267

GO:0008013

GO:0008150

GO:0009056

GO:0010265

GO:0010972

GO:0016032

GO:0016055

GO:0016567

GO:0019005

GO:0019904

GO:0022607

GO:0030674

GO:0031146

GO:0031467

GO:0031519

GO:0032991

GO:0035518

GO:0038061

GO:0038095

GO:0042592

GO:0043226

GO:0043687

GO:0044403

GO:0050852

GO:0051276

GO:0051403

GO:0051457

GO:0065003

GO:0070498

GO:0070936

GO:0097602

GO:1901990

GO:1904668

GO:1990444

GO:1990756

Hs.171626.0.S1_3p_a_at

Hs.171626.0.S3_3p_at

ILMN_1711766

ILMN_1790710

ILMN_1872218

ILMN_3229770

PH_hs_0010274

Z47087_at

g5902087_3p_s_at

g6006030_3p_a_at

Participant Of

hasComponent

input

Other forms of this molecule

SKP1 [nucleoplasm]

Inferred To

SkpA [cytosol] (Drosophila melanogaster)

fpaB-1 [cytosol] (Dictyostelium discoideum)

skp1 [cytosol] (Danio rerio)

skp1 [cytosol] (Schizosaccharomyces pombe)

skp1 [cytosol] (Xenopus tropicalis)

SKP1 [cytosol] (Bos taurus)

SKP1 [cytosol] (Canis familiaris)

SKP1 [cytosol] (Gallus gallus)

SKP1 [cytosol] (Plasmodium falciparum)

SKP1 [cytosol] (Saccharomyces cerevisiae)

SKP1 [cytosol] (Sus scrofa)

Skp1 [cytosol] (Mus musculus)

Skp1 [cytosol] (Rattus norvegicus)

Homologues of SKP1 [cytosol] (Dictyostelium discoideum)

fpaA [cytosol] (Dictyostelium discoideum)

skr-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_733779.1, NP_008861.2

Target Pathogen

5b354852be737e166372e948

OpenTargets

ENSG00000113558

HPA

ENSG00000113558-SKP1

GeneCards

P63208

Ensembl

ENSP00000429961, ENSP00000429686, ENSG00000113558, ENST00000517625, ENSP00000231487, ENST00000522552, ENSP00000429472, ENST00000353411, ENST00000522855

PRO

P63208

PDB

1P22, 1LDK, 6M90, 5JH5, 6C16, 1FQV, 2OVP, 6BVA, 2E31, 2OVQ, 2AST, 2OVR, 6O60, 5IBK, 6M92, 3L2O, 5XYL, 2E32, 6M91, 1FS1, 6M93, 6TTU, 6BYH, 6M94, 5VZT, 1FS2, 3WSO, 5VZU, 6WNX, 5V4B, 4I6J, 5K35, 2ASS

