Reactome | CUL1 [cytosol]

CUL1 [cytosol]

Stable Identifier

R-HSA-174230

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cul1

Locations in the PathwayBrowser for interactor UniProt:P24941

Expand all

External Reference Information

External Reference

UniProt:Q13616 CUL1

Gene Names

CUL1

Chain

chain:1-776

Reference Genes

BioGPS Gene:8454 CUL1

COSMIC (genes):CUL1 CUL1

CTD Gene:8454 CUL1

dbSNP Gene:8454 CUL1

ENSEMBL:ENSG00000055130 CUL1

HGNC:2551 CUL1

KEGG Gene (Homo sapiens):8454 CUL1

Monarch:8454 CUL1

NCBI Gene:8454 CUL1

OMIM:603134 CUL1

UCSC:Q13616 CUL1

Reference Transcript

Other Identifiers

0000670731

11716819_a_at

11747353_a_at

17053019

207614_s_at

2874246

3030286

3030287

3030288

3030289

3030290

3030299

3030300

3030301

3030302

3030312

3030313

3030314

3030315

3030316

3030317

3030320

3030321

3030337

3030338

3030339

3030340

3030342

3030343

3030345

3030349

3030354

3030355

3030357

3030359

3030361

3030362

3030363

3030369

39723_at

39724_s_at

8137054

8454

A_23_P59657

A_24_P303589

GE54578

GO:0000082

GO:0000086

GO:0000209

GO:0000278

GO:0002223

GO:0002376

GO:0003674

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006511

GO:0006513

GO:0006879

GO:0006915

GO:0006950

GO:0007049

GO:0007165

GO:0007267

GO:0008150

GO:0008219

GO:0008283

GO:0009056

GO:0009887

GO:0010265

GO:0010972

GO:0016032

GO:0016055

GO:0016567

GO:0019005

GO:0019899

GO:0022607

GO:0031146

GO:0031461

GO:0031625

GO:0032991

GO:0038061

GO:0038095

GO:0042592

GO:0043226

GO:0043687

GO:0044403

GO:0048856

GO:0050852

GO:0051403

GO:0065003

GO:0070498

GO:0070936

GO:0097193

GO:1901990

GO:1990452

HMNXSV003016400

ILMN_1749629

PH_hs_0023905

TC07000969.hg

U58087_at

g4503160_3p_a_at

Participates

as a component of

as a member of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

as an input of

Other forms of this molecule

G76-NEDD8-K720-CUL1 [cytosol]

CUL1 [nucleoplasm]

Inferred To

Cul1 [cytosol] (Drosophila melanogaster)

Cul1 [cytosol] (Mus musculus)

Cul1 [cytosol] (Rattus norvegicus)

cul1a [cytosol] (Danio rerio)

culA [cytosol] (Dictyostelium discoideum)

Ghost homologue of CUL1 [cytosol] (Xenopus tropicalis)

cul1 [cytosol] (Schizosaccharomyces pombe)

CUL1 [cytosol] (Bos taurus)

CUL1 [cytosol] (Canis familiaris)

CUL1 [cytosol] (Gallus gallus)

CUL1 [cytosol] (Plasmodium falciparum)

CUL1 [cytosol] (Sus scrofa)

CDC53 [cytosol] (Saccharomyces cerevisiae)

cul-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

XP_011514932.1, XP_005250117.1, NP_003583.2, XP_011514933.1, XP_011514931.1, XP_011514934.1

OpenTargets

ENSG00000055130

HPA

ENSG00000055130-CUL1

GeneCards

Q13616

Ensembl

ENST00000662716, ENST00000665936, ENSP00000326804, ENST00000325222, ENST00000602748, ENST00000409469, ENSP00000473318, ENSP00000387160, ENST00000663044, ENSP00000499255, ENSG00000055130, ENSP00000499277, ENSP00000499398

