Phosphorylated Emi1 binds the beta-TrCP in the SCF complex

Stable Identifier
R-HSA-174209
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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Phosphorylated Emi1 binds the beta-TrCP in the SCF complex
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Cdk mediated phosphorylation of Emi1 is believed to promotes its phospho- Ser145-Ser149 dependent association with beta-TrCP.

Literature References
PubMed ID Title Journal Year
10023660 The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin

Latres, E, Chiaur, DS, Pagano, M

Oncogene 1999
12791267 Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

Margottin-Goguet, F, Hsu, JY, Loktev, A, Hsieh, HM, Reimann, JD, Jackson, PK

Dev Cell 2003
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Input
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Authored
Lorca, T  (2006-01-26)
Castro, A  (2006-01-26)
Reviewed
Peters, JM  (2006-03-28)
Created
Matthews, L  (2006-02-17)
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