Phosphorylated Emi1 binds the beta-TrCP in the SCF complex

Stable Identifier
R-HSA-174209
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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Phosphorylated Emi1 binds the beta-TrCP in the SCF complex
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cdk mediated phosphorylation of Emi1 is believed to promotes its phospho- Ser145-Ser149 dependent association with beta-TrCP.

Literature References
PubMed ID Title Journal Year
10023660 The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin

Latres, E, Chiaur, DS, Pagano, M

Oncogene 1999
12791267 Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

Margottin-Goguet, F, Hsu, JY, Loktev, A, Hsieh, HM, Reimann, JD, Jackson, PK

Dev Cell 2003
Participants
Input
Output
Participant Of
hasEvent
Authored
Lorca, T  (2006-01-26)
Castro, A  (2006-01-26)
Reviewed
Peters, JM  (2006-03-28)
Created
Matthews, L  (2006-02-17)
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