Reactome | PSMA6 [nucleoplasm]

PSMA6 [nucleoplasm]

Stable Identifier

R-HSA-174314

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proteasome subunit alpha type 6 , Proteasome iota chain, Macropain iota chain, Multicatalytic endopeptidase complex iota chain, 27 kDa prosomal protein, PROS-27, p27K

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA6 [nucleoplasm] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA6 [nucleoplasm] (Homo sapiens)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
        
        Degradation of multiubiquitinated Cdh1 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA6 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA6 [nucleoplasm] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA6 [nucleoplasm] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Gastrulation (Homo sapiens)
  - Formation of paraxial mesoderm (Homo sapiens)
    - Somitogenesis (Homo sapiens)
      - RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA6 [nucleoplasm] (Homo sapiens)
        
        TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA6 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - Regulation of RUNX2 expression and activity (Homo sapiens)
        
        26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA6 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX3 (Homo sapiens)
      - Regulation of RUNX3 expression and activity (Homo sapiens)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA6 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Hedgehog (Homo sapiens)
  - Hedgehog 'on' state (Homo sapiens)
    - GLI2,3 are degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA6 [nucleoplasm] (Homo sapiens)
- Signaling by NOTCH (Homo sapiens)
  - Signaling by NOTCH4 (Homo sapiens)
    - Negative regulation of NOTCH4 signaling (Homo sapiens)
      - Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P60900 PSMA6

Gene Names

PSMA6, PROS27

Chain

chain:1-246

Reference Genes

BioGPS Gene:5687 PSMA6

COSMIC (genes):PSMA6 PSMA6

CTD Gene:5687 PSMA6

dbSNP Gene:5687 PSMA6

ENSEMBL:ENSG00000100902 PSMA6

HGNC:9535 PSMA6

KEGG:hsa:5687 PSMA6

Monarch:5687 PSMA6

NCBI Gene:5687 PSMA6

OMIM:602855 PSMA6

UCSC:P60900 PSMA6

Reference Transcript

Other Identifiers

11757295_x_at

208805_3p_at

208805_PM_at

208805_at

3085572

3532457

3532459

3532460

3532461

3532462

3532465

3532466

3532467

3532468

3532469

3532470

3532471

3532472

3532473

3532474

3532475

3532476

3532477

3532478

3532479

3532480

3532481

3532482

3532483

3532484

36122_at

4030209

4030210

4030212

4030213

5687

71040_at

7973936

A_14_P113003

A_23_P25735

A_24_P922120

GE596642

GE59844

GO:0000502

GO:0000932

GO:0003723

GO:0003824

GO:0004175

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0005840

GO:0006355

GO:0006511

GO:0010498

GO:0016363

GO:0016787

GO:0019773

GO:0030016

GO:0030017

GO:0030163

GO:0035639

GO:0043161

GO:0043226

GO:0050727

GO:0051059

GO:0051092

GO:0051603

GO:0070062

GO:0140096

HMNXSV003043053

ILMN_1704094

ILMN_2151818

TC14002294.hg

X59417_at

g12804240_3p_at

g12804240_3p_s_at

Participates

as a component of

20S CP outer ring [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMA6 [cytosol]

Inferred To

pas-1 [nucleoplasm] (Caenorhabditis elegans)

Homologues of PSMA6 [nucleoplasm] (Canis familiaris)

PSMA6 [nucleoplasm] (Bos taurus)

PSMA6 [nucleoplasm] (Canis familiaris)

PSMA6 [nucleoplasm] (Gallus gallus)

PSMA6 [nucleoplasm] (Sus scrofa)

psma6 [nucleoplasm] (Xenopus tropicalis)

LOC100686569 [nucleoplasm] (Canis familiaris)

Prosalpha1 [nucleoplasm] (Drosophila melanogaster)

psmA6 [nucleoplasm] (Dictyostelium discoideum)

psma6b [nucleoplasm] (Danio rerio)

Psma6 [nucleoplasm] (Mus musculus)

Psma6 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_016876957.1, NP_002782.1, NP_001269162.1, NP_001269161.1, NP_001269163.1

