Reactome | BTRC [cytosol]

BTRC [cytosol]

Stable Identifier

R-HSA-174237

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Beta-TrCP, F-box/WD repeat-containing protein 1A

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Locations in the PathwayBrowser for interactor UniProt:Q5JTC6 AMER1

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
        
        SCF-beta-TrCP mediated degradation of Emi1 (Homo sapiens)
        
        Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Homo sapiens)
        
        BTRC [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y297 BTRC

Gene Names

BTRC, BTRCP, FBW1A, FBXW1A

Chain

chain:1-605

Reference Genes

COSMIC (genes):BTRC BTRC

dbSNP Gene:8945 BTRC

ENSEMBL:ENSG00000166167 BTRC

Participates

as an input of

as an output of

BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins (Homo sapiens)

as a component of

as a member of

Other forms of this molecule

BTRC [nucleoplasm]

Inferred To

btrc [cytosol] (Xenopus tropicalis)

BTRC [cytosol] (Plasmodium falciparum)

Ghost homologue of BTRC [cytosol] (Bos taurus)

Ghost homologue of BTRC [cytosol] (Caenorhabditis elegans)

Ghost homologue of BTRC [cytosol] (Canis familiaris)

Ghost homologue of BTRC [cytosol] (Danio rerio)

Ghost homologue of BTRC [cytosol] (Dictyostelium discoideum)

Ghost homologue of BTRC [cytosol] (Drosophila melanogaster)

Ghost homologue of BTRC [cytosol] (Gallus gallus)

Ghost homologue of BTRC [cytosol] (Mus musculus)

Ghost homologue of BTRC [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of BTRC [cytosol] (Schizosaccharomyces pombe)

Ghost homologue of BTRC [cytosol] (Sus scrofa)

Btrc [cytosol] (Rattus norvegicus)