Interactors (82)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13616 CUL1	3	CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [cytosol] (R-HSA-174230)	0.954	17
UniProt:Q9Y297 BTRC	2	BTRC [nucleoplasm] (R-HSA-3361753) BTRC [cytosol] (R-HSA-174237)	0.954	20
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073)	0.945	14
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.931	11
UniProt:Q86XK2 FBXO11	1	FBXO11 [cytosol] (R-HSA-8955092)	0.888	8
UniProt:Q9NVF7 FBX28			0.876	11
UniProt:Q96CD0 FBXL8	1	FBXL8 [cytosol] (R-HSA-8850912)	0.871	14
UniProt:Q9UKT5 FBXO4	1	FBXO4 [cytosol] (R-HSA-391298)	0.871	16
UniProt:Q96EF6 FBXO17	1	FBXO17 [cytosol] (R-HSA-976036)	0.86	16
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.854	8
UniProt:Q9UK99 FBX3			0.851	9
UniProt:Q9UKA1 FBXL5	1	FBXL5 [cytosol] (R-HSA-391295)	0.831	12
UniProt:Q969H0 FBXW7	1	FBXW7 [cytosol] (R-HSA-391304)	0.821	11
UniProt:Q9UK22 FBXO2	1	FBXO2 [cytosol] (R-HSA-976044)	0.806	11
UniProt:Q9UKC9 FBXL2			0.801	6
UniProt:Q8N5M4 TTC9C			0.782	10
UniProt:Q969U6 FBXW5	1	FBXW5 [cytosol] (R-HSA-391286)	0.763	4
UniProt:Q9UKT8 FBXW2	1	FBXW2 [cytosol] (R-HSA-391300)	0.763	4
UniProt:Q9H4M3 FBXO44	1	FBXO44 [cytosol] (R-HSA-976031)	0.743	5
UniProt:Q9UKT4 FBXO5	6	p-S182-FBXO5 [nucleoplasm] (R-HSA-176447) p-S145,S149-FBXO5 [nucleoplasm] (R-HSA-174220) p-S145,S149-FBXO5 [cytosol] (R-HSA-174207) p-S182-FBXO5 [cytosol] (R-HSA-177324) p-FBXO5 [nucleoplasm] (R-HSA-163049) FBXO5 [nucleoplasm] (R-HSA-174060)	0.743	5
UniProt:Q8N1E6 FBXL14	1	FBXL14 [cytosol] (R-HSA-8862603)	0.742	5
UniProt:Q8NEZ5 FBXO22	1	FBXO22 [cytosol] (R-HSA-8862600)	0.742	7
UniProt:Q9NRD1 FBXO6	1	FBXO6 [cytosol] (R-HSA-391296)	0.742	8
UniProt:Q9NXK8 FBXL12	1	FBXL12 [cytosol] (R-HSA-8862611)	0.742	7
UniProt:Q6PJ61 FBX46			0.728	4
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.723	4
UniProt:P35222 CTNNB1	33	CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.713	3
UniProt:P54253 ATX1			0.696	6
UniProt:Q8NHM5 KDM2B	1	KDM2B [nucleoplasm] (R-HSA-3214398)	0.669	3
UniProt:Q9Y2K7 KDM2A	1	KDM2A [nucleoplasm] (R-HSA-3214392)	0.669	3
UniProt:Q96IG2 FBXL20	1	FBXL20 [cytosol] (R-HSA-8862591)	0.666	4
UniProt:Q8TCJ0-3 FBXO25			0.666	4
UniProt:Q9H4M3-2 FBXO44			0.666	6
UniProt:Q6W2J9 BCOR			0.643	3
UniProt:Q9H469 FBXL15	1	FBXL15 [cytosol] (R-HSA-8862625)	0.643	3
UniProt:Q9BSM1 PCGF1			0.643	4
UniProt:P24941 CDK2	5	p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.643	4
UniProt:Q5XUX1 FBXW9	1	FBXW9 [cytosol] (R-HSA-391290)	0.632	4
UniProt:P11440 Cdk1	10	phospho-Cdk1 [nucleoplasm] (R-MMU-170074) phospho-Cdk1 [nucleoplasm] (R-MMU-170078) phospho-Cdk1 [nucleoplasm] (R-MMU-170045) phospho-Cdk1 [cytosol] (R-MMU-170064) phospho-Cdk1 [cytosol] (R-MMU-170071) phospho-Cdk1 [cytosol] (R-MMU-157415) phospho-Cdk1 [nucleoplasm] (R-MMU-170066) Cdk1 [cytosol] (R-MMU-170075) Cdk1 [nucleoplasm] (R-MMU-1362302) Cdk1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.623	3
UniProt:P38936 CDKN1A	5	p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-T145-CDKN1A [cytosol] (R-HSA-198614) CDKN1A [cytosol] (R-HSA-182512) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) CDKN1A [nucleoplasm] (R-HSA-182585)	0.589	3
UniProt:Q8N3Y1 FBXW8	1	FBXW8 [cytosol] (R-HSA-976017)	0.564	2
UniProt:P57775 FBXW4	1	FBXW4 [cytosol] (R-HSA-391305)	0.564	2
UniProt:Q9UK97 FBXO9	1	FBXO9 [cytosol] (R-HSA-8862608)	0.564	2
UniProt:Q7Z6M2 FBX33			0.564	2
