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CDC26 [nucleoplasm]
Stable Identifier
R-HSA-174216
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cdc26
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1 polyubiquitinates SKP2 (Homo sapiens)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
RB1 recruits APC/C:Cdh1 complex to SKP2 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
Phosphorylation of the APC/C (Homo sapiens)
Free APC/C phosphorylated by Cyclin B:Cdc2 (Homo sapiens)
anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Free APC/C phosphorylated by Plk1 (Homo sapiens)
anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Multiubiquitination of APC/C-associated Cdh1 (Homo sapiens)
multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
Association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Dissociation of phospho-Cdh1 from the APC/C complex (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Cdh1:APC/C complex binds EHMT1:EHMT2 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Homo sapiens)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Stimulation of IL8 transcription in senescent cells (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of mitotic cell cycle (Homo sapiens)
Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by VENTX (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
CDC26 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NHZ8 CDC26
Gene Names
CDC26, ANAPC12, C9orf17
Chain
chain:1-85
Reference Genes
BioGPS Gene:246184 CDC26
COSMIC (genes):CDC26 CDC26
CTD Gene:246184 CDC26
dbSNP Gene:246184 CDC26
ENSEMBL:ENSG00000176386 CDC26
HGNC:17839 CDC26
KEGG:hsa:246184 CDC26
Monarch:246184 CDC26
NCBI Gene:246184 CDC26
OMIM:614533 CDC26
UCSC:Q8NHZ8 CDC26
Reference Transcript
RefSeq:XM_017014573.1 CDC26
RefSeq:NM_139286.3 CDC26
RefSeq:XM_017014575.1 CDC26
RefSeq:XM_017014574.1 CDC26
Other Identifiers
11757062_at
11757063_s_at
17097423
225422_PM_at
225422_at
246184
3072161
3072162
3072163
3221544
3221545
3221546
3221547
3221550
3221551
3221554
3221555
3221556
3221558
45771_at
8142878
8163481
A_32_P228501
GO:0005515
GO:0005634
GO:0005654
GO:0005680
GO:0005829
GO:0007346
GO:0016567
GO:0030163
GO:0031145
GO:0043226
GO:0051301
GO:0051445
GO:0070936
GO:0070979
GO:0141198
HMNXSV003027019
Hs.3991.0.A1_3p_at
ILMN_2210837
PH_hs_0027435
PH_hs_0035902
TC09002917.hg
Participates
as a component of
anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
CDC26 [cytosol]
Inferred To
CDC26 [nucleoplasm]
(Bos taurus)
CDC26 [nucleoplasm]
(Canis familiaris)
CDC26 [nucleoplasm]
(Gallus gallus)
CDC26 [nucleoplasm]
(Sus scrofa)
Ghost homologue of CDC26 [nucleoplasm]
(Drosophila melanogaster)
cdc26 [nucleoplasm]
(Dictyostelium discoideum)
cdc26 [nucleoplasm]
(Xenopus tropicalis)
Cdc26 [nucleoplasm]
(Mus musculus)
Cdc26 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
XP_016870062.1
,
NP_644815.1
,
XP_016870063.1
,
XP_016870064.1
OpenTargets
ENSG00000176386
ENSEMBL
ENSP00000363322
,
ENST00000374206
HPA
ENSG00000176386-CDC26
PRO
Q8NHZ8
Pharos - Targets
Q8NHZ8
PDB
6TLJ
,
8PKP
,
6TM5
,
6Q6G
,
8S4G
,
7QE7
,
5G05
,
5G04
,
8TAR
,
5KHR
,
4UI9
,
5LCW
,
5KHU
,
5A31
,
3HYM
,
6Q6H
,
5L9T
,
5L9U
,
6TNT
,
8TAU
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UKT4 FBXO5
6
p-S182-FBXO5 [cytosol]
(R-HSA-177324)
p-S145,S149-FBXO5 [cytosol]
(R-HSA-174207)
FBXO5 [nucleoplasm]
(R-HSA-174060)
p-S182-FBXO5 [nucleoplasm]
(R-HSA-176447)
p-S145,S149-FBXO5 [nucleoplasm]
(R-HSA-174220)
p-FBXO5 [nucleoplasm]
(R-HSA-163049)
0.643
4
UniProt:Q9Z1S0
1
BUB1B [cytosol]
(R-MMU-141436)
0.564
2
UniProt:Q9JJ66
3
Cdc20 [nucleoplasm]
(R-MMU-6783069)
Cdc20 [nucleoplasm]
(R-MMU-174112)
Cdc20 [cytosol]
(R-MMU-141412)
0.564
2
UniProt:Q12834 CDC20
3
CDC20 [cytosol]
(R-HSA-141412)
CDC20 [nucleoplasm]
(R-HSA-174112)
PolyUb-CDC20 [nucleoplasm]
(R-HSA-6783069)
0.527
3
UniProt:Q9UM11 FZR1
4
FZR1 [cytosol]
(R-HSA-174249)
FZR1 [nucleoplasm]
(R-HSA-174099)
p-FZR1 [nucleoplasm]
(R-HSA-174257)
p-FZR1 [cytosol]
(R-HSA-174193)
0.527
3
UniProt:P51955 NEK2
1
NEK2 [cytosol]
(R-HSA-177329)
0.527
2
UniProt:O60566 BUB1B
1
BUB1B [cytosol]
(R-HSA-141436)
0.527
2
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