Interactors (58)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.962	27
UniProt:P18848 ATF4	2	ATF4 [cytosol] (R-HSA-381084) ATF4 [nucleoplasm] (R-HSA-381016)	0.951	21
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.932	15
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.926	8
UniProt:Q9C026 TRIM9	1	TRIM9 [cytosol] (R-HSA-976054)	0.831	8
UniProt:P30304 CDC25A	6	CDC25A [nucleoplasm] (R-HSA-143487) CDC25A [cytosol] (R-HSA-157410) p-S124-CDC25A [nucleoplasm] (R-HSA-143488) p-S124-CDC25A [cytosol] (R-HSA-69588) p-S40,S116,S261-CDC25A [nucleoplasm] (R-HSA-8863634) PolyUb-CDC25A [cytosol] (R-HSA-6782810)	0.812	8
UniProt:Q13127 REST	1	REST [nucleoplasm] (R-HSA-480506)	0.766	10
UniProt:O75410 TACC1			0.743	5
UniProt:P49427 CDC34	4	Ub-C93-CDC34 [cytosol] (R-HSA-8864170) Ub-C93-CDC34 [nucleoplasm] (R-HSA-8864204) CDC34 [nucleoplasm] (R-HSA-8852125) CDC34 [cytosol] (R-HSA-947621)	0.734	6
UniProt:O75410-7 TACC1			0.718	6
UniProt:Q5JTC6 AMER1	5	AMER1 R497* [cytosol] (R-HSA-9663943) AMER1 S210* [cytosol] (R-HSA-5251492) AMER1 R358* [cytosol] (R-HSA-4839640) AMER1 R353* [cytosol] (R-HSA-9663939) AMER1 [cytosol] (R-HSA-1504189)	0.688	7
UniProt:Q13651 IL10RA	3	p-Y446-IL10RA [plasma membrane] (R-HSA-6784810) p-Y496-IL10RA [plasma membrane] (R-HSA-6784793) IL10RA [plasma membrane] (R-HSA-449841)	0.675	6
UniProt:O00444 PLK4	1	PLK4 [cytosol] (R-HSA-380286)	0.675	4
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.669	6
UniProt:Q5D1E8 ZC3H12A	1	ZC3H12A [nucleoplasm] (R-HSA-9774235)	0.667	3
UniProt:Q8WWW0 RASF5			0.666	4
UniProt:Q9C026-5 TRIM9			0.666	4
UniProt:P46937 YAP1	8	YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y407-YAP1 [cytosol] (R-HSA-9865208)	0.659	3
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.643	4
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.597	3
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.597	5
UniProt:P69700 VPU			0.593	3
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.591	9
UniProt:P10070 GLI2	11	GLI2 [ciliary tip] (R-HSA-5610363) GLI2 [ciliary base] (R-HSA-5610361) 2p-GLI2 [nucleoplasm] (R-HSA-5635055) p-GLI2 [nucleoplasm] (R-HSA-5635047) p-GLI2 [ciliary tip] (R-HSA-5635044) GLI2 [cytosol] (R-HSA-445451) ub-p11S-GLI2 [ciliary base] (R-HSA-5610501) p11S-GLI2 [ciliary base] (R-HSA-5610471) p8S-GLI2 [ciliary base] (R-HSA-5610494) p4S-GLI2 [ciliary base] (R-HSA-5610487) ub-2p-GLI2 [nucleoplasm] (R-HSA-5635059)	0.576	4
UniProt:P25963 NFKBIA	9	NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) PolyUb-NFKBIA [cytosol] (R-HSA-6782960)	0.564	2
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.564	2
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.564	2
UniProt:Q9GZV5 WWTR1	3	WWTR1 [nucleoplasm] (R-HSA-1629775) WWTR1 [cytosol] (R-HSA-1629773) p-S89-WWTR1 [cytosol] (R-HSA-2028665)	0.564	2
UniProt:P49821 NDUFV1	1	NDUFV1 [mitochondrial inner membrane] (R-HSA-163926)	0.556	3
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837) MAP2K1 [cytosol] (R-HSA-59502) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) MAP2K1 F53C [cytosol] (R-HSA-9652028) MAP2K1 P124Q [cytosol] (R-HSA-9652058) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 F53L [cytosol] (R-HSA-9652031)	0.556	3
UniProt:Q9Y2T1 AXIN2	4	AXIN2 [cytosol] (R-HSA-3640821) ub-AXIN2 [cytosol] (R-HSA-4641131) RibC-AXIN2 [cytosol] (R-HSA-3640842) Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859)	0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:Q16621 NFE2	1	NFE2 [nucleoplasm] (R-HSA-1008221)	0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:Q9NQ86 TRIM36	1	TRIM36 [cytosol] (R-HSA-976029)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q8WWW0-2 RASSF5			0.556	3
UniProt:Q5HYW2 NHSL2			0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9NS23 RASF1			0.547	2
UniProt:P57078 RIPK4			0.547	2
UniProt:P15822 ZEP1			0.527	3
UniProt:O76031 CLPX	1	CLPX [mitochondrial matrix] (R-HSA-9838010)	0.527	3
UniProt:Q96K76 USP47	1	USP47 [nucleoplasm] (R-HSA-5696961)	0.527	4
UniProt:Q8IX03 WWC1	1	WWC1 [cytosol] (R-HSA-2038400)	0.527	2
UniProt:P32314 FOXN2			0.527	3
UniProt:P31629 ZEP2			0.527	3
UniProt:Q9Y266 NUDC	4	NUDC [cytosol] (R-HSA-377731) NUDC [nucleoplasm] (R-HSA-156716) p-S274,S326-NUDC [cytosol] (R-HSA-156702) p-S274,S326-NUDC [spindle] (R-HSA-9648125)	0.527	3
UniProt:O60285 NUAK1	2	p-T211-NUAK1 [nucleoplasm] (R-HSA-3222011) NUAK1 [nucleoplasm] (R-HSA-3222004)	0.527	2
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.527	3
UniProt:Q62696 Dlg1	4	Dlg1 [plasma membrane] (R-RNO-9617427) Dlg1 [endoplasmic reticulum membrane] (R-RNO-9610616) Dlg1 [cytosol] (R-RNO-416332) Dlg1 [plasma membrane] (R-RNO-375977)	0.524	3
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.524	2
UniProt:P63209 SKP1			0.508	2
UniProt:Q3KP66 INAVA			0.499	2
UniProt:Q76N32 CEP68			0.499	2
UniProt:P30291 WEE1	3	WEE1 [nucleoplasm] (R-HSA-69253) p-S53-WEE1 [nucleoplasm] (R-HSA-156694) p-WEE1 [nucleoplasm] (R-HSA-156491)	0.499	2
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.488	2
UniProt:Q9NX09 DDIT4	1	DDIT4 [cytosol] (R-HSA-5632374)	0.462	2

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