Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex

Stable Identifier
R-HSA-174227
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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At the beginning of this reaction, 1 molecule of 'Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex', and 3 molecules of 'ubiquitin' are present. At the end of this reaction, 1 molecule of 'multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex' is present.

This reaction takes place in the 'cytosol' and is mediated by the 'ubiquitin-protein ligase activity' of 'Cdc20:Phospho-APC/C'.

Literature References
PubMed ID Title Journal Year
11285280 Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint

Geley, S, Kramer, E, Gieffers, C, Gannon, J, Peters, JM, Hunt, T

J Cell Biol 2001
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of CDC20:p-APC/C [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created