Reactome | ANAPC5 [nucleoplasm]

ANAPC5 [nucleoplasm]

Stable Identifier

R-HSA-174153

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Apc5

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
      - Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        ANAPC5 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by VENTX (Homo sapiens)
      - Regulation of IL6 transcription (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        ANAPC5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UJX4 ANAPC5

Gene Names

ANAPC5, APC5

Chain

chain:1-755

Reference Genes

BioGPS Gene:51433 ANAPC5

COSMIC (genes):ANAPC5 ANAPC5

CTD Gene:51433 ANAPC5

dbSNP Gene:51433 ANAPC5

ENSEMBL:ENSG00000089053 ANAPC5

HGNC:15713 ANAPC5

KEGG:hsa:51433 ANAPC5

Monarch:51433 ANAPC5

NCBI Gene:51433 ANAPC5

OMIM:606948 ANAPC5

UCSC:Q9UJX4 ANAPC5

Reference Transcript

Other Identifiers

11715599_a_at

16651927

16651929

16651967

16651969

16651971

16651975

16651977

16651979

16651981

16651983

16652011

16652013

16652081

16652591

16652593

16652631

16652633

16652635

16652639

16652641

16652643

16652645

16652647

16652675

16652677

16771463

18670994

18670995

18670996

18670997

18670998

18670999

18671000

18671001

18671002

18671003

18671004

18671005

18671006

18671007

18671008

18671009

18671010

18671011

18671012

18671013

18671014

18671015

18671016

18671017

18671018

18671019

18671020

18671021

18671022

18671023

18671024

18671025

18671026

18671027

18671028

200098_PM_s_at

200098_s_at

208721_PM_s_at

208721_s_at

208722_PM_s_at

208722_s_at

211036_PM_x_at

211036_x_at

235926_PM_at

235926_at

239651_PM_at

239651_at

3474936

3474937

3474938

3474939

3474940

3474941

3474942

3474943

3474947

3474948

3474949

3474950

3474951

3474952

3474953

3474956

3474957

3474958

3474959

3474960

3474961

3474962

3474963

3474964

3474965

3474966

3474967

3474968

3474969

3474970

3474971

3474972

3474973

3474974

3474975

3474976

3474977

3474978

3474979

3474980

3474981

3474982

3474983

3474984

3474985

3475040

3475042

3475044

3475046

3475048

3475050

3475072

3475074

3475076

3475078

3475096

3475098

3475100

3475106

3475108

3475110

3475112

3475114

3475116

3475148

3475150

3475152

3475154

3475178

35835_at

51433

56530_r_at

68060_at

7892634

7892775

7892908

7892964

7893097

7893148

7893346

7893415

7893501

7893529

7893593

7893717

7893761

7893821

7893856

7893862

7893908

7893948

7894095

7894176

7894232

7894295

7894316

7894574

7894665

7894711

7895027

7895032

7895042

7895065

7895338

7895432

7895438

7895548

7895658

7895803

7895856

7895978

7896071

7896192

7896205

7896241

7896269

7896299

7896336

7896562

7896627

7967149

83571_at

88272_at

90637_at

A_23_P204448

A_23_P377830

GE62916

GE79326

GE795975

GE85760

GO:0005515

GO:0005634

GO:0005654

GO:0005680

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0007346

GO:0016567

GO:0019903

GO:0030163

GO:0031145

GO:0043226

GO:0045842

GO:0051301

GO:0051445

GO:0070936

GO:0070979

GO:0141198

HMNXSV003049276

Hs.155766.0.A1_3p_at

Hs.189394.0.A1_3p_at

Hs.7101.0.S1_3p_s_at

ILMN_1723177

PH_hs_0000724

PH_hs_0009383

TC12002062.hg

g12654502_3p_s_at

Participates

as a component of

Other forms of this molecule

ANAPC5 [cytosol]

Inferred To

ANAPC5 [nucleoplasm] (Bos taurus)

ANAPC5 [nucleoplasm] (Canis familiaris)

ANAPC5 [nucleoplasm] (Gallus gallus)

ANAPC5 [nucleoplasm] (Sus scrofa)

Anapc5 [nucleoplasm] (Mus musculus)

Anapc5 [nucleoplasm] (Rattus norvegicus)

ida [nucleoplasm] (Drosophila melanogaster)

anapc5 [nucleoplasm] (Dictyostelium discoideum)

anapc5 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_057321.2, NP_001317418.1, NP_001131031.1

OpenTargets

ENSG00000089053

ENSEMBL

ENST00000261819, ENSP00000261819, ENST00000441917, ENSG00000089053, ENSP00000415061

HPA

ENSG00000089053-ANAPC5

GeneCards

ANAPC5

PRO

Q9UJX4

Pharos - Targets

Q9UJX4

PDB

5LCW, 5A31, 6TM5, 6Q6H, 6Q6G, 4UI9, 5KHU, 5L9T, 5L9U, 6TNT, 8TAU, 6TLJ, 8PKP, 8TAR, 5G04, 5G05, 9GAW, 5KHR

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9JJ66	3	Cdc20 [nucleoplasm] (R-MMU-6783069) Cdc20 [nucleoplasm] (R-MMU-174112) Cdc20 [cytosol] (R-MMU-141412)	0.564	2
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.527	4
UniProt:Q9Y468 L3MBTL1	1	L3MBTL1 [nucleoplasm] (R-HSA-3222110)	0.527	2
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.527	2
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.462	2

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