PRO

Q13616

PDB

6TTU, 3TDU, 3TDZ, 1U6G, 1LDJ, 5V89, 4P5O, 3RTR, 1LDK, 6WCQ, 4F52

Interactors (60)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62877 RBX1	2	RBX1 [cytosol] (R-HSA-180582) RBX1 [nucleoplasm] (R-HSA-1234142)	0.973	24
UniProt:Q15843 NEDD8	17	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) K1881-CUL9-G76-NEDD8 [cytosol] (R-HSA-8955924) NEDD8 [nucleoplasm] (R-HSA-8955926) K705-CUL4A-G76-NEDD8 [nucleoplasm] (R-HSA-8952528) K859-CUL4B-G76-NEDD8 [nucleoplasm] (R-HSA-8952538) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-88) [cytosol] (R-HSA-6782654) NEDD8(1-88) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) K720-CUL1-G76-NEDD8 [cytosol] (R-HSA-8952534) K712-CUL3-G76-NEDD8 [cytosol] (R-HSA-8952531) K689-CUL2-G76-NEDD8 [cytosol] (R-HSA-8952526) K724-CUL5-G76-NEDD8 [cytosol] (R-HSA-8952018) K567-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419906) K556-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419907) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969)	0.957	19
UniProt:Q86VP6 CAND1	5	CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399) CAND1 [nucleoplasm] (R-HSA-8955089) CAND1 [extracellular region] (R-HSA-6806498) CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [cytosol] (R-HSA-5691146)	0.956	33
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.954	17
UniProt:Q9Y297 BTRC	2	BTRC [nucleoplasm] (R-HSA-3361753) BTRC [cytosol] (R-HSA-174237)	0.928	13
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.924	13
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073)	0.823	15
UniProt:P61081 UBE2M	5	G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) AcM-UBE2M [nucleoplasm] (R-HSA-8952502) UBE2M [cytosol] (R-HSA-947619) G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894) AcM-UBE2M [cytosol] (R-HSA-8951627)	0.786	5
UniProt:Q969H0 FBXW7	1	FBXW7 [cytosol] (R-HSA-391304)	0.784	6
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.758	10
UniProt:Q9UKT5 FBXO4	1	FBXO4 [cytosol] (R-HSA-391298)	0.758	4
UniProt:Q92905 COPS5	2	COPS5 [cytosol] (R-HSA-416963) COPS5 [nucleoplasm] (R-HSA-5697019)	0.737	14
UniProt:Q9Y4X5 ARIH1	1	ARIH1 [cytosol] (R-HSA-1678825)	0.708	8
UniProt:Q86XK2 FBXO11	1	FBXO11 [cytosol] (R-HSA-8955092)	0.69	7
UniProt:Q9UKT8 FBXW2	1	FBXW2 [cytosol] (R-HSA-391300)	0.688	6
UniProt:Q96GG9 DCUN1D1	2	DCUN1D1 [cytosol] (R-HSA-8951781) DCUN1D1 [nucleoplasm] (R-HSA-8952487)	0.669	7
UniProt:Q9NRD1 FBXO6	1	FBXO6 [cytosol] (R-HSA-391296)	0.669	3
UniProt:Q96EF6 FBXO17	1	FBXO17 [cytosol] (R-HSA-976036)	0.662	8
UniProt:P41002 CCNF	1	CCNF [cytosol] (R-HSA-8862602)	0.662	5
UniProt:Q5XUX0 FBXO31	1	FBXO31 [cytosol] (R-HSA-8850911)	0.643	4
UniProt:Q9H469 FBXL15	1	FBXL15 [cytosol] (R-HSA-8862625)	0.643	6
UniProt:P20248 CCNA2	3	CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [nucleoplasm] (R-HSA-68905)	0.643	3
IntAct:EBI-4399559 UBIQ			0.623	3
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.623	11
