Reactome | PSMC5 [nucleoplasm]

PSMC5 [nucleoplasm]

Stable Identifier

R-HSA-174312

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Probable 26S protease regulatory subunit 8

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMC5 [nucleoplasm] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Homo sapiens)
        
        USP37:RUVLB1:PSMC5:CCNA1,CCNA2 [nucleoplasm] (Homo sapiens)
        
        USP37:RUVLB1:PSMC5 [nucleoplasm] (Homo sapiens)
        
        PSMC5 [nucleoplasm] (Homo sapiens)
        
        USP37:RUVLB1:PSMC5:PolyUb-CCNA1,PolyUb-CCNA2 [nucleoplasm] (Homo sapiens)
        
        USP37:RUVLB1:PSMC5 [nucleoplasm] (Homo sapiens)
        
        PSMC5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62195 PSMC5

Gene Names

PSMC5, SUG1

Chain

initiator methionine:1, chain:2-406

Reference Genes

BioGPS Gene:5705 PSMC5

COSMIC (genes):PSMC5 PSMC5

CTD Gene:5705 PSMC5

dbSNP Gene:5705 PSMC5

ENSEMBL:ENSG00000087191 PSMC5

ENSEMBL:ENSG00000087191.14 PSMC5

HGNC:9552 PSMC5

KEGG Gene (Homo sapiens):5705 PSMC5

Monarch:5705 PSMC5

NCBI Gene:5705 PSMC5

OMIM:601681 PSMC5

UCSC:P62195 PSMC5

Reference Transcript

Other Identifiers

11756554_x_at

16837029

209503_PM_s_at

209503_s_at

3730942

3730943

3730944

3730945

3730946

3730947

3730948

3730953

3730955

3730957

3730959

3730960

3730962

3730964

3730965

3730967

3730968

3730970

3730971

3730972

37766_s_at

5705

8009227

A_23_P164035

GE54277

GO:0000166

GO:0000502

GO:0003824

GO:0005102

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005838

GO:0006351

GO:0006355

GO:0006357

GO:0008134

GO:0008540

GO:0012501

GO:0016020

GO:0016787

GO:0016887

GO:0022624

GO:0030163

GO:0031410

GO:0031531

GO:0036402

GO:0043069

GO:0043161

GO:0043226

GO:0045892

GO:0045893

GO:0070062

GO:0072562

GO:0140296

GO:0140297

GO:0140657

GO:1901800

HMNXSV003036198

ILMN_1780189

L38810_at

PH_hs_0004597

TC17000772.hg

g2661070_3p_a_at

Participates

as a component of

Other forms of this molecule

PSMC5 [cytosol]

Inferred To

wu:fa14g03 [nucleoplasm] (Danio rerio)

Homologues of PSMC5 [nucleoplasm] (Sus scrofa)

PSMC5 [nucleoplasm] (Bos taurus)

PSMC5 [nucleoplasm] (Caenorhabditis elegans)

PSMC5 [nucleoplasm] (Canis familiaris)

PSMC5 [nucleoplasm] (Dictyostelium discoideum)

PSMC5 [nucleoplasm] (Drosophila melanogaster)

PSMC5 [nucleoplasm] (Gallus gallus)

PSMC5 [nucleoplasm] (Mus musculus)

PSMC5 [nucleoplasm] (Rattus norvegicus)

PSMC5 [nucleoplasm] (Saccharomyces cerevisiae)

PSMC5 [nucleoplasm] (Schizosaccharomyces pombe)

PSMC5 [nucleoplasm] (Sus scrofa)

psmc5 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_002796.4, NP_001186092.1

OpenTargets

ENSG00000087191

HPA

ENSG00000087191-PSMC5

GeneCards

P62195

Ensembl

ENSP00000364970, ENST00000375812, ENSG00000087191, ENSP00000462495, ENST00000310144, ENST00000580864, ENSP00000463938, ENST00000581882, ENSP00000310572

PRO

P62195

Pharos - Targets

P62195

PDB

7W3C, 5VFR, 5VHP, 5VHF, 7W3K, 5VFU, 5VHN, 7W3B, 6MSB, 7W39, 7QYA, 7W3I, 6MSK, 7QYB, 6WJN, 5VHM, 5LN3, 2KRK, 5T0I, 5VFP, 7W3G, 6MSH, 6WJD, 5VHS, 5GJR, 7QXP, 6MSD, 5L4G, 5VFQ, 5T0J, 7W3F, 7W37, 5VHQ, 6MSG, 5VFT, 7W3A, 5VGZ, 5VFS, 5VHO, 7QXN, 7W3M, 6MSJ, 5T0G, 5VHJ, 3KW6, 5T0C, 5M32, 7W3J, 8CVT, 5VHR, 5VHH, 7QXW, 5T0H, 5VHI, 7W38, 5GJQ, 7W3H

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13371 PDCL	2	PDCL [cytosol] (R-HSA-6813727) p-S18,S19,S20,S25-PDCL [cytosol] (R-HSA-6814228)	0.919	16
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.905	14
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.688	3
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [nucleoplasm] (R-HSA-5689584) UCHL5 [cytosol] (R-HSA-1629778)	0.669	5
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.643	4
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:P35398 RORA	3	RORA [nucleoplasm] (R-HSA-400325) monoSUMO1-K240-RORA [nucleoplasm] (R-HSA-4719422) polySUMO2-K240-RORA [nucleoplasm] (R-HSA-4719425)	0.553	2
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.527	2