OpenTargets

ENSG00000100902

ENSEMBL

ENST00000261479, ENSP00000479620, ENSP00000444844, ENSP00000261479, ENST00000622405, ENSP00000452566, ENST00000555764, ENST00000540871

HPA

ENSG00000100902-PSMA6

PRO

P60900

Pharos - Targets

P60900

GlyGen

P60900

PDB

5T0H, 5T0C, 5T0I, 7PG9, 8CVR, 5L4G, 7QYA, 7V5G, 7W3M, 7W3K, 7QXN, 7W3F, 5GJQ, 5LN3, 7W38, 5LF1, 6MSB, 8QYO, 7W3H, 8QYL, 6KWY, 7V5M, 7W39, 5VFS, 7NAN, 5VFR, 6WJN, 7B12, 5VFU, 6MSH, 7W3A, 7W3I, 5VFO, 7QXW, 6AVO, 6E5B, 8CXB, 7LXV, 5LEY, 5LEZ, 4R67, 5LF3, 4R3O, 5M32, 5T0G, 5LE5, 5T0J, 6REY, 8CVT, 8CVS, 8BZL, 7QYB, 8QYS, 6MSD, 8QZ9, 7W3C, 7QXX, 7QXP, 7QY7, 5LF0, 6WJD, 8QYM, 6MSK, 7NAO, 7W3B, 7NAQ, 7W37, 7W3G, 7NAP, 5VFT, 7W3J, 8QYN, 6RGQ, 5VFQ, 6XMJ, 7QXU, 5A0Q, 8UD9, 5VFP, 6MSG, 5GJR, 7NHT, 8QYJ, 6R70, 7AWE, 5LEX, 5LF6, 5LF7, 5LF4

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.89	12
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.85	13
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285)	0.845	10
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.844	10
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.788	6
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.744	5
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143)	0.725	5
UniProt:P25789 PSMA4	2	PSMA4 [cytosol] (R-HSA-68730) PSMA4 [nucleoplasm] (R-HSA-174324)	0.669	5
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408)	0.666	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	4
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129)	0.643	4
UniProt:P28066 PSMA5	5	PSMA5 [cytosol] (R-HSA-68732) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [secretory granule lumen] (R-HSA-6803316) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328)	0.643	6
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.643	5
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.643	5
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.643	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	16
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440)	0.564	2
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413)	0.564	2
UniProt:Q0VDD7 BRME1			0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q969J2 ZKSCAN4	1	ZKSCAN4 [nucleoplasm] (R-HSA-1027423)	0.556	3
UniProt:P84090 ERH			0.556	3
UniProt:Q8TC21 ZNF596	1	ZNF596 [nucleoplasm] (R-HSA-2127570)	0.556	3
UniProt:Q8N9M1-2 C19ORF47			0.556	3
UniProt:A2RU48 SMCO3			0.556	3
UniProt:Q9BY67 CADM1	1	CADM1 [plasma membrane] (R-HSA-420589)	0.556	3
UniProt:Q96N21 AP4AT			0.556	3
UniProt:Q8NCP5 ZBT44			0.556	3
UniProt:Q14D33 RTP5			0.556	3
UniProt:P62875 POLR2L	2	POLR2L [cytosol] (R-HSA-1964467) POLR2L [nucleoplasm] (R-HSA-83715)	0.556	3
UniProt:Q9HCM9-2 TRIM39			0.556	5
UniProt:Q9BYR5 KRTAP4-2	1	KRTAP4-2 [cytosol] (R-HSA-6809948)	0.556	3
UniProt:Q9BT23 LIMD2			0.556	3
UniProt:Q6FI91 Q6FI91			0.556	3
UniProt:Q9HCM9 TRIM39	1	TRIM39 [cytosol] (R-HSA-5688971)	0.556	3
UniProt:Q96K19 RN170			0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q9Y244 POMP	1	POMP [cytosol] (R-HSA-9908067)	0.527	4
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.495	2
IntAct:EBI-4399559 UBIQ			0.462	2

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