Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex

Stable Identifier
R-HSA-174195
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the beginning of this reaction, 3 molecules of 'ubiquitin', and 1 molecule of 'cell cycle proteins:phospho-APC/C:Cdh1 complex' are present. At the end of this reaction, 1 molecule of 'multiubiquitinated cell cycle protein:APC/C:Cdh1 complex' is present.

This reaction takes place in the 'cytosol' and is mediated by the 'ubiquitin-protein ligase activity' of 'cell cycle proteins:phospho-APC/C:Cdh1 complex' (Rape et al.1996).

Literature References
PubMed ID Title Journal Year
16413484 The processivity of multiubiquitination by the APC determines the order of substrate degradation

Rape, M, Reddy, SK, Kirschner, MW

Cell 2006
15678131 The anaphase-promoting complex: a key factor in the regulation of cell cycle

Castro, A, Bernis, C, Vigneron, S, Labbe, JC, Lorca, T

Oncogene 2005
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created