UniProt:P41002 CCNF	1	CCNF [cytosol] (R-HSA-8862602)	0.558	6
UniProt:Q4G163 FBX43			0.556	3
UniProt:Q8NI29 FBXO27	1	FBXO27 [cytosol] (R-HSA-976039)	0.556	3
UniProt:P25791 LMO2	1	LMO2 [nucleoplasm] (R-HSA-8956513)	0.556	3
UniProt:Q6P050 FBXL22	1	FBXL22 [cytosol] (R-HSA-8862597)	0.556	3
IntAct:EBI-10220632 119369			0.556	3
UniProt:Q96IX9 A26L1			0.556	3
UniProt:Q9UK97-2 FBXO9			0.556	3
UniProt:A0A0B4J1Y2 A0A0B4J1Y2			0.556	3
UniProt:Q5FWF7 FBX48			0.556	5
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q7L273 KCTD9			0.556	3
IntAct:EBI-22514577 CCSB ORF ID			0.556	3
UniProt:Q13309-2 SKP2			0.556	5
UniProt:Q9ULD2-3 MTUS1			0.556	3
UniProt:Q96GX9 APIP	1	APIP [cytosol] (R-HSA-1237171)	0.556	3
UniProt:Q8N531 FBXL6			0.547	2
UniProt:Q8BFZ4	1	Fbxl21 [cytosol] (R-MMU-8862606)	0.547	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.547	2
UniProt:Q8C4V4 Fbxl3	2	Fbxl3 [cytosol] (R-MMU-391289) Fbxl3 [nucleoplasm] (R-MMU-508623)	0.547	3
UniProt:Q9Y2Z0-2 SUGT1			0.544	2
UniProt:Q8TCJ0 FBX25			0.527	2
UniProt:Q6PCT2 FBXL19	1	FBXL19 [cytosol] (R-HSA-8862607)	0.527	2
UniProt:Q15843 NEDD8	17	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) K1881-CUL9-G76-NEDD8 [cytosol] (R-HSA-8955924) NEDD8 [nucleoplasm] (R-HSA-8955926) K705-CUL4A-G76-NEDD8 [nucleoplasm] (R-HSA-8952528) K859-CUL4B-G76-NEDD8 [nucleoplasm] (R-HSA-8952538) NEDD8(77-88) [cytosol] (R-HSA-6782654) NEDD8(1-88) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) K720-CUL1-G76-NEDD8 [cytosol] (R-HSA-8952534) K712-CUL3-G76-NEDD8 [cytosol] (R-HSA-8952531) K689-CUL2-G76-NEDD8 [cytosol] (R-HSA-8952526) K724-CUL5-G76-NEDD8 [cytosol] (R-HSA-8952018) NEDD8 [cytosol] (R-HSA-416969) K567-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419906) K556-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419907) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	3
UniProt:Q6P3S6 FBX42			0.527	2
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.527	3
UniProt:Q99496 RNF2	1	RNF2 [nucleoplasm] (R-HSA-389119)	0.527	3
UniProt:Q8TB52 FBXO30	1	FBXO30 [cytosol] (R-HSA-8862619)	0.527	2
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.527	2
UniProt:P62877 RBX1	2	RBX1 [cytosol] (R-HSA-180582) RBX1 [nucleoplasm] (R-HSA-1234142)	0.527	2
UniProt:P20248 CCNA2	3	CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [nucleoplasm] (R-HSA-68905)	0.527	2
UniProt:P46527 CDKN1B	8	CDKN1B [nucleoplasm] (R-HSA-182563) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.524	2
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.524	3
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.508	2
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cytosol] (R-HSA-2029024)	0.508	2
UniProt:P49768 PSEN1	6	PSEN1(299-467) [azurophil granule membrane] (R-HSA-6799234) PSEN1(1-467) [plasma membrane] (R-HSA-201606) PSEN1(1-467) [azurophil granule membrane] (R-HSA-6799235) PSEN1(1-298) [azurophil granule membrane] (R-HSA-6799209) PSEN1(1-298) [plasma membrane] (R-HSA-2534298) PSEN1(299-467) [plasma membrane] (R-HSA-2534245)	0.462	3
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	4
UniProt:P30304 CDC25A	6	p-S123-CDC25A [nucleoplasm] (R-HSA-143488) CDC25A [nucleoplasm] (R-HSA-143487) CDC25A [cytosol] (R-HSA-157410) p-S123-CDC25A [cytosol] (R-HSA-69588) p-S40,S116,S261-CDC25A [nucleoplasm] (R-HSA-8863634) PolyUb-CDC25A [cytosol] (R-HSA-6782810)	0.462	2

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