Cdc20:Phospho-APC/C mediated degradation of Cyclin A

Stable Identifier
R-HSA-174184
Type
Pathway
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Cyclin A, functions in mitosis as well as DNA replication and is degraded in the interim by the APC/C to permit normal chromosome segregation, cell division, and the onset of S phase (see Lukas and Bartek, 2004). Cyclin A is initially degraded early in mitosis by APC/C:Cdc20 when the spindle checkpoint is still active and degradation of securin and cyclin B is inhibited.
Literature References
PubMed ID Title Journal Year
11285280 Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint

Peters, JM, Gannon, J, Geley, S, Kramer, E, Gieffers, C, Hunt, T

J Cell Biol 2001
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Participates
Event Information
Orthologous Events
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