UniProt:P46527 CDKN1B	8	CDKN1B [nucleoplasm] (R-HSA-182563) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.609	2
UniProt:Q8N1E6 FBXL14	1	FBXL14 [cytosol] (R-HSA-8862603)	0.597	4
UniProt:Q6P3S6 FBX42			0.597	7
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.597	4
UniProt:Q8TCJ0 FBX25			0.577	3
UniProt:O60826 CCDC22	2	CCDC22 [cytosol] (R-HSA-8955640) CCDC22 [nucleoplasm] (R-HSA-8955644)	0.576	3
UniProt:Q969U6 FBXW5	1	FBXW5 [cytosol] (R-HSA-391286)	0.564	3
UniProt:Q7Z6M2 FBX33			0.564	2
UniProt:Q13309-1 SKP2			0.564	3
UniProt:O94888 UBXN7	1	UBXN7 [cytosol] (R-HSA-8956071)	0.564	8
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	2
UniProt:P67809 YBX1	2	YBX1 [extracellular region] (R-HSA-9017791) YBX1 [nucleoplasm] (R-HSA-72041)	0.564	2
UniProt:Q9UK99 FBX3			0.558	7
UniProt:P62837 UBE2D2	4	Ub-C85-UBE2D2 [cytosol] (R-HSA-8864214) Ub-C85-UBE2D2 [nucleoplasm] (R-HSA-8864153) UBE2D2 [nucleoplasm] (R-HSA-8852067) UBE2D2 [cytosol] (R-HSA-934628)	0.558	2
UniProt:Q83730 MT5			0.556	5
UniProt:Q8BFZ4	1	Fbxl21 [cytosol] (R-MMU-8862606)	0.547	3
UniProt:Q8C4V4 Fbxl3	2	Fbxl3 [cytosol] (R-MMU-391289) Fbxl3 [nucleoplasm] (R-MMU-508623)	0.547	3
UniProt:P49427 CDC34	4	Ub-C93-CDC34 [nucleoplasm] (R-HSA-8864204) Ub-C93-CDC34 [cytosol] (R-HSA-8864170) CDC34 [nucleoplasm] (R-HSA-8852125) CDC34 [cytosol] (R-HSA-947621)	0.544	3
UniProt:Q16526 CRY1	4	CRY1 [cytosol] (R-HSA-400247) Ub-p-S-CRY1 [nucleoplasm] (R-HSA-517931) p-S-CRY1 [nucleoplasm] (R-HSA-400340) p-S-CRY1 [cytosol] (R-HSA-400270)	0.527	2
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.527	2
UniProt:Q9NXK8 FBXL12	1	FBXL12 [cytosol] (R-HSA-8862611)	0.527	2
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.527	4
UniProt:P24941 CDK2	5	CDK2 [cytosol] (R-HSA-157440) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.527	3
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.524	3
UniProt:Q8NEZ5 FBXO22	1	FBXO22 [cytosol] (R-HSA-8862600)	0.499	4
UniProt:Q6TVW2 Q6TVW2			0.499	5
UniProt:P61201 COPS2	2	COPS2 [nucleoplasm] (R-HSA-5697012) COPS2 [cytosol] (R-HSA-416971)	0.462	6
UniProt:Q8N3Y1 FBXW8	1	FBXW8 [cytosol] (R-HSA-976017)	0.462	2
UniProt:Q9UBW8 COPS7A	2	COPS7A [nucleoplasm] (R-HSA-5697011) COPS7A [cytosol] (R-HSA-416964)	0.462	6
UniProt:O94952 FBXO21	1	FBXO21 [cytosol] (R-HSA-8862592)	0.462	6
UniProt:Q96ME1 FBXL18	1	FBXL18 [cytosol] (R-HSA-8854063)	0.462	6
UniProt:Q99627 COPS8	2	COPS8 [nucleoplasm] (R-HSA-5697014) COPS8 [cytosol] (R-HSA-416962)	0.462	6
UniProt:Q13098 GPS1	2	GPS1 [nucleoplasm] (R-HSA-5697010) GPS1 [cytosol] (R-HSA-416972)	0.462	5
UniProt:Q9H9Q2 COPS7B	2	COPS7B [nucleoplasm] (R-HSA-5697023) COPS7B [cytosol] (R-HSA-416966)	0.462	6
UniProt:Q9BT78 COPS4	2	COPS4 [nucleoplasm] (R-HSA-5697020) COPS4 [cytosol] (R-HSA-416965)	0.462	6
UniProt:Q9UNS2 COPS3	2	COPS3 [cytosol] (R-HSA-416973) COPS3 [nucleoplasm] (R-HSA-5697017)	0.462	6

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