APC/C:Cdc20 mediated degradation of Securin

Stable Identifier
R-HSA-174154
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Pathway
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Homo sapiens
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The separation of sister chromatids in anaphase requires the destruction of the anaphase inhibitor, securin. Securin associates with and inactivates the protease, separase. Separase cleaves the cohesin subunit, Scc1 that is responsible for the cohesion of sister chromatids (reviewed in Nasmyth et al., 2000). Securin destruction begins at metaphase after the mitotic spindle checkpoint has been satisfied (Hagting et al., 2002).

Literature References
PubMed ID Title Journal Year
12070128 Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1

Hagting, A, Den Elzen, N, Vodermaier, HC, Waizenegger, IC, Peters, JM, Pines, J

J Cell Biol 2002
10827941 Splitting the chromosome: cutting the ties that bind sister chromatids

Nasmyth, K, Peters, JM, Uhlmann, F

Science 2000
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Orthologous Events
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