Reactome | PSME3 [nucleoplasm]

PSME3 [nucleoplasm]

Stable Identifier

R-HSA-174310

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proteasome activator complex subunit 3, Proteasome activator 28-gamma subunit, PA28gamma, PA28g, Activator of multicatalytic protease subunit 3, 11S regulator complex gamma subunit, REG-gamma, Ki nuclear autoantigen

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P61289 PSME3

Gene Names

PSME3

Chain

initiator methionine:1, chain:2-254

Reference Genes

BioGPS Gene:10197 PSME3

COSMIC (genes):PSME3 PSME3

CTD Gene:10197 PSME3

dbSNP Gene:10197 PSME3

ENSEMBL:ENSG00000131467 PSME3

HGNC:9570 PSME3

KEGG Gene (Homo sapiens):10197 PSME3

Monarch:10197 PSME3

NCBI Gene:10197 PSME3

OMIM:605129 PSME3

UCSC:P61289 PSME3

Reference Transcript

Other Identifiers

0004560075

10197

11729131_a_at

11729132_a_at

11756207_s_at

16834486

200987_x_at

200988_s_at

209852_x_at

209853_s_at

3722156

3722157

3722158

3722159

3722160

3722162

3722163

3722164

3722165

3722166

3722167

3722168

3722170

3722171

3722172

3722173

3722174

3722175

3722177

3722178

3722179

3722180

3722181

3722183

3722184

3722185

3722186

3722187

39796_at

8007397

A_23_P164141

A_24_P344307

GE61895

GO:0000165

GO:0000209

GO:0000278

GO:0000502

GO:0002039

GO:0002223

GO:0002376

GO:0002479

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006464

GO:0006520

GO:0006521

GO:0006810

GO:0006915

GO:0006950

GO:0007049

GO:0007165

GO:0007267

GO:0008150

GO:0008219

GO:0008537

GO:0009056

GO:0009058

GO:0010950

GO:0010972

GO:0016020

GO:0016032

GO:0016579

GO:0030154

GO:0030234

GO:0031145

GO:0031146

GO:0032991

GO:0033209

GO:0034641

GO:0034655

GO:0038061

GO:0038095

GO:0042802

GO:0043161

GO:0043226

GO:0043488

GO:0043687

GO:0044281

GO:0044403

GO:0048856

GO:0050852

GO:0055085

GO:0060071

GO:0061133

GO:0061136

GO:0061418

GO:0070498

GO:0090090

GO:0090263

GO:0097371

GO:1901990

GO:1902036

GO:2000045

GO:2001237

Hs.152978.0.A1_3p_a_at

ILMN_1800975

ILMN_2346573

PH_hs_0009198

TC17000538.hg

U11292_at

g12655138_3p_a_at

g12803696_3p_a_at

g5031996_3p_a_at

Participant Of

hasComponent

26S proteasome [nucleoplasm]

Other forms of this molecule

PSME3 [cytosol]

Inferred To

PSME3 [nucleoplasm] (Caenorhabditis elegans)

PSME3 [nucleoplasm] (Canis familiaris)

PSME3 [nucleoplasm] (Sus scrofa)

psme3 [nucleoplasm] (Danio rerio)

psme3 [nucleoplasm] (Xenopus tropicalis)

Psme3 [nucleoplasm] (Mus musculus)

Psme3 [nucleoplasm] (Rattus norvegicus)

psmE3 [nucleoplasm] (Dictyostelium discoideum)

REG [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_005780.2, NP_789839.1

OpenTargets

ENSG00000131467

HPA

ENSG00000131467-PSME3

GeneCards

P61289

Ensembl

ENST00000590720, ENSG00000131467, ENST00000441946, ENSP00000466794, ENSP00000409487, ENST00000293362, ENSP00000293362

PRO

P61289

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.841	9
UniProt:Q9BXC9 BBS2	1	BBS2 [cytosol] (R-HSA-5617637)	0.781	7
UniProt:Q96CJ1 EAF2	1	EAF2 [nucleoplasm] (R-HSA-8932790)	0.621	3
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.612	8
UniProt:Q9Y6Q9 NCOA3	2	p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005) NCOA3 [nucleoplasm] (R-HSA-442488)	0.602	5
UniProt:Q9HCE7 SMURF1	2	SMURF1 [cytosol] (R-HSA-975972) SMURF1 [nucleoplasm] (R-HSA-3004548)	0.593	5
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.576	7
UniProt:P42677 RPS27	2	RPS27 [cytosol] (R-HSA-72361) RPS27 [nucleoplasm] (R-HSA-6791190)	0.556	3
UniProt:P30305 CDC25B	3	CDC25B [cytosol] (R-HSA-157412) p-S50,T69,S160,S321,S470-CDC25B [cytosol] (R-HSA-8863644) CDC25B [nucleoplasm] (R-HSA-69734)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	3
UniProt:Q99757 TXN2	3	2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059) TXN2 [mitochondrial matrix] (R-HSA-3323048) HC-TXN2 [mitochondrial matrix] (R-HSA-9035482)	0.556	3
UniProt:P0DTC9 N	10	phospho-SUMO1-K62-ADPr-p-S177-Ncap [cytosol] (R-COV-9694558) phospho-SUMO1-K62-ADPr-p-S177-Ncap [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694424) phospho-ADPr-p-S177-Ncap [cytosol] (R-COV-9694254) phospho-p-S177-Ncap [cytosol] (R-COV-9694472) Ncap [cytosol] (R-COV-9694300) Ncap [plasma membrane] (R-COV-9694356) phospho-SUMO1-K62-ADPr-p-S177-Ncap [nucleolus] (R-COV-9694318) phospho-SUMO1-K62-ADPr-p-S177-Ncap [plasma membrane] (R-COV-9694764) N [cytosol] (R-COV-9694314) phospho-p-S177,S181,S185,S187,S189,S191,S195,T199,S203,S207-N [cytosol] (R-COV-9694431)	0.544	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4

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