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PSME3 [nucleoplasm]
Stable Identifier
R-HSA-174310
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome activator complex subunit 3, Proteasome activator 28-gamma subunit, PA28gamma, PA28g, Activator of multicatalytic protease subunit 3, 11S regulator complex gamma subunit, REG-gamma, Ki nuclear autoantigen
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME3 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME3 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME3 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME3 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME3 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME3 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME3 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME3 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61289 PSME3
Gene Names
PSME3
Chain
initiator methionine:1, chain:2-254
Reference Genes
BioGPS Gene:10197 PSME3
COSMIC (genes):PSME3 PSME3
CTD Gene:10197 PSME3
dbSNP Gene:10197 PSME3
ENSEMBL:ENSG00000131467 PSME3
HGNC:9570 PSME3
KEGG Gene (Homo sapiens):10197 PSME3
Monarch:10197 PSME3
NCBI Gene:10197 PSME3
OMIM:605129 PSME3
UCSC:P61289 PSME3
Reference Transcript
RefSeq:NM_005789.3 PSME3
RefSeq:NM_176863.2 PSME3
Other Identifiers
0004560075
10197
11729131_a_at
11729132_a_at
11756207_s_at
16834486
200987_x_at
200988_s_at
209852_x_at
209853_s_at
3722156
3722157
3722158
3722159
3722160
3722162
3722163
3722164
3722165
3722166
3722167
3722168
3722170
3722171
3722172
3722173
3722174
3722175
3722177
3722178
3722179
3722180
3722181
3722183
3722184
3722185
3722186
3722187
39796_at
8007397
A_23_P164141
A_24_P344307
GE61895
GO:0000165
GO:0000209
GO:0000278
GO:0000502
GO:0002039
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006520
GO:0006521
GO:0006810
GO:0006915
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0008219
GO:0008537
GO:0009056
GO:0009058
GO:0010950
GO:0010972
GO:0016020
GO:0016032
GO:0016579
GO:0030154
GO:0030234
GO:0031145
GO:0031146
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0038061
GO:0038095
GO:0042802
GO:0043161
GO:0043226
GO:0043488
GO:0043687
GO:0044281
GO:0044403
GO:0048856
GO:0050852
GO:0055085
GO:0060071
GO:0061133
GO:0061136
GO:0061418
GO:0070498
GO:0090090
GO:0090263
GO:0097371
GO:1901990
GO:1902036
GO:2000045
GO:2001237
Hs.152978.0.A1_3p_a_at
ILMN_1800975
ILMN_2346573
PH_hs_0009198
TC17000538.hg
U11292_at
g12655138_3p_a_at
g12803696_3p_a_at
g5031996_3p_a_at
Participant Of
hasComponent
26S proteasome [nucleoplasm]
Other forms of this molecule
PSME3 [cytosol]
Inferred To
PSME3 [nucleoplasm] (Caenorhabditis elegans)
PSME3 [nucleoplasm] (Canis familiaris)
PSME3 [nucleoplasm] (Sus scrofa)
psme3 [nucleoplasm] (Danio rerio)
psme3 [nucleoplasm] (Xenopus tropicalis)
Psme3 [nucleoplasm] (Mus musculus)
Psme3 [nucleoplasm] (Rattus norvegicus)
psmE3 [nucleoplasm] (Dictyostelium discoideum)
REG [nucleoplasm] (Drosophila melanogaster)
Cross References
RefSeq
NP_005780.2
,
NP_789839.1
OpenTargets
ENSG00000131467
HPA
ENSG00000131467-PSME3
GeneCards
P61289
Ensembl
ENST00000590720
,
ENSG00000131467
,
ENST00000441946
,
ENSP00000466794
,
ENSP00000409487
,
ENST00000293362
,
ENSP00000293362
PRO
P61289
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96JC9 EAF1
1
EAF1 [nucleoplasm]
(R-HSA-8932787)
0.841
9
UniProt:Q9BXC9 BBS2
1
BBS2 [cytosol]
(R-HSA-5617637)
0.781
7
UniProt:Q96CJ1 EAF2
1
EAF2 [nucleoplasm]
(R-HSA-8932790)
0.621
3
UniProt:Q00987 MDM2
11
SUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.612
8
UniProt:Q9Y6Q9 NCOA3
2
p-S857 NCOA3 [nucleoplasm]
(R-HSA-5687005)
NCOA3 [nucleoplasm]
(R-HSA-442488)
0.602
5
UniProt:Q9HCE7 SMURF1
2
SMURF1 [cytosol]
(R-HSA-975972)
SMURF1 [nucleoplasm]
(R-HSA-3004548)
0.593
5
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.576
7
UniProt:P42677 RPS27
2
RPS27 [cytosol]
(R-HSA-72361)
RPS27 [nucleoplasm]
(R-HSA-6791190)
0.556
3
UniProt:P30305 CDC25B
3
CDC25B [cytosol]
(R-HSA-157412)
p-S50,T69,S160,S321,S470-CDC25B [cytosol]
(R-HSA-8863644)
CDC25B [nucleoplasm]
(R-HSA-69734)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
PICK1 [plasma membrane]
(R-HSA-416989)
0.556
3
UniProt:Q99757 TXN2
3
2xHC-TXN2 [mitochondrial matrix]
(R-HSA-3323059)
TXN2 [mitochondrial matrix]
(R-HSA-3323048)
HC-TXN2 [mitochondrial matrix]
(R-HSA-9035482)
0.556
3
UniProt:P0DTC9 N
10
phospho-SUMO1-K62-ADPr-p-S177-Ncap [cytosol]
(R-COV-9694558)
phospho-SUMO1-K62-ADPr-p-S177-Ncap [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694424)
phospho-ADPr-p-S177-Ncap [cytosol]
(R-COV-9694254)
phospho-p-S177-Ncap [cytosol]
(R-COV-9694472)
Ncap [cytosol]
(R-COV-9694300)
Ncap [plasma membrane]
(R-COV-9694356)
phospho-SUMO1-K62-ADPr-p-S177-Ncap [nucleolus]
(R-COV-9694318)
phospho-SUMO1-K62-ADPr-p-S177-Ncap [plasma membrane]
(R-COV-9694764)
N [cytosol]
(R-COV-9694314)
phospho-p-S177,S181,S185,S187,S189,S191,S195,T199,S203,S207-N [cytosol]
(R-COV-9694431)
0.544
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
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